{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:12:03Z","timestamp":1793211123799,"version":"4.5.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","funder":[{"name":"NIH"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1093\/molehr\/gay003","type":"journal-article","created":{"date-parts":[[2018,1,20]],"date-time":"2018-01-20T15:07:54Z","timestamp":1516460874000},"source":"Crossref","is-referenced-by-count":30,"title":["Oviductal extracellular vesicles (oviductosomes, OVS) are conserved in humans: murine OVS play a pivotal role in sperm capacitation and fertility"],"prefix":"10.1093","author":[{"given":"Pradeepthi","family":"Bathala","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeinab","family":"Fereshteh","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA"},{"name":"Present address: Department of Reproductive Physiology, Zhejiang Academy of Medical Sciences, Room 205 B, Building 3, 182 Tian Mu Shan Road, Hangzhou, Zhejiang 310013, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amal A","family":"Al-Dossary","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA"},{"name":"Present address: Department of Biology, College of Medicine, University of Dammam (UOD), PO Box 2435, Dammam 31451, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deni S","family":"Galileo","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6903-3703","authenticated-orcid":false,"given":"Patricia A","family":"Martin-DeLeon","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2018,1,23]]},"reference":[{"key":"key\n\t\t\t\t20180224011041_gay003C1","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1095\/biolreprod.111.095760","article-title":"Identification of distinct populations of prostasomes that differentially express prostate stem cell antigen, annexin A1, and GLIPR2 in humans","volume":"86","author":"Aalberts","year":"2012","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20180224011041_gay003C2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/(SICI)1098-2795(199605)44:1<111::AID-MRD13>3.0.CO;2-7","article-title":"Evidence for Ca2+-dependent ATPase activity, stimulated by decapacitation factor and calmodulin, in mouse sperm","volume":"44","author":"Adeoya-Osiguwa","year":"1996","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20180224011041_gay003C3","doi-asserted-by":"crossref","first-page":"17710","DOI":"10.1074\/jbc.M114.633156","article-title":"Oviductosome-sperm membrane interaction in cargo delivery: detection of fusion and underlying molecular players using 3D super-resolution structured illumination microscopy (SR-SIM)","volume":"290","author":"Al-Dossary","year":"2015","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180224011041_gay003C4","doi-asserted-by":"crossref","first-page":"e80181","DOI":"10.1371\/journal.pone.0080181","article-title":"Expression and secretion of plasma membrane Ca2+-ATPase 4a (PMCA4a) during murine estrus: association with oviductal exosomes and uptake in sperm","volume":"8","author":"Al-Dossary","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180224011041_gay003C5","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1242\/dev.136499","article-title":"The tyrosine kinase FER is responsible for the capacitation-associated increase in tyrosine phosphorylation in murine sperm","volume":"143","author":"Alvau","year":"2016","journal-title":"Development"},{"key":"key\n\t\t\t\t20180224011041_gay003C6","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1093\/molehr\/gav049","article-title":"Plasma membrane Ca2+- ATPase 4: interaction with constitutive nitric oxide synthases in human sperm and prostasomes which carry Ca2+\/CaM-dependent serine kinase","volume":"21","author":"Andrews","year":"2015","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t20180224011041_gay003C7","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1002\/jcp.24000","article-title":"CASK interacts with PMCA4b and JAM-A on the mouse sperm flagellum to regulate Ca2+ homeostasis and motility","volume":"227","author":"Aravindan","year":"2012","journal-title":"J Cell Physiol"},{"key":"key\n\t\t\t\t20180224011041_gay003C8","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0940-9602(99)80020-X","article-title":"Apocrine secretion-fact or artifact?","volume":"181","author":"Aum\u00fcller","year":"1999","journal-title":"Ann Anat"},{"key":"key\n\t\t\t\t20180224011041_gay003C9","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1038\/170326a0","article-title":"The capacitation of the mammalian sperm","volume":"170","author":"Austin","year":"1952","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180224011041_gay003C10","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1242\/jcs.03055","article-title":"Identification of SRC as a key PKA-stimulated tyrosine kinase involved in the capacitation-associated hyperactivation of murine spermatozoa","volume":"119","author":"Baker","year":"2006","journal-title":"J Cell Sci"},{"key":"key\n\t\t\t\t20180224011041_gay003C11","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1095\/biolreprod.113.110486","article-title":"Epididymosomes convey different repertoires