{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T20:46:56Z","timestamp":1792442816173,"version":"4.5.0"},"reference-count":91,"publisher":"Oxford University Press (OUP)","funder":[{"name":"National Health and Medical Research Council (NHMRC)","award":["#1101871"],"award-info":[{"award-number":["#1101871"]}]},{"name":"National Health and Medical Research Council (NHMRC)","award":["#1061977"],"award-info":[{"award-number":["#1061977"]}]},{"name":"National Health and Medical Research Council (NHMRC)","award":["#1050765"],"award-info":[{"award-number":["#1050765"]}]},{"name":"National Health and Medical Research Council (NHMRC)","award":["#1062418"],"award-info":[{"award-number":["#1062418"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mol. Hum. Reprod."],"DOI":"10.1093\/molehr\/gaw077","type":"journal-article","created":{"date-parts":[[2016,12,9]],"date-time":"2016-12-09T20:06:38Z","timestamp":1481313998000},"source":"Crossref","is-referenced-by-count":50,"title":["Placental-specific sFLT-1: role in pre-eclamptic pathophysiology and its translational possibilities for clinical prediction and diagnosis"],"prefix":"10.1093","author":[{"given":"K.R.","family":"Palmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.J.","family":"Kaitu'u-Lino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2016,12,16]]},"reference":[{"key":"2016122817155470000_gaw077v2.1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000147365.86159.f5"},{"key":"2016122817155470000_gaw077v2.2","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3109\/10641955.2016.1167219","article-title":"Prediction of preeclampsia with angiogenic biomarkers. Results from the prospective odense child cohort","volume":"35","author":"Andersen","year":"2016","journal-title":"Hypertens Pregnancy"},{"key":"2016122817155470000_gaw077v2.3","doi-asserted-by":"crossref","first-page":"428, e421","DOI":"10.1016\/j.ajog.2007.10.783","article-title":"Twin pregnancy and the risk of preeclampsia: bigger placenta or relative ischemia","volume":"198","author":"Bdolah","year":"2008","journal-title":"Am J Obstet Gynecol"},{"key":"2016122817155470000_gaw077v2.4","doi-asserted-by":"crossref","first-page":"469, e461","DOI":"10.1016\/j.ajog.2011.06.058","article-title":"Angiogenic factors as diagnostic tests for preeclampsia: a performance comparison between two commercial immunoassays","volume":"205","author":"Benton","year":"2011","journal-title":"Am J Obstet Gynecol"},{"key":"2016122817155470000_gaw077v2.5","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1111\/j.1582-4934.2009.00820.x","article-title":"Reduction of circulating soluble Flt-1 alleviates preeclampsia-like symptoms in a mouse model","volume":"14","author":"Bergmann","year":"2010","journal-title":"J Cell Mol Med"},{"key":"2016122817155470000_gaw077v2.6","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1008098108"},{"key":"2016122817155470000_gaw077v2.7","doi-asserted-by":"crossref","first-page":"356, e351","DOI":"10.1016\/j.ajog.2015.12.019","article-title":"Metformin as a prevention and treatment for preeclampsia: effects on soluble fms-like tyrosine kinase 1 and soluble endoglin secretion and endothelial dysfunction","volume":"214","author":"Brownfoot","year":"2016","journal-title":"Am J Obstet Gynecol"},{"key":"2016122817155470000_gaw077v2.8","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.115.05445"},{"key":"2016122817155470000_gaw077v2.9","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.mce.2015.06.033","article-title":"YC-1 reduces placental sFlt-1 and soluble endoglin production and decreases endothelial dysfunction: a possible therapeutic for preeclampsia","volume":"413","author":"Brownfoot","year":"2015","journal-title":"Mol Cell Endocrinol"},{"key":"2016122817155470000_gaw077v2.