{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:43:02Z","timestamp":1775306582101,"version":"3.50.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T00:00:00Z","timestamp":1534982400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Funda\u00e7\u00e3o de Amparo a Pesquisa do Estado de S\u00e3o Paulo","award":["# 2008\/58835-2"],"award-info":[{"award-number":["# 2008\/58835-2"]}]},{"name":"Conselho Nacional de Pesquisa","award":["# 485032\/2007-4"],"award-info":[{"award-number":["# 485032\/2007-4"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2018,11,1]]},"DOI":"10.1093\/molehr\/gay037","type":"journal-article","created":{"date-parts":[[2018,8,22]],"date-time":"2018-08-22T19:17:32Z","timestamp":1534965452000},"page":"556-563","source":"Crossref","is-referenced-by-count":15,"title":["MicroRNAs involved in the<i>HMGA2<\/i>deregulation and its co-occurrence with<i>MED12<\/i>mutation in uterine leiomyoma"],"prefix":"10.1093","volume":"24","author":[{"given":"J B H","family":"Mello","sequence":"first","affiliation":[{"name":"CIPE-International Research Center\u2014AC Camargo Cancer Center, Sao Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M C","family":"Barros-Filho","sequence":"additional","affiliation":[{"name":"CIPE-International Research Center\u2014AC Camargo Cancer Center, Sao Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F B","family":"Abreu","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P D R","family":"Cirilo","sequence":"additional","affiliation":[{"name":"Hermes Pardini Institute, Research & Development Department, Belo Horizonte, MG, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M A C","family":"Domingues","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine, University of Sao Paulo State\u2014UNESP, Botucatu-SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Pontes","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, School of Medicine, University of Sao Paulo State\u2014UNESP, Botucatu-SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4637-5687","authenticated-orcid":false,"given":"S R","family":"Rogatto","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Vejle Hospital, Institute of Regional Health Research, University of Southern Denmark, DK, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2018,8,23]]},"reference":[{"key":"key\n\t\t\t\t2018103007504430100_gay037C1","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1210\/jc.2015-3555","article-title":"Vitamin D3 inhibits Wnt\/\u03b2-catenin and mTOR signaling pathways in human uterine fibroid cells","volume":"101","author":"Al-Hendy","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C2","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1067\/mob.2003.99","article-title":"High cumulative incidence of uterine leiomyoma in black and white women: ultrasound evidence","volume":"188","author":"Baird","year":"2003","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C3","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3389\/fgene.2017.00031","article-title":"The LIN28\/let-7 pathway in cancer","volume":"8","author":"Balzeau","year":"2017","journal-title":"Front Genet"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C4","author":"Belchior","year":"2011"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C5","doi-asserted-by":"crossref","first-page":"1144","DOI":"10.1038\/modpathol.2013.243","article-title":"MED12 and HMGA2 mutations: two independent genetic events in uterine leiomyoma and leiomyosarcoma","volume":"27","author":"Bertsch","year":"2014","journal-title":"Mod Pathol"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C6","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.1016\/j.ajog.2005.02.097","article-title":"Independent clonal origin of multiple uterine leiomyomas that was determined by X chromosome inactivation and microsatellite analysis","volume":"193","author":"Canevari","year":"2005","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C7","doi-asserted-by":"crossref","first-page":"e211","DOI":"10.1016\/j.ajog.2011.12.002","article-title":"The estimated annual cost of uterine leiomyomata in the United States","volume":"206","author":"Cardozo","year":"2012","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C8","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1210\/me.2012-1075","article-title":"miR-93\/106b and their host gene, MCM7, are differentially expressed in leiomyomas and functionally target F3 and IL-8","volume":"26","author":"Chuang","year":"2012","journal-title":"Mol Endocrinol"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C9","doi-asserted-by":"crossref","first-page":"e57901","DOI":"10.1371\/journal.pone.0057901","article-title":"An integrative genomic and transcriptomic analysis reveals potential targets associated with cell proliferation in uterine leiomyomas","volume":"8","author":"Cirilo","year":"2013","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C500"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C10","doi-asserted-by":"crossref","first-page":"759","DOI":"10.4161\/cc.7.6.5834","article-title":"The let-7 microRNA reduces tumor growth in mouse models of lung cancer","volume":"7","author":"Esquela-Kerscher","year":"2008","journal-title":"Cell Cycle"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C11","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1289\/ehp.5787","article-title":"Etiology