of microRNAs throughout the bovine epididymis","volume":"89","author":"Belleannee","year":"2013","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20180224011041_gay003C12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1095\/biolreprod.112.101253","article-title":"Involvement of bicarbonate-induced radical signaling in oxysterol formation and sterol depletion of capacitating mammalian sperm during in vitro fertilization","volume":"88","author":"Boerke","year":"2013","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20180224011041_gay003C13","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1095\/biolreprod.111.091207","article-title":"Mass spectrometric detection of cholesterol oxidation in bovine sperm","volume":"85","author":"Brouwers","year":"2011","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20180224011041_gay003C14","doi-asserted-by":"crossref","first-page":"e35538","DOI":"10.1371\/journal.pone.0035538","article-title":"Mouse estrous cycle identification tool and images","volume":"7","author":"Byers","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180224011041_gay003C15","first-page":"757194","article-title":"Post testicular sperm maturational changes in the bull: important role of the epididymosomes and prostasomes","volume":"2011","author":"Caballero","year":"2010","journal-title":"Vet Med Int"},{"key":"key\n\t\t\t\t20180224011041_gay003C16","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/1751036a0","article-title":"Development of fertilizing capacity of rabbit spermatozoa in the uterus","volume":"175","author":"Chang","year":"1955","journal-title":"Nature"},{"key":"key\n\t\t\t\t20180224011041_gay003C17","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1095\/biolreprod.105.048587","article-title":"Epididymal SPAM1 is a marker for sperm maturation in the mouse","volume":"74","author":"Chen","year":"2006","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20180224011041_gay003C18","first-page":"833","article-title":"Uterosome-like vesicles prompt human sperm fertilizing capability","volume":"22","author":"Franchi","year":"2016","journal-title":"Mol Hum Reprod"},{"key":"key\n\t\t\t\t20180224011041_gay003C19","doi-asserted-by":"crossref","first-page":"R1","DOI":"10.1530\/REP-14-0145","article-title":"Oviductal secretion and gamete interaction","volume":"149","author":"Ghersevich","year":"2015","journal-title":"Reproduction"},{"key":"key\n\t\t\t\t20180224011041_gay003C20","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1002\/mrd.20907","article-title":"Investigating the role of murine epididymosomes and uterosomes in GPI-linked protein transfer to sperm using SPAM1 as a model","volume":"75","author":"Griffiths","year":"2008","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20180224011041_gay003C21","doi-asserted-by":"crossref","first-page":"38141","DOI":"10.1074\/jbc.M302400200","article-title":"Expression, purification, and characterization of isoform 1 of the plasma membrane Ca2+ pump: focus on calpain sensitivity","volume":"278","author":"Guerini","year":"2003","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180224011041_gay003C22","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/mrd.90023","article-title":"Nature\u2019s ingenuity: bypassing the classical secretory route via apocrine secretion","volume":"63","author":"Hermo","year":"2002","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20180224011041_gay003C23","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1385\/1-59259-250-3:343","volume-title":"Calcium Signaling Protocols","author":"Kosk-Kosicka","year":"1999"},{"key":"key\n\t\t\t\t20180224011041_gay003C24","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1006\/jsbi.1996.0013","article-title":"Computer visualization of three-dimensional image data using IMOD","volume":"116","author":"Kremer","year":"1996","journal-title":"J Struct Biol"},{"key":"key\n\t\t\t\t20180224011041_gay003C25","doi-asserted-by":"crossref","first-page":"e0148083","DOI":"10.1371\/journal.pone.0148083","article-title":"Extracellular vesicles from BOEC in in vitro embryo development and quality","volume":"11","author":"Lopera-Vasquez","year":"2016","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180224011041_gay003C26","first-page":"182","article-title":"Extracellular vesicles: roles in gamete maturation, fertilization and embryo implantation","volume":"22","author":"Machtinger","year":"2016","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20180224011041_gay003C27","doi-asserted-by":"crossref","first-page":"720","DOI":"10.4103\/1008-682X.155538","article-title":"Epididymosomes: transfer of fertility-modulating proteins to the sperm surface","volume":"17","author":"Martin-DeLeon","year":"2015","journal-title":"Asian J Androl"},{"key":"key\n\t\t\t\t20180224011041_gay003C28","first-page":"79","volume-title":"Exosomes: Biogenesis, Therapeutic Applications and Emerging Research","author":"Martin-DeLeon","year":"2016"},{"key":"key\n\t\t\t\t20180224011041_gay003C29","doi-asserted-by":"crossref","first-page":"33742","DOI":"10.1074\/jbc.M404628200","article-title":"Targeted ablation of