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.03.043"},{"key":"2016122817155470000_gaw077v2.11","doi-asserted-by":"publisher","DOI":"10.1097\/00003081-198412000-00004"},{"key":"2016122817155470000_gaw077v2.12","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313237200"},{"key":"2016122817155470000_gaw077v2.13","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod59.6.1540"},{"key":"2016122817155470000_gaw077v2.14","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0707330"},{"key":"2016122817155470000_gaw077v2.15","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200317423"},{"key":"2016122817155470000_gaw077v2.16","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.38.23659"},{"key":"2016122817155470000_gaw077v2.17","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.107.096594"},{"key":"2016122817155470000_gaw077v2.18","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc052954"},{"key":"2016122817155470000_gaw077v2.19","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2007-1550"},{"key":"2016122817155470000_gaw077v2.20","doi-asserted-by":"crossref","first-page":"5450","DOI":"10.1167\/iovs.14-16248","article-title":"MMP14 cleavage of VEGFR1 in the cornea leads to a VEGF-trap antiangiogenic effect","volume":"56","author":"Han","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"2016122817155470000_gaw077v2.21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.35.25130"},{"key":"2016122817155470000_gaw077v2.22","doi-asserted-by":"publisher","DOI":"10.1210\/me.13.4.537"},{"key":"2016122817155470000_gaw077v2.23","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.036715"},{"key":"2016122817155470000_gaw077v2.24","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2008.12.010"},{"key":"2016122817155470000_gaw077v2.25","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.114.013740"},{"key":"2016122817155470000_gaw077v2.26","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.110.164079"},{"key":"2016122817155470000_gaw077v2.27","unstructured":"Johnson S , Bonello M , Li Z , Hilder L , Sullivan E. Maternal deaths in Australia 2006\u20132010 . Canberra: Australian Institute of Health and Welfare, 2014, Maternal death series no.4; Cat no. PER 61."},{"key":"2016122817155470000_gaw077v2.28","doi-asserted-by":"publisher","DOI":"10.1038\/ki.2011.288"},{"key":"2016122817155470000_gaw077v2.29","doi-asserted-by":"crossref","first-page":"e181","DOI":"10.1016\/j.ajog.2009.09.005","article-title":"Angiogenic dysfunction in molar pregnancy","volume":"202","author":"Kanter","year":"2010","journal-title":"Am J Obstet Gynecol"},{"key":"2016122817155470000_gaw077v2.30","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.22.10705"},{"key":"2016122817155470000_gaw077v2.31","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1994.1705"},{"key":"2016122817155470000_gaw077v2.32","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.02.015"},{"key":"2016122817155470000_gaw077v2.33","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1011293108"},{"key":"2016122817155470000_gaw077v2.34","doi-asserted-by":"publisher","DOI":"10.1126\/science.2479986"},{"key":"2016122817155470000_gaw077v2.35","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa031884"},{"key":"2016122817155470000_gaw077v2.36","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.10.192"},{"key":"2016122817155470000_gaw077v2.37","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.placenta.2015.01.004","article-title":"Aspirin inhibits expression of sFLT1 from human cytotrophoblasts induced by hypoxia, via cyclo-oxygenase 1","volume":"36","author":"Li","year":"2015","journal-title":"Placenta"},{"key":"2016122817155470000_gaw077v2.38","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s00404-015-3671-8","article-title":"Diagnostic accuracy of the soluble Fms-like tyrosine kinase-1\/placental growth factor ratio for preeclampsia: a meta-analysis based on 20 studies","volume":"292","author":"Liu","year":"2015","journal-title":"Arch Gynecol Obstet"},{"key":"2016122817155470000_gaw077v2.39","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2000.108022"},{"key":"2016122817155470000_gaw077v2.40","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2007.03.004"},{"key":"2016122817155470000_gaw077v2.41","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ki.5002175"},{"key":"2016122817155470000_gaw077v2.42","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1645"},{"key":"2016122817155470000_gaw077v2.43","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200317189"},{"key":"2016122817155470000_gaw077v2.44","doi-asserted-by":"crossref","first-page":"53 e51","DOI":"10.1016\/j.ajog.2013.03.017","article-title":"Gestational angiogenic biomarker patterns in high risk preeclampsia groups","volume":"209","author":"Maynard","year":"2013","journal-title":"Am