{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:36:41Z","timestamp":1789951001733,"version":"4.0.1"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1093\/molehr\/gaq102","type":"journal-article","created":{"date-parts":[[2010,12,22]],"date-time":"2010-12-22T20:18:55Z","timestamp":1293049135000},"page":"360-371","source":"Crossref","is-referenced-by-count":30,"title":["Expression of milk fat globule EGF-factor 8 (MFG-E8) mRNA and protein in the human endometrium and its regulation by prolactin"],"prefix":"10.1093","volume":"17","author":[{"given":"Anahi","family":"Franchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvina","family":"Bocca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Riggs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Oehninger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2010,12,21]]},"reference":[{"key":"key\n\t\t\t\t20170511064149_GAQ102C1","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.yexcr.2003.09.011","article-title":"The opsonin MFG-E8 is a ligand for the alphavbeta5 integrin and triggers DOCK180-dependent Rac1 activation for the phagocytosis of apoptotic cells","volume":"292","author":"Akakura","year":"2004","journal-title":"Exp Cell Res"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C2","doi-asserted-by":"crossref","first-page":"6200","DOI":"10.1021\/bi992221r","article-title":"Functional analyses of two cellular binding domains of bovine lactadherin","volume":"39","author":"Andersen","year":"2000","journal-title":"Biochemistry"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C3","first-page":"4991","article-title":"Osteopontin and its receptor alphavbeta(3) integrin are coexpressed in the human endometrium during the menstrual cycle but regulated differentially","volume":"86","author":"Apparao","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C4","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1007\/s10495-008-0201-1","article-title":"Prolactin induces MFG-E8 production in macrophages via transcription factor C\/EBPbeta-dependent pathway","volume":"13","author":"Aziz","year":"2008","journal-title":"Apoptosis"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C5","doi-asserted-by":"crossref","first-page":"7222","DOI":"10.4049\/jimmunol.0803711","article-title":"MFG-E8 attenuates intestinal inflammation in murine experimental colitis by modulating osteopontin-dependent \u03b1v\u03b23 integrin signaling","volume":"182","author":"Aziz","year":"2009","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C6","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/BF02820507","article-title":"Progesterone-dependent decidualization of the human endometrium is mediated by cAMP","volume":"6","author":"Brar","year":"1997","journal-title":"Endocrine"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C7","first-page":"3673","article-title":"Milk fat globule-EGF factor 8\/lactadherin plays a crucial role in maintenance and repair of murine intestinal epithelium","volume":"117","author":"Bu","year":"2007","journal-title":"J Clin Invest"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C8","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1073\/pnas.74.2.582","article-title":"Surface differentiation antigens of human mammary epithelial cells carried on the human milk fat globule","volume":"74","author":"Ceriani","year":"1977","journal-title":"Proc Natl Acad Sci"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C9","doi-asserted-by":"crossref","first-page":"5420","DOI":"10.1073\/pnas.79.17.5420","article-title":"Circulating human mammary epithelial antigens in breast cancer","volume":"79","author":"Ceriani","year":"1982","journal-title":"Proc Natl Acad Sci"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C10","doi-asserted-by":"crossref","first-page":"2014","DOI":"10.1016\/j.fertnstert.2008.09.004","article-title":"The mouse gamete adhesin, SED1, is expressed on the surface of acrosome-intact human sperm","volume":"92","author":"Copland","year":"2008","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C11","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0092-8674(03)00643-3","article-title":"Identification of mouse sperm SED1, a bimotif EGF repeat and discoidin-domain protein involved in sperm-egg binding","volume":"114","author":"Ensslin","year":"2003","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C12","doi-asserted-by":"crossref","first-page":"2715","DOI":"10.1073\/pnas.0610296104","article-title":"The EGF repeat and discoidin domain protein, SED1\/MFG-E8, is required for mammary gland branching morphogenesis","volume":"104","author":"Ensslin","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C13","doi-asserted-by":"crossref","first-page":"4542","DOI":"10.1182\/blood-2007-06-094763","article-title":"Angiogenic endothelium shows lactadherin-dependent phagocytosis of aged erythrocytes and apoptotic