plasma membrane Ca2+-ATPase (PMCA) 1 and 4 indicates a major housekeeping function for PMCA1 and a critical role in hyperactivated sperm motility and male fertility for PMCA4","volume":"279","author":"Okunade","year":"2004","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180224011041_gay003C30","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/jcp.25882","article-title":"Plasma membrane calcium ATPase 4 (PMCA4) co-ordinates calcium and nitric oxide signaling in regulating murine sperm functional activity","volume":"233","author":"Olli","year":"2018","journal-title":"J Cell Physiol"},{"key":"key\n\t\t\t\t20180224011041_gay003C31","doi-asserted-by":"crossref","first-page":"9125","DOI":"10.1093\/nar\/gks656","article-title":"MicroRNAs are exported from malignant cells in customized particles","volume":"40","author":"Palma","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t20180224011041_gay003C32","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1095\/biolreprod.113.108712","article-title":"Plasma membrane Ca2+-ATPase 4 in murine epididymis: secretion of splice variants in the luminal fluid and a role in sperm maturation","volume":"89","author":"Patel","year":"2013","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20180224011041_gay003C33","doi-asserted-by":"crossref","first-page":"13368","DOI":"10.1073\/pnas.0403453101","article-title":"Identification and proteomic profiling of exosomes in human urine","volume":"101","author":"Pisitkun","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"key\n\t\t\t\t20180224011041_gay003C34","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1111\/j.1365-2605.2009.01022.x","article-title":"Arrangement of PMCA4 in bovine sperm membrane fractions","volume":"33","author":"Post","year":"2010","journal-title":"Int J Androl"},{"key":"key\n\t\t\t\t20180224011041_gay003C35","author":"Rasband","year":"1997"},{"key":"key\n\t\t\t\t20180224011041_gay003C36","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1083\/jcb.17.1.208","article-title":"The use of lead citrate at high pH as an electron-opaque stain in electron microscopy","volume":"17","author":"Reynolds","year":"1963","journal-title":"J Cell Biol"},{"key":"key\n\t\t\t\t20180224011041_gay003C37","first-page":"365","article-title":"Primer 3 on the WWW for general users and for biologist programmers","volume":"132","author":"Rozen","year":"2000","journal-title":"Methods Mol Biol"},{"key":"key\n\t\t\t\t20180224011041_gay003C38","doi-asserted-by":"crossref","first-page":"28220","DOI":"10.1074\/jbc.M312599200","article-title":"Plasma membrane Ca2+ ATPase 4 is required for sperm motility and male fertility","volume":"279","author":"Schuh","year":"2004","journal-title":"J Biol Chem"},{"key":"key\n\t\t\t\t20180224011041_gay003C39","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.ceb.2009.03.007","article-title":"Exosomes: vesicular carriers for intercellular communication","volume":"21","author":"Simons","year":"2009","journal-title":"Curr Opin Cell Biol"},{"key":"key\n\t\t\t\t20180224011041_gay003C40","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1042\/BST0350919","article-title":"Plasma-membrane Ca(2+) pumps: structural diversity as the basis for functional versatility","volume":"35","author":"Strehler","year":"2007","journal-title":"Biochem Soc Trans"},{"key":"key\n\t\t\t\t20180224011041_gay003C41","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nri2567","article-title":"Membrane vesicles as conveyors of immune responses","volume":"9","author":"Thery","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"key\n\t\t\t\t20180224011041_gay003C42","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/nri855","article-title":"Exosomes: composition, biogenesis and function","volume":"2","author":"Thery","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"key\n\t\t\t\t20180224011041_gay003C43","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1242\/dev.121.4.1139","article-title":"Capacitation of mouse sperm II. Protein tyrosine phosphorylation and capacitation are regulated by a cAMP-dependent pathway","volume":"121","author":"Visconti","year":"1995","journal-title":"Development"},{"key":"key\n\t\t\t\t20180224011041_gay003C44","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1085\/jgp.200308839","article-title":"Calcium clearance mechanisms of mouse sperm","volume":"122","author":"Wennemuth","year":"2003","journal-title":"J Gen Physiol"}],"container-title":["MHR: Basic science of reproductive medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/molehr\/advance-article-pdf\/doi\/10.1093\/molehr\/gay003\/24161176\/gay003.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T12:45:25Z","timestamp":1693485925000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/molehr\/advance-article\/doi\/10.1093\/molehr\/gay003\/4822017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,23]]},"references-count":44,"URL":"https:\/\/doi.org\/10.1093\/molehr\/gay003","relation":{},"ISSN":["1360-9947","1460-2407"],"issn-type":[{"value":"1360-9947","type":"print"},{"value":"1460-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,23]]}}}