J Obstet Gynecol"},{"key":"2016122817155470000_gaw077v2.45","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.03.004"},{"key":"2016122817155470000_gaw077v2.46","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(97)01259-3"},{"key":"2016122817155470000_gaw077v2.47","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00070-7"},{"key":"2016122817155470000_gaw077v2.48","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11906-015-0595-4","article-title":"Preeclampsia: syndrome or disease","volume":"17","author":"Myatt","year":"2015","journal-title":"Curr Hypertens Rep"},{"key":"2016122817155470000_gaw077v2.49","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-0533"},{"key":"2016122817155470000_gaw077v2.50","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(96)70056-X"},{"key":"2016122817155470000_gaw077v2.51","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc052954"},{"key":"2016122817155470000_gaw077v2.52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14767058.2016.1182975","article-title":"Maternal plasma concentrations of the placental specific sFLT-1 variant, sFLT-1 e15a, in fetal growth restriction and preeclampsia","volume":"16","author":"Palmer","year":"2016","journal-title":"J Matern Fetal Neonatal Med"},{"key":"2016122817155470000_gaw077v2.53","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1161\/HYPERTENSIONAHA.115.05883","article-title":"Placental-specific sFLT-1 e15a protein is increased in preeclampsia, antagonizes vascular endothelial growth factor signaling, and has antiangiogenic activity","volume":"66","author":"Palmer","year":"2015","journal-title":"Hypertension"},{"key":"2016122817155470000_gaw077v2.54","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.115.134460"},{"key":"2016122817155470000_gaw077v2.55","doi-asserted-by":"crossref","first-page":"25646","DOI":"10.1016\/S0021-9258(18)47298-5","article-title":"Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1\/KDR","volume":"269","author":"Park","year":"1994","journal-title":"J Biol Chem"},{"key":"2016122817155470000_gaw077v2.56","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1999.1580"},{"key":"2016122817155470000_gaw077v2.57","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2004.11.038"},{"key":"2016122817155470000_gaw077v2.58","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-2905"},{"key":"2016122817155470000_gaw077v2.59","doi-asserted-by":"crossref","first-page":"e112794","DOI":"10.1371\/journal.pone.0112794","article-title":"N-terminal cleavage and release of the ectodomain of Flt1 is mediated via ADAM10 and ADAM 17 and regulated by VEGFR2 and the Flt1 intracellular domain","volume":"9","author":"Raikwar","year":"2014","journal-title":"PLoS One"},{"key":"2016122817155470000_gaw077v2.60","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.yexcr.2016.03.020","article-title":"Ectodomain cleavage of FLT1 regulates receptor activation and function and is not required for its downstream intracellular cleavage","volume":"344","author":"Raikwar","year":"2016","journal-title":"Exp Cell Res"},{"key":"2016122817155470000_gaw077v2.61","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2004.09.001"},{"key":"2016122817155470000_gaw077v2.62","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-252684"},{"key":"2016122817155470000_gaw077v2.63","doi-asserted-by":"publisher","DOI":"10.1097\/OGX.0b013e3182331028"},{"key":"2016122817155470000_gaw077v2.64","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(14)70227-X"},{"key":"2016122817155470000_gaw077v2.65","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinbiochem.2010.02.010"},{"key":"2016122817155470000_gaw077v2.66","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.108.171504"},{"key":"2016122817155470000_gaw077v2.67","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-1955"},{"key":"2016122817155470000_gaw077v2.68","first-page":"519","article-title":"Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family","volume":"5","author":"Shibuya","year":"1990","journal-title":"Oncogene"},{"key":"2016122817155470000_gaw077v2.69","doi-asserted-by":"crossref","first-page":"12436","DOI":"10.3390\/ijms160612436","article-title":"Circulating levels of sFlt1 splice variants as predictive markers for the