and pathogenesis of uterine leiomyomas: a review","volume":"111","author":"Flake","year":"2003","journal-title":"Environ Health Perspect"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C12","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.ygeno.2012.03.003","article-title":"Characterization of the uterine leiomyoma microRNAome by deep sequencing","volume":"99","author":"Georgieva","year":"2012","journal-title":"Genomics"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C13","doi-asserted-by":"crossref","first-page":"28226","DOI":"10.18632\/oncotarget.15999","article-title":"MiR-let-7a inhibits cell proliferation, migration, and invasion by down-regulating PKM2 in cervical cancer","volume":"8","author":"Guo","year":"2017","journal-title":"Oncotarget"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C14","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1093\/humupd\/dmu017","article-title":"MicroRNAs in the development and pathobiology of uterine leiomyomata: does evidence support future strategies for clinical intervention?","volume":"20","author":"Karmon","year":"2014","journal-title":"Hum Reprod Update"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C15","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.cancergencyto.2009.09.021","article-title":"Loss of let-7 binding sites resulting from truncations of the 3\u2019 untranslated region of HMGA2 mRNA in uterine leiomyomas","volume":"196","author":"Klemke","year":"2010","journal-title":"Cancer Genet Cytogenet"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C16","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/gcc.20627","article-title":"Overexpression of HMGA2 in uterine leiomyomas points to its general role for the pathogenesis of the disease","volume":"48","author":"Klemke","year":"2009","journal-title":"Genes Chromosomes Cancer"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C17","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1261\/rna.051177.115","article-title":"Systematic analysis of the Hmga2 3\u2032 UTR identifies many independent regulatory sequences and a novel interaction between distal sites","volume":"21","author":"Kristjansdottir","year":"2015","journal-title":"RNA"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C18","doi-asserted-by":"crossref","first-page":"124","DOI":"10.7150\/ijms.21856","article-title":"Analysis of MED12 Mutation in Multiple Uterine Leiomyomas in South Korean patients","volume":"15","author":"Lee","year":"2018","journal-title":"Int J Med Sci"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C20","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1111\/his.12401","article-title":"HMGA2 is down-regulated by microRNA let-7 and associated with epithelial-mesenchymal transition in esophageal squamous cell carcinomas of Kazakhs","volume":"65","author":"Liu","year":"2014","journal-title":"Histopathology"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C21","doi-asserted-by":"crossref","first-page":"9163","DOI":"10.1007\/s13277-014-2185-5","article-title":"H19 promotes pancreatic cancer metastasis by derepressing let-7\u2019s suppression on its target HMGA2-mediated EMT","volume":"35","author":"Ma","year":"2014","journal-title":"Tumour Biol"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C22","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1186\/s12943-017-0672-1","article-title":"Characterization of MED12, HMGA2, and FH alterations reveals molecular variability in uterine smooth muscle tumors","volume":"16","author":"Makinen","year":"2017","journal-title":"Mol Cancer"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C23","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1126\/science.1208930","article-title":"MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas","volume":"334","author":"Makinen","year":"2011","journal-title":"Science"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C24","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1002\/ijc.27424","article-title":"L\u20aconing T, Drieschner N, Helmke BM, Bullerdiek J. MED12 mutations in uterine fibroids - their relationship to cytogenetic subgroups","volume":"131","author":"Markowski","year":"2012","journal-title":"Int J Cancer"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C25","doi-asserted-by":"crossref","first-page":"1576","DOI":"10.1126\/science.1137999","article-title":"Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation","volume":"315","author":"Mayr","year":"2007","journal-title":"Science"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C26","doi-asserted-by":"crossref","first-page":"e33251","DOI":"10.1371\/journal.pone.0033251","article-title":"Whole exome sequencing in a random sample of North American women with leiomyomas identifies MED12 mutations in majority of uterine leiomyomas","volume":"7","author":"McGuire","year":"2012","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C27","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1073\/pnas.1518752113","article-title":"Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers","volume":"113","author":"Mehine","year":"2016","journal-title":"Proc Natl Acad Sci"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C28","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1056\/NEJMoa1302736","article-title":"Characterization