{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T17:47:29Z","timestamp":1791136049457,"version":"4.1.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"10","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,10]]},"DOI":"10.1093\/molehr\/gat042","type":"journal-article","created":{"date-parts":[[2013,6,12]],"date-time":"2013-06-12T20:59:49Z","timestamp":1371070789000},"page":"665-675","source":"Crossref","is-referenced-by-count":33,"title":["Homeobox gene transforming growth factor \u03b2-induced factor-1 (TGIF-1) is a regulator of villous trophoblast differentiation and its expression is increased in human idiopathic fetal growth restriction"],"prefix":"10.1093","volume":"19","author":[{"given":"Niroshani A.","family":"Pathirage","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Cocquebert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoel","family":"Sadovsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Abumaree","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ursula","family":"Manuelpillai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Borg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosemary J.","family":"Keogh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun P.","family":"Brennecke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Evain-Brion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Fournier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bill","family":"Kalionis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Padma","family":"Murthi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,6,11]]},"reference":[{"key":"key\n\t\t\t\t20170511064723_GAT042C1","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/humrep\/dei272","article-title":"Differential effects of inducers of syncytialization and apoptosis on BeWo and JEG-3 choriocarcinoma cells","volume":"21","author":"Al-Nasiry","year":"2006","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20170511064723_GAT042C2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.ydbio.2008.04.027","article-title":"Maternal Tgif is required for vascularization of the embryonic placenta","volume":"319","author":"Bartholin","year":"2008","journal-title":"Dev Biol"},{"key":"key\n\t\t\t\t20170511064723_GAT042C3","doi-asserted-by":"crossref","first-page":"31178","DOI":"10.1074\/jbc.270.52.31178","article-title":"A novel homeobox protein which recognizes a TGT core and functionally interferes with a retinoid-responsive motif","volume":"270","author":"Bertolino","year":"1995","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170511064723_GAT042C50","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1741-7007-1-1","article-title":"Incorporation of gene-specific variability improves expression analysis using high-density DNA microarrays","volume":"1","author":"Budhraja","year":"2003","journal-title":"BMC Biol"},{"key":"key\n\t\t\t\t20170511064723_GAT042C4","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1067\/mob.2002.125243","article-title":"Decreased vascularization and cell proliferation in placentas of intrauterine growth-restricted fetuses with abnormal umbilical artery flow velocity waveforms","volume":"187","author":"Chen","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170511064723_GAT042C5","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.placenta.2011.07.007","article-title":"Homeobox gene distalless 3 (DLX3) is a regulator of villous cytotrotrophoblast differentiation","volume":"32","author":"Chui","year":"2011","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170511064723_GAT042C6","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1006\/scdb.2000.0156","article-title":"Genetic insights into trophoblast differentiation and placental morphogenesis","volume":"11","author":"Cross","year":"2000","journal-title":"Semin Cell Dev Biol"},{"key":"key\n\t\t\t\t20170511064723_GAT042C7","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1126\/science.7985020","article-title":"Implantation and the placenta: key pieces of the development puzzle","volume":"266","author":"Cross","year":"1994","journal-title":"Science"},{"key":"key\n\t\t\t\t20170511064723_GAT042C8","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.ymgme.2006.07.011","article-title":"Functional analysis of mutations in TGIF associated with holoprosencephaly","volume":"90","author":"El-Jaick","year":"2007","journal-title":"Mol Genet Metab"},{"issue":"Suppl. 3","key":"key\n\t\t\t\t20170511064723_GAT042C9","first-page":"326","article-title":"Intrauterine growth retardation (IUGR): prenatal diagnosis by imaging","volume":"6","author":"Falo","year":"2009","journal-title":"Pediatr Endocrinol Rev"},{"key":"key\n\t\t\t\t20170511064723_GAT042C10","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1006\/geno.2001.6532","article-title":"ESX1L, a novel X chromosome-linked human homeobox gene expressed in the placenta and testis","volume":"74","author":"Fohn","year":"2001","journal-title":"Genomics"},{"key":"key\n\t\t\t\t20170511064723_GAT042C11","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1515\/JPM.2007.082","article-title":"Intrauterine growth restriction and risk for arterial hypertension: a causal relationship?","volume":"35","author":"Gortner","year":"2007","journal-title":"J Perinat Med"},{"key":"key\n\t\t\t\t20170511064723_GAT042C12","first-page":"1384","article-title":"Retinoid receptors expression in human term placenta: involvement of RXR alpha in retinoid induced-hCG secretion","volume":"83","author":"Guibourdenche","year":"1998","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t20170511064723_GAT042C51","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.bbagrm.2008.04.003","article-title":"Genomic structure, alternative splicing and expression of TG-interacting factor, in human myeloid leukemia blasts and cell lines","volume":"1779","author":"Hamid","year":"2008","journal-title":"Biochim Biophys Acta"},{"key":"key\n\t\t\t\t20170511064723_GAT042C13","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.molonc.2009.07.004","article-title":"Transforming