development of preeclampsia","volume":"16","author":"Souders","year":"2015","journal-title":"Int J Mol Sci"},{"key":"2016122817155470000_gaw077v2.70","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(10)60279-6"},{"key":"2016122817155470000_gaw077v2.71","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C300012200"},{"key":"2016122817155470000_gaw077v2.72","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.04.003"},{"key":"2016122817155470000_gaw077v2.73","doi-asserted-by":"crossref","first-page":"e0119547","DOI":"10.1371\/journal.pone.0119547","article-title":"Full-length human placental sFlt-1-e15a isoform induces distinct maternal phenotypes of preeclampsia in mice","volume":"10","author":"Szalai","year":"2015","journal-title":"PLoS One"},{"key":"2016122817155470000_gaw077v2.74","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0110867"},{"key":"2016122817155470000_gaw077v2.75","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.090800"},{"key":"2016122817155470000_gaw077v2.76","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2015020157"},{"key":"2016122817155470000_gaw077v2.77","doi-asserted-by":"publisher","DOI":"10.1096\/fj.07-8809com"},{"key":"2016122817155470000_gaw077v2.78","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2009-0017"},{"key":"2016122817155470000_gaw077v2.79","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(11)91665-2"},{"key":"2016122817155470000_gaw077v2.80","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.preghy.2014.02.001","article-title":"The classification, diagnosis and management of the hypertensive disorders of pregnancy: a revised statement from the ISSHP","volume":"4","author":"Tranquilli","year":"2014","journal-title":"Pregnancy Hypertens"},{"key":"2016122817155470000_gaw077v2.81","doi-asserted-by":"crossref","unstructured":"Vatish M , Strunz-McKendry T , Hund M , Allegranza D , Wolf C , Smare C . The sflt-1\/plgf ratio test in pre-eclampsia: an economic assessment for the UK. Ultrasound Obstet Gynecol 2016.","DOI":"10.1002\/uog.15997"},{"key":"2016122817155470000_gaw077v2.82","doi-asserted-by":"publisher","DOI":"10.1038\/nm1429"},{"key":"2016122817155470000_gaw077v2.83","doi-asserted-by":"publisher","DOI":"10.1042\/CS20110097"},{"key":"2016122817155470000_gaw077v2.84","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1182\/blood.V95.11.3387","article-title":"Up-regulation of vascular endothelial growth factor receptor Flt-1 after endothelial denudation: role of transcription factor Egr-1","volume":"95","author":"Vidal","year":"2000","journal-title":"Blood"},{"key":"2016122817155470000_gaw077v2.85","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1471-2393-13-110","article-title":"Vasoactive agents for the prediction of early- and late-onset preeclampsia in a high-risk cohort","volume":"13","author":"Villa","year":"2013","journal-title":"BMC Pregnancy Childbirth"},{"key":"2016122817155470000_gaw077v2.86","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2011.02962.x"},{"key":"2016122817155470000_gaw077v2.87","unstructured":"WHO World Health Report: Making Every Mother and Child Count. Geneva: World Health Organisation, 2005."},{"key":"2016122817155470000_gaw077v2.88","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)80456-0"},{"key":"2016122817155470000_gaw077v2.89","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000264552.85436.a1"},{"key":"2016122817155470000_gaw077v2.90","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21800"},{"key":"2016122817155470000_gaw077v2.91","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1414838"}],"container-title":["Molecular Human Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/molehr\/article-pdf\/23\/2\/69\/10258298\/gaw077.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T20:14:52Z","timestamp":1658002492000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/molehr\/article-lookup\/doi\/10.1093\/molehr\/gaw077"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12,16]]},"references-count":91,"alternative-id":["10.1093\/molehr\/gaw077"],"URL":"https:\/\/doi.org\/10.1093\/molehr\/gaw077","relation":{},"ISSN":["1360-9947","1460-2407"],"issn-type":[{"value":"1360-9947","type":"print"},{"value":"1460-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2016,12,16]]}}}