{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:05:23Z","timestamp":1767852323278,"version":"3.49.0"},"reference-count":53,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2018,8,13]],"date-time":"2018-08-13T00:00:00Z","timestamp":1534118400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Grant for Fertility Innovation 2014"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"DOI":"10.1093\/molehr\/gay035","type":"journal-article","created":{"date-parts":[[2018,8,11]],"date-time":"2018-08-11T11:11:39Z","timestamp":1533985899000},"source":"Crossref","is-referenced-by-count":6,"title":["Does the molecular and metabolic profile of human granulosa cells correlate with oocyte fate? New insights by Fourier transform infrared microspectroscopy analysis"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1187-7302","authenticated-orcid":false,"given":"Giorgia","family":"Gioacchini","sequence":"first","affiliation":[{"name":"Department of Life and Environmental Sciences, Polytechnic University of Marche, Via Brecce Bianche, 60131 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4651-6235","authenticated-orcid":false,"given":"Valentina","family":"Notarstefano","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, Polytechnic University of Marche, Via Brecce Bianche, 60131 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Sereni","sequence":"additional","affiliation":[{"name":"9.baby, Family and Fertility Center, Via Dante, 15, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlotta","family":"Zac\u00e0","sequence":"additional","affiliation":[{"name":"9.baby, Family and Fertility Center, Via Dante, 15, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1635-9205","authenticated-orcid":false,"given":"Giovanni","family":"Coticchio","sequence":"additional","affiliation":[{"name":"9.baby, Family and Fertility Center, Via Dante, 15, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0503-5870","authenticated-orcid":false,"given":"Elisabetta","family":"Giorgini","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, Polytechnic University of Marche, Via Brecce Bianche, 60131 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa","family":"Vaccari","sequence":"additional","affiliation":[{"name":"SISSI Beamline, Elettra-Sincrotrone Trieste S.C.p.A., S.S.14, Km 163.5, 34149 Basovizza, Trieste, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5994-0572","authenticated-orcid":false,"given":"Oliana","family":"Carnevali","sequence":"additional","affiliation":[{"name":"Department of Life and Environmental Sciences, Polytechnic University of Marche, Via Brecce Bianche, 60131 Ancona, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9049-0020","authenticated-orcid":false,"given":"Andrea","family":"Borini","sequence":"additional","affiliation":[{"name":"9.baby, Family and Fertility Center, Via Dante, 15, Bologna, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,9,12]]},"reference":[{"key":"key\n\t\t\t\t20180912081316_gay035C1","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1093\/humrep\/deq049","article-title":"Cumulus cell gene expression is associated with oocyte developmental quality and influenced by patient and treatment characteristics","volume":"25","author":"Adriaenssens","year":"2010","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20180912081316_gay035C2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2014\/964614","article-title":"Female aging alters expression of human cumulus cells genes that are essential for oocyte quality","volume":"2014","author":"Al-Edani","year":"2014","journal-title":"Biomed Res Int"},{"key":"key\n\t\t\t\t20180912081316_gay035C3","first-page":"32","article-title":"A new method for non-parametric multivariate analysis of variance","volume":"26","author":"Anderson","year":"2001","journal-title":"Austral Ecol"},{"key":"key\n\t\t\t\t20180912081316_gay035C4","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/1467-842X.00285","article-title":"Generalized discriminant analysis based on distances","volume":"45","author":"Anderson","year":"2003","journal-title":"Aust New Zeal J Stat"},{"key":"key\n\t\t\t\t20180912081316_gay035C5","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1890\/0012-9658(2003)084[0511:CAOPCA]2.0.CO;2","article-title":"Canonical analysis of principal coordinates: a useful method of contrained ordination for ecology","volume":"84","author":"Anderson","year":"2003","journal-title":"Ecology"},{"key":"key\n\t\t\t\t20180912081316_gay035C6","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1038\/nprot.2014.110","article-title":"Using Fourier transform IR spectroscopy to analyze biological materials","volume":"9","author":"Baker","year":"2014","journal-title":"Nat Protoc"},{"key":"key\n\t\t\t\t20180912081316_gay035C1000","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1002\/jbio.200810062","article-title":"Investigating FTIR based histopathology for the diagnosis of prostate cancer","volume":"2","author":"Baker","year":"2009","journal-title":"J