{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:56:04Z","timestamp":1791572164341,"version":"4.3.4"},"reference-count":65,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82402710"],"award-info":[{"award-number":["82402710"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81925026"],"award-info":[{"award-number":["81925026"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82130068"],"award-info":[{"award-number":["82130068"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572635"],"award-info":[{"award-number":["82572635"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Chronic psychological stress is increasingly implicated in female reproductive disorders, yet the mechanistic link between stress and ovarian dysfunction remains incompletely understood. Using a chronic restraint stress (CRS) mouse model, we demonstrated that CRS induced anxiety-like behaviors and ovarian dysfunction, evidenced by elevated serum FSH levels, reduced estradiol (E2) and anti-M\u00fcllerian hormone levels, and impaired folliculogenesis. These phenotypes were accompanied by pronounced gut microbiota dysbiosis and disturbed metabolic profiles. Moreover, transplantation of stress-altered microbiota further exacerbated ovarian impairment in recipient mice. Stress-related gut microbiota alterations were associated with changes in ovarian clock gene expression and steroidogenic pathways. Notably, preventive oral supplementation with Lactobacillus johnsonii modulated gut microbial composition, mitigated stress-related behavioral and endocrine abnormalities, and attenuated CRS-induced alterations in ovarian clock protein expression, improved estrogen biosynthesis and follicular development. In conclusion, these findings support a proposed regulatory framework involving stress-associated gut microbiota alterations, ovarian clock gene expression, and steroidogenic dysfunction, and suggest L. johnsonii as a potential preventive microbiota-based intervention for stress-associated ovarian dysfunction.<\/jats:p>","DOI":"10.1093\/molehr\/gaag058","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:24:56Z","timestamp":1790335496000},"source":"Crossref","is-referenced-by-count":0,"title":["<i>Lactobacillus johnsonii<\/i>\n                    attenuates chronic stress-induced ovarian dysfunction by modulating ovarian clock-related steroidogenic signaling"],"prefix":"10.1093","volume":"32","author":[{"given":"Jiarui","family":"Liang","sequence":"first","affiliation":[{"name":"Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University , Guangzhou, Guangdong,","place":["China"]},{"name":"Department of Laboratory Medicine, Shenzhen Hospital, Southern Medical University , Shenzhen, Guangdong,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Chen","sequence":"additional","affiliation":[{"name":"Obstetrics and Gynecology Medical Center, Zhujiang Hospital, Southern Medical University , Guangzhou, Guangdong,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshui","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Science and Technology Innovation, Shenzhen Hospital, Southern Medical University , Shenzhen, Guangdong,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziwei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University , Guangzhou, Guangdong,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shulei","family":"Chen","sequence":"additional","affiliation":[{"name":"Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University , Guangzhou, Guangdong,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuyu","family":"Li","sequence":"additional","affiliation":[{"name":"Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University , Guangzhou, Guangdong,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Yan","sequence":"additional","affiliation":[{"name":"Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University , Guangzhou, Guangdong,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4501-5508","authenticated-orcid":false,"given":"Dongxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University , Guangzhou, Guangdong,","place":["China"]},{"name":"Guangdong Provincial Clinical Research Center for Laboratory Medicine , Guangzhou, Guangdong,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2472-8541","authenticated-orcid":false,"given":"Hongwei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University , Guangzhou, Guangdong,","place":["China"]},{"name":"Department of Science and Technology Innovation, Shenzhen Hospital, Southern Medical University , Shenzhen, Guangdong,","place":["China"]},{"name":"State Key Laboratory of Multi-Organ Injury Prevention and Treatment, Southern Medical University , Guangzhou, Guangdong,","place":["China"]},{"name":"Shenzhen Key Laboratory of Gastrointestinal Microbiota and Disease, Department of Gastroenterology, Gynecology and Obstetrics, and Laboratory Medicine, Shenzhen Hospital, Southern Medical University , Shenzhen, Guangdong,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6507-0497","authenticated-orcid":false,"given":"Bingyu","family":"Li","sequence":"additional","affiliation":[{"name":"Microbiome Medicine Center, Department of Laboratory Medicine, Zhujiang Hospital, Southern Medical University , Guangzhou, Guangdong,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"2026100914470372200_gaag058-B1","doi-asserted-by":"crossref","first-page":"e12590","DOI":"10.1111\/jne.12590","article-title":"Emerging insights into hypothalamic-pituitary-gonadal (HPG) axis regulation and interaction with stress signaling","volume":"30","author":"Acevedo-Rodriguez","year":"2018","journal-title":"J Neuroendocrinol"},{"key":"2026100914470372200_gaag058-B2","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1038\/nmeth.3176","article-title":"Fast and sensitive protein alignment using DIAMOND","volume":"12","author":"Buchfink","year":"2015","journal-title":"Nat Methods"},{"key":"2026100914470372200_gaag058-B3","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: high resolution sample inference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat Methods"},{"key":"2026100914470372200_gaag058-B4","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1158\/0008-5472.CAN-22-3705","article-title":"Chronic stress dampens Lactobacillus johnsonii-mediated tumor suppression to enhance colorectal cancer progression","volume":"84","author":"Cao","year":"2024","journal-title":"Cancer Res"},{"key":"2026100914470372200_gaag058-B5","doi-asserted-by":"crossref","first-page":"4654","DOI":"10.1158\/0008-5472.CAN-22-0455","article-title":"Disruption of the gut microbiota confers cisplatin resistance in epithelial ovarian cancer","volume":"82","author":"Chambers","year":"2022","journal-title":"Cancer Res"},{"key":"2026100914470372200_gaag058-B6","doi-asserted-by":"crossref","first-page":"5393","DOI":"10.1016\/j.cell.2024.07.019","article-title":"Stress-sensitive neural circuits change the gut microbiome via duodenal glands","volume":"187","author":"Chang","year":"2024","journal-title":"Cell"},{"key":"2026100914470372200_gaag058-B7","doi-asserted-by":"crossref","first-page":"C1131","DOI":"10.1152\/ajpcell.00008.2013","article-title":"Downregulation of core clock gene Bmal1 attenuates expression of progesterone and prostaglandin biosynthesis-related genes in rat luteinizing granulosa cells","volume":"304","author":"Chen","year":"2013","journal-title":"Am J Physiol Cell Physiol"},{"key":"2026100914470372200_gaag058-B8","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"key":"2026100914470372200_gaag058-B9","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/s41575-021-00452-2","article-title":"Gut microbiota as a transducer of dietary cues to regulate host circadian rhythms and metabolism","volume":"18","author":"Choi","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"2026100914470372200_gaag058-B10","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.1093\/bioinformatics\/bty528","article-title":"MetaboAnalystR: an R package for flexible and reproducible analysis of metabolomics data","volume":"34","author":"Chong","year":"2018","journal-title":"Bioinformatics"},{"key":"2026100914470372200_gaag058-B11","doi-asserted-by":"crossref","first-page":"2295429","DOI":"10.1080\/19490976.2023.2295429","article-title":"Gut microbiome responds to alteration in female sex hormone status and exacerbates metabolic dysfunction","volume":"16","author":"Cross","year":"2024","journal-title":"Gut Microbes"},{"key":"2026100914470372200_gaag058-B12","doi-asserted-by":"crossref","first-page":"101678","DOI":"10.1016\/j.xcrm.2024.101678","article-title":"\u03b2-resorcylic