of uterine leiomyomas by whole-genome sequencing","volume":"369","author":"Mehine","year":"2013","journal-title":"N Engl J Med"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C29","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.fertnstert.2014.06.050","article-title":"Genomics of uterine leiomyomas: insights from high-throughput sequencing","volume":"102","author":"Mehine","year":"2014","journal-title":"Fertil Steril"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C30","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/S0002-9378(16)33500-1","article-title":"Dating the endometrial biopsy","volume":"122","author":"Noyes","year":"1975","journal-title":"Am J Obstet Gynecol"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C32","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1158\/1541-7786.MCR-07-0370","article-title":"Antiproliferative effects by Let-7 repression of high-mobility group A2 in uterine leiomyoma","volume":"6","author":"Peng","year":"2008","journal-title":"Mol Cancer Res"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C33","doi-asserted-by":"crossref","first-page":"e45","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C34","first-page":"1351","article-title":"Fusion transcripts involving HMGA2 are not a common molecular mechanism in uterine leiomyomata with rearrangements in 12q15","volume":"63","author":"Quade","year":"2003","journal-title":"Cancer Res"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C36","doi-asserted-by":"crossref","first-page":"2396","DOI":"10.1080\/15384101.2017.1387699","article-title":"Arsenic trioxide inhibits cell growth and motility via up-regulation of let-7a in breast cancer cells","volume":"16","author":"Shi","year":"2017","journal-title":"Cell Cycle"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C37","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.bpobgyn.2015.11.018","article-title":"The epidemiology and genetics of uterine leiomyoma","volume":"34","author":"Styer","year":"2016","journal-title":"Best Pract Res Clin Obstet Gynaecol"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C38","doi-asserted-by":"crossref","first-page":"research0034.1","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C39","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1089\/cbr.2012.1307","article-title":"MicroRNA let-7a inhibits the proliferation and invasion of nonsmall cell lung cancer cell line 95D by regulating K-Ras and HMGA2 gene expression","volume":"28","author":"Wang","year":"2013","journal-title":"Cancer Biother Radiopharm"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C40","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/gcc.20415","article-title":"A micro-RNA signature associated with race, tumor size, and target gene activity in human uterine leiomyomas","volume":"46","author":"Wang","year":"2007","journal-title":"Genes Chromosomes Cancer"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.biopha.2015.02.004","article-title":"Effects of miRNA-197 overexpression on proliferation, apoptosis and migration in levonorgestrel treated uterine leiomyoma cells","volume":"71","author":"Wu","year":"2015","journal-title":"Biomed Pharmacother"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C42","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1186\/s12967-015-0462-8","article-title":"Let-7a inhibits migration, invasion and epithelial-mesenchymal transition by targeting HMGA2 in nasopharyngeal carcinoma","volume":"13","author":"Wu","year":"2015","journal-title":"J Transl Med"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C43","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1080\/15384047.2015.1095405","article-title":"Decreased microRNA-26a expression causes cisplatin resistance in human non-small cell lung cancer","volume":"17","author":"Yang","year":"2016","journal-title":"Cancer Biol Ther"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C44","doi-asserted-by":"crossref","first-page":"e12362","DOI":"10.1371\/journal.pone.0012362","article-title":"Profiling and functional analyses of microRNAs and their target gene products in human uterine leiomyomas","volume":"5","author":"Zavadil","year":"2010","journal-title":"PLoS One"},{"key":"key\n\t\t\t\t2018103007504430100_gay037C45","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.3892\/ijo.2014.2360","article-title":"MicroRNA-26a acts as a tumor suppressor inhibiting gallbladder cancer cell proliferation by directly targeting HMGA2","volume":"44","author":"Zhou","year":"2014","journal-title":"Int J Oncol"}],"container-title":["MHR: Basic science of reproductive medicine"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/molehr\/article-pdf\/24\/11\/556\/26194874\/gay037.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,8]],"date-time":"2020-11-08T03:49:19Z","timestamp":1604807359000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/molehr\/article\/24\/11\/556\/5078567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8,23]]},"references-count":43,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,8,23]]},"published-print":{"date-parts":[[2018,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/molehr\/gay037","relation":{},"ISSN":["1460-2407"],"issn-type":[{"value":"1460-2407","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2018,11]]},"published":{"date-parts":[[2018,8,23]]}}}