cells","volume":"111","author":"Fens","year":"2008","journal-title":"Blood"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C14","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/molehr\/gan029","article-title":"Expression of immunomodulatory genes, their protein products and specific ligands\/receptors during the window of implantation in the human endometrium","volume":"14","author":"Franchi","year":"2008","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C15","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1095\/biolreprod.104.036426","article-title":"Identification, proteomic profiling, and origin of ram epididymal fluid exosome-like vesicles","volume":"72","author":"Gatti","year":"2005","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C16","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1055\/s-2007-991042","article-title":"Decidualization of the human endometrium: mechanisms, functions, and clinical perspectives","volume":"25","author":"Gellersen","year":"2007","journal-title":"Semin Reprod Med"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C17","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/0959-437X(95)80027-1","article-title":"Prolactin-mediated gene activation in mammary epithelial cells","volume":"5","author":"Groner","year":"1995","journal-title":"Curr Opin Genet Dev"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C18","doi-asserted-by":"crossref","first-page":"16886","DOI":"10.1073\/pnas.0508599102","article-title":"Impaired involution of mammary glands in the absence of milk fat globule EGF factor 8","volume":"102","author":"Hanayama","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C19","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/417182a","article-title":"Identification of a factor that links apoptotic cells to phagocytes","volume":"417","author":"Hanayama","year":"2002","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C20","doi-asserted-by":"crossref","first-page":"3876","DOI":"10.4049\/jimmunol.172.6.3876","article-title":"Expression of developmental endothelial locus-1 in a subset of macrophages for engulfment of apoptotic cells","volume":"172","author":"Hanayama","year":"2004","journal-title":"J Immunol"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C21","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1126\/science.1094359","article-title":"Autoimmune disease and impaired uptake of apoptotic cells in MFG-E8-deficient mice","volume":"304","author":"Hanayama","year":"2004","journal-title":"Science"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C22","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0344-0338(11)81159-3","article-title":"The expression of CEA, CA 19\u20139 and HMFG antigens in ovarian clear-cell and endometrioid carcinomas","volume":"188","author":"Helle","year":"1992","journal-title":"Pathol Res Pract"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C23","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1101\/gad.12.1.21","article-title":"Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor","volume":"12","author":"Hidai","year":"1998","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C24","doi-asserted-by":"crossref","first-page":"6926","DOI":"10.1093\/emboj\/16.23.6926","article-title":"Defective mammopoiesis, but normal hematopoiesis, in mice with a targeted disruption of the prolactin gene","volume":"16","author":"Horseman","year":"1997","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C25","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1749-6632.1994.tb21730.x","article-title":"Growth factors and decidualization in vitro","volume":"734","author":"Irwin","year":"1994","journal-title":"Ann N Y Acad Sci"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C26","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1530\/rep.0.1210197","article-title":"Potential roles of decidual prolactin in early pregnancy","volume":"121","author":"Jabbour","year":"2001","journal-title":"Reproduction"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C27","doi-asserted-by":"crossref","first-page":"2545","DOI":"10.1210\/jcem.83.7.4989","article-title":"Expression of functional prolactin receptors in nonpregnant human endometrium: janus kinase-2, signal transducer and activator of transcription-1 (STAT1), and STAT5 proteins are phosphorylated after stimulation with prolactin","volume":"83","author":"Jabbour","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C28","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1210\/jcem.83.1.4506","article-title":"Localization and temporal expression of prolactin receptor in human endometrium","volume":"83","author":"Jones","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C29","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1093\/humrep\/dep181","article-title":"Effects of gonadotrophin releasing hormone analogues on human endometrial stromal cells and embryo invasion in vitro","volume":"24","author":"Klemmt","year":"2009","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C30","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jneuroim.2004.11.012","article-title":"Fractalkine-upregulated