acid released by Limosilactobacillus reuteri protects against cisplatin-induced ovarian toxicity and infertility","volume":"5","author":"Feng","year":"2024","journal-title":"Cell Rep Med"},{"key":"2026100914470372200_gaag058-B13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/2049-2618-2-15","article-title":"Unifying the analysis of high-throughput sequencing datasets: characterizing RNA-seq, 16S rRNA gene sequencing and selective growth experiments by compositional data analysis","volume":"2","author":"Fernandes","year":"2014","journal-title":"Microbiome"},{"key":"2026100914470372200_gaag058-B14","doi-asserted-by":"crossref","first-page":"e2412558","DOI":"10.1002\/advs.202412558","article-title":"Gut microbiota modulation by inulin improves metabolism and ovarian function in polycystic ovary syndrome","volume":"12","author":"Geng","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"2026100914470372200_gaag058-B15","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1210\/endrev\/bnaf011","article-title":"Epidemiology, genetic etiology, and intervention of premature ovarian insufficiency","volume":"46","author":"Guo","year":"2025","journal-title":"Endocr Rev"},{"key":"2026100914470372200_gaag058-B33","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.cmet.2021.03.015","article-title":"Circadian rhythms and the gut microbiome synchronize the host's metabolic response to diet","volume":"33","author":"Gutierrez Lopez","year":"2021","journal-title":"Cell Metab"},{"key":"2026100914470372200_gaag058-B16","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1152\/physrev.00023.2015","article-title":"Physiological aspects of female fertility: role of the environment, modern lifestyle, and genetics","volume":"96","author":"Hart","year":"2016","journal-title":"Physiol Rev"},{"key":"2026100914470372200_gaag058-B17","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.ccell.2024.01.013","article-title":"Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment","volume":"42","author":"He","year":"2024","journal-title":"Cancer Cell"},{"key":"2026100914470372200_gaag058-B18","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3892\/ijmm.2024.5475","article-title":"Impact of psychological stress on ovarian function: insights, mechanisms and intervention strategies (review)","volume":"55","author":"Hu","year":"2025","journal-title":"Int J Mol Med"},{"key":"2026100914470372200_gaag058-B19","doi-asserted-by":"crossref","first-page":"2295394","DOI":"10.1080\/19490976.2023.2295394","article-title":"The influence of the gut microbiome on ovarian aging","volume":"16","author":"Huang","year":"2024","journal-title":"Gut Microbes"},{"key":"2026100914470372200_gaag058-B20","doi-asserted-by":"crossref","first-page":"e1004957","DOI":"10.1371\/journal.pcbi.1004957","article-title":"MEGAN community edition \u2013 interactive exploration and analysis of large-scale microbiome sequencing data","volume":"12","author":"Huson","year":"2016","journal-title":"PLoS Comput Biol"},{"key":"2026100914470372200_gaag058-B21","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/1471-2105-11-119","article-title":"Prodigal: prokaryotic gene recognition and translation initiation site identification","volume":"11","author":"Hyatt","year":"2010","journal-title":"BMC Bioinformatics"},{"key":"2026100914470372200_gaag058-B22","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/humupd\/dmae027","article-title":"New insights into the ovulatory process in the human ovary","volume":"31","author":"Jo","year":"2025","journal-title":"Hum Reprod Update"},{"key":"2026100914470372200_gaag058-B23","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: Kyoto Encyclopedia of Genes and Genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res"},{"key":"2026100914470372200_gaag058-B24","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/s41587-019-0201-4","article-title":"Graph-based genome alignment and genotyping with HISAT2 and HISAT-genotype","volume":"37","author":"Kim","year":"2019","journal-title":"Nat Biotechnol"},{"key":"2026100914470372200_gaag058-B25","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/s43587-026-01069-3","article-title":"Estropausal gut microbiota