growth-interacting factor (TGIF) regulates proliferation and differentiation of human myeloid leukemia cells","volume":"3","author":"Hamid","year":"2009","journal-title":"Mol Oncol"},{"key":"key\n\t\t\t\t20170511064723_GAT042C14","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.placenta.2006.01.019","article-title":"Human chorionic gonadotropin expression in human trophoblasts from early placenta: comparative study between villous and extravillous trophoblastic cells","volume":"28","author":"Handschuh","year":"2007","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170511064723_GAT042C15","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.micron.2005.12.011","article-title":"Trophoblast fusion: fusogenic proteins, syncytins and ADAMs, and other prerequisites for syncytial fusion","volume":"37","author":"Huppertz","year":"2006","journal-title":"Micron"},{"key":"key\n\t\t\t\t20170511064723_GAT042C16","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1067\/mob.2002.119176","article-title":"Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation","volume":"186","author":"Ishihara","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170511064723_GAT042C17","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1002\/(SICI)1520-6408(1999)25:2<146::AID-DVG9>3.0.CO;2-K","article-title":"A repertoire of differentially expressed transcription factors that offers insight into mechanisms of human cytotrophoblast differentiation","volume":"25","author":"Janatpour","year":"1999","journal-title":"Dev Genet"},{"key":"key\n\t\t\t\t20170511064723_GAT042C18","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1530\/rep.1.01076","article-title":"TGF-beta superfamily expression and actions in the endometrium and placenta","volume":"132","author":"Jones","year":"2006","journal-title":"Reproduction"},{"key":"key\n\t\t\t\t20170511064723_GAT042C19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1095\/biolreprod.102.014977","article-title":"Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia","volume":"69","author":"Kaufmann","year":"2003","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20170511064723_GAT042C20","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1016\/S0002-9378(96)70103-5","article-title":"Intrauterine growth restriction with absent end-diastolic flow velocity in the umbilical artery is associated with maldevelopment of the placental terminal villous tree","volume":"175","author":"Krebs","year":"1996","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170511064723_GAT042C21","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1067\/mob.2002.122250","article-title":"Trophoblast apoptosis from pregnancies complicated by fetal growth restriction is associated with enhanced p53 expression","volume":"186","author":"Levy","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t20170511064723_GAT042C22","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/3129","article-title":"Esx1 is an X-chromosome-imprinted regulator of placental development and fetal growth","volume":"20","author":"Li","year":"1998","journal-title":"Nat Genet"},{"key":"key\n\t\t\t\t20170511064723_GAT042C23","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1093\/emboj\/19.8.1745","article-title":"Transcriptional control by the TGF-beta\/Smad signaling system","volume":"19","author":"Massague","year":"2000","journal-title":"EMBO J"},{"key":"key\n\t\t\t\t20170511064723_GAT042C24","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/35001608","article-title":"Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis","volume":"403","author":"Mi","year":"2000","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170511064723_GAT042C25","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1053\/j.semperi.2008.04.010","article-title":"Fetal growth restriction","volume":"32","author":"Miller","year":"2008","journal-title":"Semin Perinatol"},{"key":"key\n\t\t\t\t20170511064723_GAT042C26","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1073\/pnas.96.1.162","article-title":"Placental failure in mice lacking the homeobox gene Dlx3","volume":"96","author":"Morasso","year":"1999","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20170511064723_GAT042C27","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0165-0378(98)00021-7","article-title":"Functional regulation of human trophoblast differentiation","volume":"39","author":"Morrish","year":"1998","journal-title":"J Reprod Immunol"},{"key":"key\n\t\t\t\t20170511064723_GAT042C28","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.placenta.2004.07.006","article-title":"Fetal growth restriction is associated with increased apoptosis in the chorionic trophoblast cells of human fetal membranes","volume":"26","author":"Murthi","year":"2005","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170511064723_GAT042C29","doi-asserted-by":"crossref","first-page":"511","DOI":"10.2353\/ajpath.2006.050637","article-title":"Homeobox gene HLX1 expression is decreased in idiopathic human fetal growth restriction","volume":"168","author":"Murthi","year":"2006","journal-title":"Am J Pathol"},{"key":"key\n\t\t\t\t20170511064723_GAT042C30","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/molehr\/gal037","article-title":"Homeobox gene ESX1L expression is decreased in human pre-term idiopathic fetal growth restriction","volume":"12","author":"Murthi","year":"2006","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t20170511064723_GAT042C31","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1093\/molehr\/gal087","article-title":"Homeobox gene DLX4 expression is increased in idiopathic human fetal growth restriction","volume":"12","author":"Murthi","year":"2006","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t20170511064723_GAT042C32","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.placenta.2008.04.006","article-title":"Novel homeobox genes are differentially expressed in placental