{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T04:16:06Z","timestamp":1769141766148,"version":"3.49.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"SERB-SURE","award":["SUR\/2022\/005355"],"award-info":[{"award-number":["SUR\/2022\/005355"]}]},{"name":"SERB, Government of India"},{"name":"Savitribai Phule Pune University RUSA-2.0","award":["CBS-TH4.4"],"award-info":[{"award-number":["CBS-TH4.4"]}]},{"name":"CSIR, Government of India","award":["Aspire (37WS(0111)\/2023-24\/EMR-II\/ASPIRE)"],"award-info":[{"award-number":["Aspire (37WS(0111)\/2023-24\/EMR-II\/ASPIRE)"]}]},{"name":"SARTHI research fellowship-CSMNRF-2021, GOM, India"},{"name":"CSIR-JRF and SRF"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Breast cancer subtypes exhibit significant molecular and metabolic heterogeneity, influencing their aggressiveness and therapeutic responses. Among them, triple-negative breast cancer (TNBC) is highly aggressive and often resistant to conventional therapies. To investigate the metabolic programming of this aggressiveness, we conducted an integrated transcriptomics and metabolomics analysis comparing the MCF-7 (luminal A, ER+\/PR+) and MDA-MB-231 (TNBC) breast cancer cell lines. Transcriptome analysis of MCF-7 and MDA-MB-231 revealed the differential expression of genes involved in key metabolic pathways. Metabolomics data, further corroborated by transcriptomics, suggest pathway enrichment in beta-alanine, histidine, glutathione, nucleotide metabolism, and the tricarboxylic acid cycle. MDA-MB-231 cells displayed a metabolically aggressive phenotype with enhanced oxidative phosphorylation, redox adaptation, and nucleotide turnover. In contrast, MCF-7 cells showed a more regulated amino acid and redox metabolism profile. The integration of transcriptomic and metabolite profiles highlighted potential metabolic vulnerabilities in TNBC, offering insights into subtype-specific differences at the molecular level.<\/jats:p>","DOI":"10.1093\/momics\/aaiaf003","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T09:01:17Z","timestamp":1767776477000},"source":"Crossref","is-referenced-by-count":0,"title":["Integrative transcriptomics and metabolomics reveal distinct metabolic reprogramming in luminal and triple-negative breast cancer cells"],"prefix":"10.1093","volume":"22","author":[{"given":"Preeti","family":"Ranawade","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Savitribai Phule Pune University , Pune 411007 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Babasaheb","family":"Sonwane","sequence":"additional","affiliation":[{"name":"Biochemical Science Division, CSIR-National Chemical Laboratory , Pune 411008 ,","place":["India"]},{"name":"Academy of Scientific and Innovative Research (AcSIR) , Ghaziabad 201002 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganesh","family":"Bose","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Savitribai Phule Pune University , Pune 411007 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Revati","family":"Jadhav","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Savitribai Phule Pune University , Pune 411007 ,","place":["India"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8016-1178","authenticated-orcid":false,"given":"Rakesh","family":"Joshi","sequence":"additional","affiliation":[{"name":"Biochemical Science Division, CSIR-National Chemical Laboratory , Pune 411008 ,","place":["India"]},{"name":"Academy of Scientific and Innovative Research (AcSIR) , Ghaziabad 201002 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