transplant improves measures of ovarian function in adult mice","volume":"6","author":"Kim","year":"2026","journal-title":"Nat Aging"},{"key":"2026100914470372200_gaag058-B26","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/nmeth.1923","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","journal-title":"Nat Methods"},{"key":"2026100914470372200_gaag058-B27","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1186\/1471-2105-12-323","article-title":"RSEM: accurate transcript quantification from RNA-seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","journal-title":"BMC Bioinformatics"},{"key":"2026100914470372200_gaag058-B28","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1093\/bioinformatics\/btp324","article-title":"Fast and accurate short read alignment with Burrows\u2013Wheeler transform","volume":"25","author":"Li","year":"2009","journal-title":"Bioinformatics"},{"key":"2026100914470372200_gaag058-B29","doi-asserted-by":"crossref","first-page":"4600","DOI":"10.1158\/0008-5472.CAN-25-0879","article-title":"Lactobacillus johnsonii synthesizes chenodeoxycholic acid to reduce susceptibility to high-fat diet-induced colorectal cancer","volume":"85","author":"Liu","year":"2025","journal-title":"Cancer Res"},{"key":"2026100914470372200_gaag058-B30","doi-asserted-by":"crossref","first-page":"e1236","DOI":"10.1002\/ctm2.1236","article-title":"Gut microbiota\u2013bile acid-vitamin D axis plays an important role in determining oocyte quality and embryonic development","volume":"13","author":"Li","year":"2023","journal-title":"Clin Transl Med"},{"key":"2026100914470372200_gaag058-B31","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1093\/bioinformatics\/btv033","article-title":"MEGAHIT: an ultra-fast single-node solution for large and complex metagenomics assembly via succinct de Bruijn graph","volume":"31","author":"Li","year":"2015","journal-title":"Bioinformatics"},{"key":"2026100914470372200_gaag058-B32","doi-asserted-by":"crossref","first-page":"14295","DOI":"10.1073\/pnas.1209249111","article-title":"Loss of BMAL1 in ovarian steroidogenic cells results in implantation failure in female mice","volume":"111","author":"Liu","year":"2014","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026100914470372200_gaag058-B34","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"2026100914470372200_gaag058-B35","doi-asserted-by":"crossref","first-page":"e70082","DOI":"10.1111\/aji.70082","article-title":"Moxibustion enhances ovarian function by inhibiting the Th17\/IL-17 pathway and regulating gut microbiota in POI rats","volume":"93","author":"Luo","year":"2025","journal-title":"Am J Reprod Immunol"},{"key":"2026100914470372200_gaag058-B36","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1007\/s11011-024-01393-w","article-title":"Stress, hypothalamic-pituitary-adrenal axis, hypothalamic-pituitary-gonadal axis, and aggression","volume":"39","author":"Mbiydzenyuy","year":"2024","journal-title":"Metab Brain Dis"},{"key":"2026100914470372200_gaag058-B37","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41392-024-01913-1","article-title":"Targeting Lactobacillus johnsonii to reverse chronic kidney disease","volume":"9","author":"Miao","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"2026100914470372200_gaag058-B38","doi-asserted-by":"crossref","first-page":"e077469","DOI":"10.1136\/bmj-2023-077469","article-title":"Premature ovarian insufficiency","volume":"384","author":"Nash","year":"2024","journal-title":"BMJ"},{"key":"2026100914470372200_gaag058-B39","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1038\/nbt.3122","article-title":"StringTie enables improved reconstruction of a transcriptome from RNA-seq reads","volume":"33","author":"Pertea","year":"2015","journal-title":"Nat Biotechnol"},{"key":"2026100914470372200_gaag058-B40","doi-asserted-by":"crossref","first-page":"100928","DOI":"10.1016\/j.yfrne.2021.100928","article-title":"Neuroendocrine interactions of the stress and reproductive axes","volume":"63","author":"Phumsatitpong","year":"2021","journal-title":"Front Neuroendocrinol"},{"key":"2026100914470372200_gaag058-B41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19490976.2021.1894070","article-title":"The impact of the gut microbiota on the reproductive