{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:38:12Z","timestamp":1767008292353,"version":"3.37.3"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,9,4]],"date-time":"2021-09-04T00:00:00Z","timestamp":1630713600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,18]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Microscopic polyangiitis (MPA) affects various organs. However, echocardiographic findings of MPA are unclear. We aimed to evaluate the echocardiographic features of acute-phase MPA in Japanese patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This single-centre retrospective study included 15 patients with MPA who underwent echocardiography within 2\u2009weeks of commencing steroid therapy for induction or reinduction. The echocardiography parameters of thetients were compared with those of 30 age- and sex-matched controls.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>No significant differences in left ventricular (LV) diameter, LV ejection fraction, or e\u2019 were observed between the two groups. However, the MPA group showed a significantly higher left atrial (LA) diameter and LA volume index, as well as higher early diastolic filling velocity, diastolic pulmonary venous flow velocity, and trans-tricuspid pressure gradient, and a shorter deceleration time (DCT). Serum C-reactive protein levels were positively correlated with E wave, E\/A, and DCT. These results may indicate that increased LV stiffness, rather than impairment of LV relaxation, contributed to LV diastolic function, resulting in LA enlargement.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Patients with acute-phase MPA had LA dilatation associated with LV diastolic dysfunction. This finding indicates the importance of cardiac assessment in patients with MPA, especially in patients with a strong inflammatory reaction.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roab028","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T11:09:14Z","timestamp":1639393754000},"page":"606-612","source":"Crossref","is-referenced-by-count":1,"title":["Echocardiographic features of acute-phase microscopic polyangiitis in Japanese patients: A single-centre retrospective study"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0128-3463","authenticated-orcid":false,"given":"Takashi","family":"Nawata","sequence":"first","affiliation":[{"name":"Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natsu","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinichi","family":"Okuda","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makoto","family":"Kubo","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuaki","family":"Wada","sequence":"additional","affiliation":[{"name":"Division of Clinical Laboratory, Yamaguchi University Hospital, Ube, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeki","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuaki","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory Sciences, Yamaguchi University Graduate School of Medicine, Ube, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masafumi","family":"Yano","sequence":"additional","affiliation":[{"name":"Department of Medicine and Clinical Science, Yamaguchi University Graduate School of Medicine, Ube, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,9,4]]},"reference":[{"key":"2022042010022928900_R1","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1136\/annrheumdis-2016-209133","article-title":"EULAR\/ERA-EDTA recommendations for the management of ANCA-associated vasculitis","volume":"75","author":"Yates","year":"2016","journal-title":"Ann Rheum 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