Biophotonics"},{"key":"key\n\t\t\t\t20180912081316_gay035C7","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/S1472-6483(10)61187-X","article-title":"Effect of oocyte morphology on embryo development and implantation","volume":"12","author":"Balaban","year":"2006","journal-title":"Reprod Biomed Online"},{"key":"key\n\t\t\t\t20180912081316_gay035C8","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1093\/humrep\/13.12.3431","article-title":"Oocyte morphology does not affect fertilization rate, embryo quality and implantation rate after intracytoplasmic sperm injection","volume":"13","author":"Balaban","year":"1998","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20180912081316_gay035C9","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1093\/HUMREP\/11.3.548","article-title":"Oocyte donation programme: results obtained with intracytoplasmic sperm injection in cases of severe male factor infertility or previous failed fertilization","volume":"11","author":"Borini","year":"1996","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20180912081316_gay035C10","doi-asserted-by":"crossref","first-page":"e0153562","DOI":"10.1371\/journal.pone.0153562","article-title":"Competence classification of cumulus and granulosa cell transcriptome in embryos matched by morphology and female age","volume":"11","author":"Borup","year":"2016","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180912081316_gay035C11","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1210\/er.2009-0006","article-title":"Ovarian aging: mechanisms and clinical consequences","volume":"30","author":"Broekmans","year":"2009","journal-title":"Endocr Rev"},{"key":"key\n\t\t\t\t20180912081316_gay035C12","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/0012-1606(82)90219-6","article-title":"Intercellular communication between granulosa cells and mouse oocytes: existence and possible nutritional role during oocyte growth","volume":"90","author":"Brower","year":"1982","journal-title":"Dev Biol"},{"key":"key\n\t\t\t\t20180912081316_gay035C2000","doi-asserted-by":"crossref","first-page":"3624","DOI":"10.1016\/j.neuroimage.2011.11.033","article-title":"The application of Fourier transform infrared microspectroscopy for the study of diseased central nervous system tissue","volume":"59","author":"Caine","year":"2012","journal-title":"Neuroimage"},{"key":"key\n\t\t\t\t20180912081316_gay035C13","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1093\/humupd\/6.3.279","article-title":"Oocyte-granulosa cell interactions","volume":"6","author":"Canipari","year":"2000","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20180912081316_gay035C14","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/jez.1402580216","article-title":"Granulosa cell-oocyte interactions: the phosphorylation of specific proteins in mouse oocytes at the germinal vesicle stage is dependent upon the differentiative state of companion somatic cells","volume":"258","author":"Cecconi","year":"1991","journal-title":"J Exp Zool"},{"key":"key\n\t\t\t\t20180912081316_gay035C15","doi-asserted-by":"crossref","first-page":"213570","DOI":"10.1155\/2014\/213570","article-title":"High-throughput analysis of ovarian granulosa cell transcriptome","volume":"2014","author":"Chronowska","year":"2014","journal-title":"Biomed Res Int"},{"key":"key\n\t\t\t\t20180912081316_gay035C16","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1016\/j.fertnstert.2007.05.050","article-title":"Comparison of concomitant outcome achieved with fresh and cryopreserved donor oocytes vitrified by the Cryotop method","volume":"89","author":"Cobo","year":"2008","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20180912081316_gay035C17","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/0012-1606(89)90321-7","article-title":"Somatic cell-oocyte interactions in mouse oogenesis: stage specific regulation of mouse oocyte protein phosphorylation by granulosa cells","volume":"133","author":"Colonna","year":"1989","journal-title":"Dev Biol"},{"key":"key\n\t\t\t\t20180912081316_gay035C3000","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.molstruc.2006.10.060","article-title":"Microimaging FT-IR of oral cavity tumours. Part III: cells, inoculated tissues and human tissues","volume":"834\u2013836","author":"Conti","year":"2007","journal-title":"J Mol Struct"},{"key":"key\n\t\t\t\t20180912081316_gay035C18","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1006\/dbio.2000.9947","article-title":"Transcriptional activity of the mouse oocyte genome: companion granulosa cells modulate transcription and chromatin remodeling","volume":"229","author":"De La Fuente","year":"2001","journal-title":"Dev Biol"},{"key":"key\n\t\t\t\t20180912081316_gay035C19","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.fertnstert.2014.11.015","article-title":"Oocyte environment: follicular fluid and cumulus cells are critical for oocyte health","volume":"103","author":"Dumesic","year":"2015","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20180912081316_gay035C20","doi-asserted-by":"crossref","first-page":"R15","DOI":"10.1530\/REP-13-0251","article-title":"Lipids