milk-fat globule EGF factor-8 protein in cultured rat microglia","volume":"160","author":"Leonardi-Essmann","year":"2005","journal-title":"J Neuroimmunol"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C31","doi-asserted-by":"crossref","first-page":"31725","DOI":"10.1074\/jbc.M704723200","article-title":"Bone morphogenetic protein 2 functions via a conserved signaling pathway involving Wnt4 to regulate uterine decidualization in the mouse and the human","volume":"282","author":"Li","year":"2007","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C32","doi-asserted-by":"crossref","first-page":"5742","DOI":"10.1210\/jc.2004-0605","article-title":"Gene expression profiles and structural\/functional features of the peri-implantation endometrium in natural and gonadotropin-stimulated cycles","volume":"89","author":"Mirkin","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C33","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1093\/humrep\/dei051","article-title":"In search of candidate genes critically expressed in the human endometrium during the window of implantation","volume":"20","author":"Mirkin","year":"2005","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C34","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1111\/j.1471-0528.1983.tb06447.x","article-title":"Cervical wart virus infection, intraepithelial neoplasia and carcinoma; an immunohistological study using a panel of monoclonal antibodies","volume":"90","author":"Morris","year":"1983","journal-title":"Br J Obstet Gynaecol"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C35","doi-asserted-by":"crossref","first-page":"12005","DOI":"10.1073\/pnas.0704756104","article-title":"Essential role for MFG-E8 as ligand for alphavbeta5 integrin in diurnal retinal phagocytosis","volume":"104","author":"Nandrot","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C36","doi-asserted-by":"crossref","first-page":"6777","DOI":"10.1158\/0008-5472.CAN-07-0165","article-title":"MFG-E8\/lactadherin promotes tumor growth in an angiogenesis-dependent transgenic mouse model of multistage carcinogenesis","volume":"67","author":"Neutzner","year":"2007","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C37","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/S0140-6736(97)10322-1","article-title":"Role of human-milk lactadherin in protection against symptomatic rotavirus infection","volume":"351","author":"Newburg","year":"1998","journal-title":"Lancet"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C38","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0015-0282(16)30062-0","article-title":"Dating the endometrial biopsy","volume":"1","author":"Noyes","year":"1950","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C39","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.fertnstert.2007.04.026","article-title":"Revealing the enigmas of implantation: what is the true impact of ovarian hyperstimulation?","volume":"89","author":"Oehninger","year":"2008","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C40","first-page":"955","article-title":"Expression of human milk fat globule-1 in carcinomas of the uterine cervix treated with radiation therapy alone","volume":"116","author":"Oka","year":"1992","journal-title":"Arch Pathol Lab Med"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C41","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/sj.onc.1210646","article-title":"p63(TP63) elicits strong trans-activation of the MFG-E8\/lactadherin\/BA46 gene through interactions between the TA and DeltaN isoforms","volume":"27","author":"Okuyama","year":"2008","journal-title":"Oncogene"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C42","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1101\/gad.11.2.167","article-title":"Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse","volume":"11","author":"Ormandy","year":"1997","journal-title":"Genes Dev"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C43","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1006\/bbrc.1998.0107","article-title":"Lactation-dependent expression of an mRNA splice variant with an exon for a multiply O-glycosylated domain of mouse milk fat globule glycoprotein MFG-E8","volume":"254","author":"Oshima","year":"1999","journal-title":"Biochem Biophys Res Commun"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C44","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1046\/j.1432-1033.2002.02758.x","article-title":"Secretion of a peripheral membrane protein, MFG-E8, as a complex with membrane vesicles","volume":"269","author":"Oshima","year":"2002","journal-title":"Eur J Biochem"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C45","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1002\/jcb.22076","article-title":"SED1\/MFG-E8: a bi-motif protein that orchestrates diverse cellular interactions","volume":"106","author":"Raymond","year":"2009","journal-title":"J