microvascular endothelial cells compared with macrovascular cells","volume":"29","author":"Murthi","year":"2008","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170511064723_GAT042C33","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/j.placenta.2007.04.008","article-title":"In vitro differentiation of villous trophoblasts from pregnancies complicated by intrauterine growth restriction with and without pre-eclampsia","volume":"28","author":"Newhouse","year":"2007","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170511064723_GAT042C34","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0143-4004(98)90103-5","article-title":"A distal-less class homeobox gene, DLX4, is a candidate for regulating epithelial-mesenchymal cell interactions in the human placenta","volume":"19","author":"Quinn","year":"1998","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170511064723_GAT042C35","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1016\/j.placenta.2007.03.011","article-title":"Homeobox gene HLX1 is a regulator of colony stimulating factor-1 dependent trophoblast cell proliferation","volume":"28","author":"Rajaraman","year":"2007","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170511064723_GAT042C36","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.placenta.2004.06.013","article-title":"Microarray-based identification of differentially expressed genes in hypoxic term human trophoblasts and in placental villi of pregnancies with growth restricted fetuses","volume":"26","author":"Roh","year":"2005","journal-title":"Placenta"},{"key":"key\n\t\t\t\t20170511064723_GAT042C37","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/35080570","article-title":"Placental development: lessons from mouse mutants","volume":"2","author":"Rossant","year":"2001","journal-title":"Nat Rev Genet"},{"key":"key\n\t\t\t\t20170511064723_GAT042C38","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.bpobgyn.2009.05.003","article-title":"Aetiology and pathogenesis of IUGR","volume":"23","author":"Sankaran","year":"2009","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"key\n\t\t\t\t20170511064723_GAT042C39","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.exer.2008.09.007","article-title":"TGIF, a homeodomain transcription factor, regulates retinal progenitor cell differentiation","volume":"87","author":"Satoh","year":"2008","journal-title":"Exp Eye Res"},{"key":"key\n\t\t\t\t20170511064723_GAT042C40","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat Protoc"},{"key":"key\n\t\t\t\t20170511064723_GAT042C41","doi-asserted-by":"crossref","first-page":"e1000073","DOI":"10.1371\/journal.pgen.1000073","article-title":"HOXA13 is essential for placental vascular patterning and labyrinth endothelial specification","volume":"4","author":"Shaut","year":"2008","journal-title":"PLoS Genet"},{"key":"key\n\t\t\t\t20170511064723_GAT042C42","doi-asserted-by":"crossref","first-page":"4504","DOI":"10.1210\/endo.142.10.8448","article-title":"PPAR gamma\/RXR alpha heterodimers are involved in human CG beta synthesis and human trophoblast differentiation","volume":"142","author":"Tarrade","year":"2001","journal-title":"Endocrinology"},{"key":"key\n\t\t\t\t20170511064723_GAT042C43","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1126\/science.282.5393.1501","article-title":"A rapidly evolving homeobox at the site of a hybrid sterility gene","volume":"282","author":"Ting","year":"1998","journal-title":"Science"},{"key":"key\n\t\t\t\t20170511064723_GAT042C44","first-page":"145","article-title":"Smad transcriptional corepressors in TGF beta family signaling","volume":"254","author":"Wotton","year":"2001","journal-title":"Curr Top Microbiol Immunol"},{"key":"key\n\t\t\t\t20170511064723_GAT042C45","doi-asserted-by":"crossref","first-page":"37105","DOI":"10.1074\/jbc.274.52.37105","article-title":"Multiple modes of repression by the Smad transcriptional corepressor TGIF","volume":"274","author":"Wotton","year":"1999","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20170511064723_GAT042C46","first-page":"457","article-title":"The Smad transcriptional corepressor TGIF recruits mSin3","volume":"12","author":"Wotton","year":"2001","journal-title":"Cell Growth Differ"},{"key":"key\n\t\t\t\t20170511064723_GAT042C47","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.siny.2004.03.005","article-title":"Paediatric consequences of fetal growth restriction","volume":"9","author":"Yanney","year":"2004","journal-title":"Semin Fetal Neonatal Med"},{"key":"key\n\t\t\t\t20170511064723_GAT042C48","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000204104","article-title":"Negative functional interaction of retinoic acid and TGF-beta signaling mediated by TG-interacting factor during chondrogenesis","volume":"23","author":"Zhang","year":"2009","journal-title":"Cell Physiol Biochem"},{"key":"key\n\t\t\t\t20170511064723_GAT042C49","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1530\/rep.1.01112","article-title":"Dual effect of transforming growth factor beta1 on cell adhesion and invasion in human placenta trophoblast cells","volume":"132","author":"Zhao","year":"2006","journal-title":"Reproduction"}],"container-title":["MHR: Basic science of reproductive medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/molehr\/article-pdf\/19\/10\/665\/12734784\/gat042.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,23]],"date-time":"2017-08-23T14:19:26Z","timestamp":1503497966000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/molehr\/article-lookup\/doi\/10.1093\/molehr\/gat042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,11]]},"references-count":51,"journal-issue":{"issue":"10","published-online":{"date-parts":[[2013,6,11]]},"published-print":{"date-parts":[[2013,10]]}},"URL":"https:\/\/doi.org\/10.1093\/molehr\/gat042","relation":{},"ISSN":["1460-2407","1360-9947"],"issn-type":[{"value":"1460-2407","type":"electronic"},{"value":"1360-9947","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6,11]]}}}