and oocyte developmental competence: the role of fatty acids and \u03b2-oxidation","volume":"148","author":"Dunning","year":"2014","journal-title":"Reproduction"},{"key":"key\n\t\t\t\t20180912081316_gay035C21","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1080\/09513590.2016.1223288","article-title":"Inside the granulosa transcriptome","volume":"32","author":"D\u2019Aurora","year":"2016","journal-title":"Gynecol Endocrinol"},{"key":"key\n\t\t\t\t20180912081316_gay035C22","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/bies.950131105","article-title":"Intercommunication between mammalian oocytes and companion somatic cells","volume":"13","author":"Eppig","year":"1991","journal-title":"Bioessays"},{"key":"key\n\t\t\t\t20180912081316_gay035C23","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1095\/biolreprod.112.106617","article-title":"Cigarette smoke exposure elicits increased autophagy and dysregulation of mitochondrial dynamics in murine granulosa cells","volume":"88","author":"Gannon","year":"2013","journal-title":"Biol Reprod"},{"key":"key\n\t\t\t\t20180912081316_gay035C24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/humupd\/dmm040","article-title":"Oocyte-secreted factors: regulators of cumulus cell function and oocyte quality","volume":"14","author":"Gilchrist","year":"2008","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t20180912081316_gay035C25","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.fertnstert.2013.09.012","article-title":"A new approach to evaluate aging effects on human oocytes: Fourier transform infrared imaging spectroscopy study","volume":"101","author":"Gioacchini","year":"2014","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20180912081316_gay035C26","doi-asserted-by":"crossref","first-page":"5049","DOI":"10.1039\/C4AN00684D","article-title":"Vibrational characterization of female gametes: a comparative study","volume":"139","author":"Giorgini","year":"2014","journal-title":"Analyst"},{"key":"key\n\t\t\t\t20180912081316_gay035C6000","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.saa.2015.01.052","article-title":"Molecular and Biomolecular Spectroscopy FTIR microspectroscopic characterization of Spitz nevi","volume":"141","author":"Giorgini","year":"2015","journal-title":"Spectrochim Acta Part A Mol Biomol Spectrosc"},{"key":"key\n\t\t\t\t20180912081316_gay035C27","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.fertnstert.2009.02.074","article-title":"FSH receptor, KL1\/2, P450, and PAPP genes in granulosa-lutein cells from in vitro fertilization patients show a different expression pattern depending on the infertility diagnosis","volume":"94","author":"Gonz\u00e1lez-Fern\u00e1ndez","year":"2010","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20180912081316_gay035C28","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.rbmo.2010.06.043","article-title":"Does early morphology provide additional selection power to blastocyst selection for transfer?","volume":"21","author":"Guerif","year":"2010","journal-title":"Reprod Biomed Online"},{"key":"key\n\t\t\t\t20180912081316_gay035C29","doi-asserted-by":"crossref","first-page":"e90359","DOI":"10.1371\/journal.pone.0090359","article-title":"GnRH Agonist vs. hCG for triggering of ovulation\u2014differential effects on gene expression in human granulosa cells","volume":"9","author":"Haas","year":"2014","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t20180912081316_gay035C30","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1016\/S1472-6483(10)61028-0","article-title":"Comparative protein expression profiling in human cumulus cells in relation to oocyte fertilization and ovarian stimulation protocol","volume":"13","author":"Hamamah","year":"2006","journal-title":"Reprod Biomed Online"},{"key":"key\n\t\t\t\t20180912081316_gay035C31","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1093\/humrep\/der414","article-title":"When and how should new technology be introduced into the IVF laboratory?","volume":"27","author":"Harper","year":"2012","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20180912081316_gay035C32","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1139\/Y10-009","article-title":"Bidirectional communication between oocytes and follicle cells: ensuring oocyte developmental competence","volume":"88","author":"Kidder","year":"2010","journal-title":"Can J Physiol Pharmacol"},{"key":"key\n\t\t\t\t20180912081316_gay035C33","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3803\/EnM.2014.29.1.40","article-title":"Correlation between expression of glucose transporters in granulosa cells and oocyte quality in women with polycystic ovary syndrome","volume":"29","author":"Kim","year":"2014","journal-title":"Endocrinol Metab"},{"key":"key\n\t\t\t\t20180912081316_gay035C34","doi-asserted-by":"crossref","first-page":"R69","DOI":"10.1530\/REP-16-0500","article-title":"Granulosa cell biomarkers to predict pregnancy in ART: pieces to solve the