and metabolic endocrine system","volume":"13","author":"Qi","year":"2021","journal-title":"Gut Microbes"},{"key":"2026100914470372200_gaag058-B42","doi-asserted-by":"crossref","first-page":"101798","DOI":"10.1016\/j.xcrm.2024.101798","article-title":"Bifidobacteria with indole-3-lactic acid-producing capacity exhibit psychobiotic potential via reducing neuroinflammation","volume":"5","author":"Qian","year":"2024","journal-title":"Cell Rep Med"},{"key":"2026100914470372200_gaag058-B43","doi-asserted-by":"crossref","first-page":"D590","DOI":"10.1093\/nar\/gks1219","article-title":"The SILVA ribosomal RNA gene database project: improved data processing and web-based tools","volume":"41","author":"Quast","year":"2013","journal-title":"Nucleic Acids Res"},{"key":"2026100914470372200_gaag058-B44","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1210\/er.2018-00280","article-title":"The gut microbiome influences host endocrine functions","volume":"40","author":"Rastelli","year":"2019","journal-title":"Endocr Rev"},{"key":"2026100914470372200_gaag058-B45","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.tins.2016.09.002","article-title":"Psychobiotics and the manipulation of bacteria\u2013gut\u2013brain signals","volume":"39","author":"Sarkar","year":"2016","journal-title":"Trends Neurosci"},{"key":"2026100914470372200_gaag058-B46","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1097\/EDE.0000000000000238","article-title":"Perceived stress, reproductive hormones, and ovulatory function: a prospective cohort study","volume":"26","author":"Schliep","year":"2015","journal-title":"Epidemiology"},{"key":"2026100914470372200_gaag058-B47","doi-asserted-by":"crossref","first-page":"R60","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"Segata","year":"2011","journal-title":"Genome Biol"},{"key":"2026100914470372200_gaag058-B48","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.tem.2010.06.002","article-title":"Circadian clocks in the ovary","volume":"21","author":"Sellix","year":"2010","journal-title":"Trends Endocrinol Metab"},{"key":"2026100914470372200_gaag058-B49","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1038\/nbt.3988","article-title":"MMseqs2 enables sensitive protein sequence searching for the analysis of massive data sets","volume":"35","author":"Steinegger","year":"2017","journal-title":"Nat Biotechnol"},{"key":"2026100914470372200_gaag058-B50","doi-asserted-by":"crossref","first-page":"856044","DOI":"10.3389\/fendo.2022.856044","article-title":"Chronic and cumulative adverse life events in women with primary ovarian insufficiency: an exploratory qualitative study","volume":"13","author":"Sun","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2026100914470372200_gaag058-B51","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.jare.2025.06.035","article-title":"Lactobacillus johnsonii-derived extracellular vesicles carrying GAPDH protect against ulcerative colitis through modulating macrophage polarization","volume":"81","author":"Tao","year":"2026","journal-title":"J Adv Res"},{"key":"2026100914470372200_gaag058-B52","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.cmet.2024.10.003","article-title":"Gut microbiota regulates stress responsivity via the circadian system","volume":"37","author":"Tofani","year":"2025","journal-title":"Cell Metab"},{"key":"2026100914470372200_gaag058-B53","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1016\/j.jgg.2026.03.023","article-title":"Probiotic potential of Parabacteroides johnsonii in mitigating age-related ovarian functional decline","volume":"53","author":"Wang","year":"2026","journal-title":"J Genet Genomics"},{"key":"2026100914470372200_gaag058-B54","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.cmet.2023.12.026","article-title":"Psychological stress-induced microbial metabolite indole-3-acetate disrupts intestinal cell lineage commitment","volume":"36","author":"Wei","year":"2024","journal-title":"Cell Metab"},{"key":"2026100914470372200_gaag058-B55","first-page":"132","article-title":"Difference of the gut microbiota of premature ovarian insufficiency in two traditional Chinese syndromes","volume":"45","author":"Wu","year":"2025","journal-title":"J Tradit Chin