Cell Biochem"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C46","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/molehr\/gag078","article-title":"Human myometrial adaptation to pregnancy: cDNA microarray gene expression profiling of myometrium from non-pregnant and pregnant women","volume":"9","author":"Rehman","year":"2003","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C47","doi-asserted-by":"crossref","first-page":"S120","DOI":"10.1016\/j.fertnstert.2009.07.1134","article-title":"Regulation of Milk Fat Globule Epithelial Growth Factor 8 (MFG-E8) by human chorionic gonadotropin (hCG) in the human endometrium","volume":"92","author":"Riggs","year":"2009","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C48","first-page":"147","article-title":"Cytological aspects of milk formation and secretion","volume-title":"Lactation, a Comprehensive Treatise, Vol. II, Biosynthesis and Secretion of Milk\/Diseases","author":"Saacke","year":"1974"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C49","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1095\/biolreprod.108.070003","article-title":"Differences in prolactin receptor (PRLR) in mouse and human fallopian tubes: evidence for multiple regulatory mechanisms controlling PRLR isoform expression in mice","volume":"79","author":"Shao","year":"2008","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C50","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nm1233","article-title":"Lacthadherin promotes VEGF-dependent neovascularization","volume":"11","author":"Silvestre","year":"2005","journal-title":"Nat Med"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C51","first-page":"549","article-title":"Localization of interleukin-1 type I receptor and interleukin-1 beta in human endometrium throughout the menstrual cycle","volume":"77","author":"Sim\u00f3n","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C52","first-page":"675","article-title":"The effect of interleukin-1 beta (IL-1 beta) on the regulation of IL-1 receptor type I messenger ribonucleic acid and protein levels in cultured human endometrial stromal and glandular cells","volume":"78","author":"Sim\u00f3n","year":"1994","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C53","doi-asserted-by":"crossref","first-page":"8417","DOI":"10.1073\/pnas.87.21.8417","article-title":"cDNA cloning of a mouse mammary epithelial cell surface protein reveals the existence of epidermal growth factor-like domains linked to factor VIII-like sequences","volume":"87","author":"Stubbs","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C54","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1089\/dna.1997.16.861","article-title":"Lactadherin (formerly BA46), a membrane-associated glycoprotein expressed in human milk and breast carcinomas, promotes Arg-Gly-Asp (RGD)-dependent cell adhesion","volume":"16","author":"Taylor","year":"1997","journal-title":"DNA Cell Biol"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C55","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1093\/humupd\/4.5.472","article-title":"Marker genes of decidualization: activation of the decidual prolactin gene","volume":"4","author":"Telgmann","year":"1998","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C56","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1369\/jhc.2009.953729","article-title":"Bovine Lactadherin as a Calcium-independent Imaging Agent of Phosphatidylserine Expressed on the Surface of Apoptotic HeLa Cells","volume":"57","author":"Waehrens","year":"2009","journal-title":"J Histochem Cytochem"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C57","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s00441-005-1148-y","article-title":"Production of the long and short forms of MFG-E8 by epidermal keratinocytes","volume":"321","author":"Watanabe","year":"2005","journal-title":"Cell Tissue Res"},{"key":"key\n\t\t\t\t20170511064149_GAQ102C58","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1189\/jlb.1107730","article-title":"Milk fat globule EGF factor 8 in the serum of human patients of systemic lupus erythematosus","volume":"83","author":"Yamaguchi","year":"2008","journal-title":"J Leuk Biol"}],"container-title":["MHR: Basic science of reproductive medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/molehr\/article-pdf\/17\/6\/360\/12698415\/gaq102.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T15:23:07Z","timestamp":1503501787000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/molehr\/article-lookup\/doi\/10.1093\/molehr\/gaq102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,21]]},"references-count":58,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2010,12,21]]},"published-print":{"date-parts":[[2011,6]]}},"URL":"https:\/\/doi.org\/10.1093\/molehr\/gaq102","relation":{},"ISSN":["1460-2407","1360-9947"],"issn-type":[{"value":"1460-2407","type":"electronic"},{"value":"1360-9947","type":"print"}],"subject":[],"published":{"date-parts":[[2010,12,21]]}}}