puzzle","volume":"153","author":"Kordus","year":"2017","journal-title":"Reproduction"},{"key":"key\n\t\t\t\t20180912081316_gay035C35","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0091-679X(08)00610-9","article-title":"Infrared and Raman microscopy in cell biology","volume":"89","author":"Matth\u00e4us","year":"2008","journal-title":"Methods Cell Biol"},{"key":"key\n\t\t\t\t20180912081316_gay035C36","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1080\/05704920701829043","article-title":"Fourier transform infrared (FTIR) spectroscopy of biological tissues","volume":"43","author":"Movasaghi","year":"2008","journal-title":"Appl Spectrosc Rev"},{"key":"key\n\t\t\t\t20180912081316_gay035C37","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1016\/j.fertnstert.2008.01.003","article-title":"From oocyte to baby: a clinical evaluation of the biological efficiency of in vitro fertilization","volume":"91","author":"Patrizio","year":"2009","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20180912081316_gay035C38","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s10815-013-9943-y","article-title":"New molecular markers for the evaluation of gamete quality","volume":"30","author":"Ruvolo","year":"2013","journal-title":"J Assist Reprod Genet"},{"key":"key\n\t\t\t\t20180912081316_gay035C4000","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.vibspec.2013.07.002","article-title":"Infrared microspectroscopy of oral squamous cell carcinoma: spectral signatures of cancer grading","volume":"68","author":"Sabbatini","year":"2013","journal-title":"Vib Spectrosc"},{"key":"key\n\t\t\t\t20180912081316_gay035C39","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.reprotox.2013.05.008","article-title":"The cigarette smoke constituent benzo[a]pyrene disrupts metabolic enzyme, and apoptosis pathway member gene expression in ovarian follicles","volume":"40","author":"Sadeu","year":"2013","journal-title":"Reprod Toxicol"},{"key":"key\n\t\t\t\t20180912081316_gay035C40","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1093\/humrep\/12.6.1267","article-title":"Oocyte morphology predicts outcome of intracytoplasmic sperm injection","volume":"12","author":"Serhal","year":"1997","journal-title":"Hum Reprod"},{"key":"key\n\t\t\t\t20180912081316_gay035C41","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1023\/A:1012719316332","article-title":"The ovarian life cycle: a contemporary view","volume":"3","author":"Suh","year":"2002","journal-title":"Rev Endocr Metab Disord"},{"key":"key\n\t\t\t\t20180912081316_gay035C42","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/mrd.22340","article-title":"Assisted reproductive technology results: why are live-birth percentages so low?","volume":"81","author":"Tar\u00edn","year":"2014","journal-title":"Mol Reprod Dev"},{"key":"key\n\t\t\t\t20180912081316_gay035C43","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.fertnstert.2012.11.029","article-title":"The aging ovary\u2014the poor granulosa cells","volume":"99","author":"Tatone","year":"2013","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20180912081316_gay035C5000","doi-asserted-by":"crossref","first-page":"3213","DOI":"10.1039\/c0an00505c","article-title":"FTIR microspectroscopy of melanocytic skin lesions: a preliminary study","volume":"135","author":"Tosi","year":"2010","journal-title":"Analyst"},{"key":"key\n\t\t\t\t20180912081316_gay035C44","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.fertnstert.2013.01.129","article-title":"Cumulus and granulosa cell markers of oocyte and embryo quality","volume":"99","author":"Uyar","year":"2013","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t20180912081316_gay035C45","doi-asserted-by":"crossref","DOI":"10.3109\/9780203008935","volume-title":"An Atlas of Human Blastocyst. Parthenon Publ Gr","author":"Veeck","year":"2003"},{"key":"key\n\t\t\t\t20180912081316_gay035C46","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.rbmo.2011.08.015","article-title":"Non-invasive viability assessment of day-4 frozen\u2013thawed human embryos using near infrared spectroscopy","volume":"23","author":"Vergouw","year":"2011","journal-title":"Reprod Biomed Online"},{"key":"key\n\t\t\t\t20180912081316_gay035C47","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1155\/2010\/576151","article-title":"In situ FTIR studies on mammalian cells","volume":"24","author":"Wolkers","year":"2010","journal-title":"Spectroscopy"}],"container-title":["MHR: Basic science of reproductive medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/molehr\/advance-article-pdf\/doi\/10.1093\/molehr\/gay035\/25720171\/gay035.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,7]],"date-time":"2020-11-07T16:37:47Z","timestamp":1604767067000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/molehr\/advance-article\/doi\/10.1093\/molehr\/gay035\/5073125"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,12]]},"references-count":53,"URL":"https:\/\/doi.org\/10.1093\/molehr\/gay035","relation":{},"ISSN":["1460-2407"],"issn-type":[{"value":"1460-2407","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,12]]}}}