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Here we have examined whether TNFRp55 deficiency modulates the pro-inflammatory state and the reinnervation of endometriotic-like lesions in mice. Two-month-old female C57BL\/6 mice, eight wild type (WT) and eight TNFRp55\u2212\/\u2212 (KO) were used in the study. Endometriotic-like lesions were induced experimentally. The right uterine horn was removed from the animal, divided longitudinally, cut in three square pieces and sutured to the intestine mesentery. After 4\u00a0weeks, the lesions and the peritoneal fluid were collected. The level of TNF\u03b1 in the peritoneal fluid was evaluated by enzyme-linked immunosorbent assay (EIA). The expressions of COX2, GR\u03b1 and GR\u03b2 were evaluated in the lesions by western blot and immunohistochemistry. \u03b2-III TUBULIN, BDNF and NGF protein concentrations were evaluated in the lesions by western blot. Gene expression of Pgp 9.5, SP and Th was analyzed by RT-PCR, whereas relative concentrations of TRKA, NTRp75, phosphorylated NF\u03baB (pNF\u03baB) and total NF\u03baB in lesions were measured by EIA. Compared with the WT group, the KO mice showed lower TNF\u03b1 levels in the peritoneal fluid and lower numbers of COX2 immunoreactive cells along with increased expression of GR\u03b1, \u03b2-III TUBULIN, Pgp 9.5, SP, Th, BDNF, NGF, NTRp75 and pNF\u03baB in the lesions. Future histological studies will be necessary to confirm the sensory\/sympathetic imbalance in the endometriotic-like lesions of the KO mice. Our results suggest that a reduced inflammatory state promotes reinnervation of endometriotic-like lesions in TNFRp55\u2212\/\u2212 mice. Chronic deregulation of TNF receptors can have serious consequences for women with advanced endometriosis.<\/jats:p>","DOI":"10.1093\/molehr\/gaz026","type":"journal-article","created":{"date-parts":[[2019,5,3]],"date-time":"2019-05-03T19:12:29Z","timestamp":1556910749000},"page":"385-396","source":"Crossref","is-referenced-by-count":6,"title":["Reduced inflammatory state promotes reinnervation of endometriotic-like lesions in TNFRp55 deficient mice"],"prefix":"10.1093","volume":"25","author":[{"given":"F","family":"Ghersa","sequence":"first","affiliation":[{"name":"Laboratorio de Biolog\u00eda de la Reproducci\u00f3n (LABIR), Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis. Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas de San Luis (IMIBIO-SL-CONICET), Ej\u00e9rcito de Los Andes 950, CP D5700HHW, San Luis, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M B","family":"Delsouc","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda de la Reproducci\u00f3n (LABIR), Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis. Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas de San Luis (IMIBIO-SL-CONICET), Ej\u00e9rcito de Los Andes 950, CP D5700HHW, San Luis, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A A","family":"Goyeneche","sequence":"additional","affiliation":[{"name":"Experimental Pathology Unit, Department of Pathology, Faculty of Medicine, McGill University, 3775 University Street, Montreal, QC H3A 2B4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S S","family":"Vallcaneras","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda de la Reproducci\u00f3n (LABIR), Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis. Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas de San Luis (IMIBIO-SL-CONICET), Ej\u00e9rcito de Los Andes 950, CP D5700HHW, San Luis, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Meresman","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiopatolog\u00eda Endometrial, Instituto de Biolog\u00eda y Medicina Experimental (IBYME-CONICET), Vuelta de Obligado 2490, CP C1428ADN, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C M","family":"Telleria","sequence":"additional","affiliation":[{"name":"Experimental Pathology Unit, Department of Pathology, Faculty of Medicine, McGill University, 3775 University Street, Montreal, QC H3A 2B4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4334-5845","authenticated-orcid":false,"given":"M","family":"Casais","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda de la Reproducci\u00f3n (LABIR), Facultad de Qu\u00edmica, Bioqu\u00edmica y Farmacia, Universidad Nacional de San Luis. Instituto Multidisciplinario de Investigaciones Biol\u00f3gicas de San Luis (IMIBIO-SL-CONICET), Ej\u00e9rcito de Los Andes 950, CP D5700HHW, San Luis, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,5,9]]},"reference":[{"key":"2019071213254906900_ref1","doi-asserted-by":"crossref","first-page":"578.e1","DOI":"10.1016\/j.ajog.2007.04.032","article-title":"A pilot study to evaluate the relative efficacy of endometrial biopsy and full curettage in making a diagnosis of endometriosis by the detection of endometrial nerve fibers","volume":"197","author":"Al-Jefout","year":"2007","journal-title":"Am J Obstet Gynecol"},{"key":"2019071213254906900_ref2","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.bbi.2011.08.004","article-title":"Imbalance between sympathetic and sensory innervation in peritoneal endometriosis","volume":"26","author":"Arnold","year":"2012","journal-title":"Brain Behav 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