Med"},{"key":"2026100914470372200_gaag058-B56","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1186\/s12884-021-03855-w","article-title":"Association between premature ovarian insufficiency and gut microbiota","volume":"21","author":"Wu","year":"2021","journal-title":"BMC Pregnancy Childbirth"},{"key":"2026100914470372200_gaag058-B57","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1186\/s40168-025-02174-y","article-title":"Gut microbiota-derived short-chain fatty acids promote follicular maturation via gWAT-ovary axis in mammals","volume":"13","author":"Xu","year":"2025","journal-title":"Microbiome"},{"key":"2026100914470372200_gaag058-B58","doi-asserted-by":"crossref","first-page":"3760","DOI":"10.7150\/thno.95197","article-title":"Sleep deprivation causes gut dysbiosis impacting on systemic metabolomics leading to premature ovarian insufficiency in adolescent mice","volume":"14","author":"Yan","year":"2024","journal-title":"Theranostics"},{"key":"2026100914470372200_gaag058-B59","doi-asserted-by":"crossref","first-page":"127292","DOI":"10.1016\/j.micres.2022.127292","article-title":"Acute sleep deprivation exacerbates systemic inflammation and psychiatry disorders through gut microbiota dysbiosis and disruption of circadian rhythms","volume":"268","author":"Yang","year":"2023","journal-title":"Microbiol Res"},{"key":"2026100914470372200_gaag058-B60","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/s41538-026-00823-6","article-title":"Lactobacillus salivarius li01 alleviates premature ovarian insufficiency via gut microbiota-mediated modulation of tryptophan metabolism","volume":"10","author":"Yao","year":"2026","journal-title":"NPJ Sci Food"},{"key":"2026100914470372200_gaag058-B61","doi-asserted-by":"crossref","first-page":"e2405781","DOI":"10.1002\/advs.202405781","article-title":"Postbiotics from Lactobacillus johnsonii activates gut innate immunity to mitigate alcohol-associated liver disease","volume":"12","author":"Yin","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"2026100914470372200_gaag058-B62","doi-asserted-by":"crossref","first-page":"skae185","DOI":"10.1093\/jas\/skae185","article-title":"Period circadian regulator 2-mediated steroid hormone synthesis by regulating transcription of steroidogenic acute regulatory protein in porcine granulosa cells","volume":"102","author":"Zhang","year":"2024","journal-title":"J Anim Sci"},{"key":"2026100914470372200_gaag058-B63","doi-asserted-by":"crossref","first-page":"C231","DOI":"10.1152\/ajpcell.00267.2021","article-title":"Circadian clock regulates granulosa cell autophagy through NR1D1-mediated inhibition of ATG5","volume":"322","author":"Zhang","year":"2022","journal-title":"Am J Physiol Cell Physiol"},{"key":"2026100914470372200_gaag058-B64","doi-asserted-by":"crossref","first-page":"100416","DOI":"10.1016\/j.advnut.2025.100416","article-title":"Interactions between gut microbiota, host circadian rhythms, and metabolic diseases","volume":"16","author":"Zhang","year":"2025","journal-title":"Adv Nutr"},{"key":"2026100914470372200_gaag058-B65","doi-asserted-by":"crossref","first-page":"7209","DOI":"10.1039\/D3FO01659E","article-title":"Integrated gut microbiota and fecal metabolome analyses of the effect of Lycium barbarum polysaccharide on D-galactose-induced premature ovarian insufficiency","volume":"14","author":"Zheng","year":"2023","journal-title":"Food Funct"}],"container-title":["Molecular Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/molehr\/advance-article-pdf\/doi\/10.1093\/molehr\/gaag058\/71400376\/gaag058.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/molehr\/article-pdf\/32\/4\/gaag058\/71400376\/gaag058.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/molehr\/article-pdf\/32\/4\/gaag058\/71400376\/gaag058.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:47:14Z","timestamp":1791571634000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/molehr\/article\/doi\/10.1093\/molehr\/gaag058\/8836415"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,10,6]]}},"URL":"https:\/\/doi.org\/10.1093\/molehr\/gaag058","relation":{},"ISSN":["1360-9947","1460-2407"],"issn-type":[{"value":"1360-9947","type":"print"},{"value":"1460-2407","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026]]},"published":{"date-parts":[[2026]]},"article-number":"gaag058"}}