{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T21:34:07Z","timestamp":1769549647013,"version":"3.49.0"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,28]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Interstitial lung disease (ILD) associated with the antimelanoma differentiation-associated protein 5 (anti-MDA5) antibody is a rapidly progressive disease that requires timely, aggressive treatment. However, prompt diagnosis is difficult due to the longer time required for antibody detection. This study described the computed tomography (CT) findings of anti-MDA5 antibody-positive ILD (anti-MDA5-ILD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>CT findings of 20 patients (7 men, 13 women; mean age, 53.6\u2009\u00b1\u200913.5\u2009years) with anti-MDA5-ILD were retrospectively reviewed. All patients had clinical diagnoses of dermatomyositis, and 14 patients presented with amyopathic findings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Bilateral ground-glass attenuation, air-space consolidation, and reticular shadows were observed in 20 (100%), 15 (75%), and 3 (15%) patients, respectively. The spread of air-space consolidation was 6.0\u2009\u00b1\u20095.6% (mean\u2009\u00b1\u2009standard deviation). Univariate analysis revealed that high Krebs von den Lungen-6, high spread of consolidation, low partial pressure of oxygen, and low forced vital capacity were significant predictors for poor survival. The final radiological diagnoses were nonspecific interstitial pneumonia and organising pneumonia (OP) in 2 (10%) and 16 (80%) patients, respectively. Further, 30% of OP patients showed fibrosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The characteristic CT findings of patients with anti-MDA5-ILD were ground-glass attenuation, air-space consolidation, and less reticulation. These CT findings were compatible with those of OP.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roab006","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T13:46:35Z","timestamp":1639575995000},"page":"365-372","source":"Crossref","is-referenced-by-count":8,"title":["Chest computed tomography findings of adult patients with antimelanoma differentiation-associated protein 5 antibody-positive interstitial lung disease"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7120-8517","authenticated-orcid":false,"given":"Yuko","family":"Waseda","sequence":"first","affiliation":[{"name":"Third Department of Internal Medicine, Faculty of Medical Sciences, University of Fukui, Fukui, Japan"},{"name":"Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria"},{"name":"Department of Respiratory Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takeshi","family":"Johkoh","sequence":"additional","affiliation":[{"name":"Department of Radiology, Kansai Rosai Hospital, Hyogo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helmut","family":"Prosch","sequence":"additional","affiliation":[{"name":"Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Nemec","sequence":"additional","affiliation":[{"name":"Department of Biomedical Imaging and Image-guided Therapy, Medical University of Vienna, Vienna, Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keigo","family":"Saeki","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Kanazawa University Graduate School of Medical Science, Ishikawa, 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