{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:28:54Z","timestamp":1787009334515,"version":"build-2736575974"},"reference-count":20,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2101000367"],"award-info":[{"award-number":["2101000367"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007937","name":"Peking University","doi-asserted-by":"publisher","award":["800673, 800696, and 2198000115"],"award-info":[{"award-number":["800673, 800696, and 2198000115"]}],"id":[{"id":"10.13039\/501100007937","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Technology Major Projects of Beijing Municipal Science and Technology Commission of China","award":["2144000062, 2150000001, 2144000045, and 2144000039"],"award-info":[{"award-number":["2144000062, 2150000001, 2144000045, and 2144000039"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,4,18]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>The global trend of research on hyperuricaemia (HUA) has not been well studied. Therefore, this study aimed to investigate the trend of research on HUA and compare the findings in publications from different countries, institutions, journals, and authors, to predict the research hotspots.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Publications related to HUA were searched using the Science Citation Index-Expanded Web of Science. The data were analysed by using the bibliometric methodology. Additionally, a graphical mapping was generated by using the VOS viewer software to carry out a co-occurrence analysis and to investigate the trend of publications in this field.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 6313 articles were included. The number of publications was increasing globally yearly. USA was the leading country in global research in this field, with the largest number of publications and citations as well as the highest H-index (H-index reflects both the number of publications and the number of citations per publication). PLOS One published the largest number of publications related to HUA. JOHNSON RJ T has published the largest number of papers in this field. Published studies could be classified into six clusters: \u2018Pathophysiology\u2019, \u2018HUA and metabolic syndrome\u2019, \u2018HUA and cardiovascular disease\u2019, \u2018HUA and gout\u2019, \u2018HUA and nephropathy\u2019, and \u2018Genome-wide research\u2019. \u2018Pathophysiology\u2019, \u2018HUA and cardiovascular disease\u2019, \u2018HUA and gout\u2019, and \u2018Genome-wide research\u2019 were predicted as the next hot topics in HUA research.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>USA was the leading country in global research in this field. It is expected that an increasing research output will continue to be observed in the near future. \u2018Pathophysiology\u2019, \u2018HUA and cardiovascular disease\u2019, \u2018HUA and gout\u2019, and \u2018Genome-wide research\u2019 may be the next hotspots and hence need more attention in the future.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/mr\/roab031","type":"journal-article","created":{"date-parts":[[2021,12,13]],"date-time":"2021-12-13T06:09:33Z","timestamp":1639375773000},"page":"619-625","source":"Crossref","is-referenced-by-count":10,"title":["Global research trends in hyperuricemia: a bibliometric and visualized study"],"prefix":"10.1093","volume":"32","author":[{"given":"Qingxi","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Orthopedic Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Arthritis Clinic and Research Center, Peking University People\u2019s Hospital, Peking University, Beijing, China"},{"name":"Arthritis Institute, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Xing","sequence":"additional","affiliation":[{"name":"Arthritis Clinic and Research Center, Peking University People\u2019s Hospital, Peking University, Beijing, China"},{"name":"Arthritis Institute, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhao","family":"Lin","sequence":"additional","affiliation":[{"name":"Arthritis Clinic and Research Center, Peking University People\u2019s Hospital, Peking University, Beijing, China"},{"name":"Arthritis Institute, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"key":"2022042010023955100_R1","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s10741-019-09869-z","article-title":"Hyperuricemia: a novel old disorder-relationship and potential mechanisms in heart failure","volume":"25","author":"Borghi","year":"2020","journal-title":"Heart Fail Rev"},{"key":"2022042010023955100_R2","doi-asserted-by":"publisher","first-page":"3047","DOI":"10.3892\/etm.2017.4345","article-title":"Protective role of \u03b1-lipoic acid in hyperuricemia- induced endothelial dysfunction","volume":"13","author":"Zou","year":"2017","journal-title":"Exp Ther Med"},{"key":"2022042010023955100_R3","doi-asserted-by":"publisher","first-page":"3136","DOI":"10.1002\/art.30520","article-title":"Prevalence of gout and hyperuricemia in the US general population: the National health and nutrition examination survey 2007\u20132008","volume":"63","author":"Zhu","year":"2011","journal-title":"Arthritis Rheum"},{"key":"2022042010023955100_R4","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/0021-9681(72)90166-x","article-title":"Serum uric acid in 23,923 men and gout in a subsample of 4257 men in France","volume":"25","author":"Zalokar","year":"1972","journal-title":"J Chronic Dis"},{"key":"2022042010023955100_R5","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1016\/j.jbspin.2018.10.004","article-title":"How should we manage asymptomatic hyperuricemia?","volume":"86","author":"Chal\u00e8s","year":"2019","journal-title":"Joint Bone Spine"},{"key":"2022042010023955100_R6","doi-asserted-by":"publisher","first-page":"1847","DOI":"10.1002\/art.40572","article-title":"Monosodium urate crystal deposits are common in asymptomatic sons of people with gout: the sons of gout study","volume":"70","author":"Abhishek","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"2022042010023955100_R7","doi-asserted-by":"publisher","first-page":"855","DOI":"10.3346\/jkms.2013.28.6.855","article-title":"The association between uric acid and chronic kidney disease in Korean men: a 4-year follow-up study","volume":"28","author":"Ryoo","year":"2013","journal-title":"J Korean Med Sci"},{"key":"2022042010023955100_R8","doi-asserted-by":"publisher","first-page":"574","DOI":"10.3899\/jrheum.170806","article-title":"The rising incidence of gout and the increasing burden of comorbidities: a population-based study over 20 years","volume":"45","author":"Elfishawi","year":"2018","journal-title":"J Rheumatol"},{"key":"2022042010023955100_R9","doi-asserted-by":"publisher","first-page":"92","DOI":"10.1111\/imr.12833","article-title":"Urate-induced immune programming: consequences for gouty arthritis and hyperuricemia","volume":"294","author":"Cab\u0103u","year":"2020","journal-title":"Immunol Rev"},{"key":"2022042010023955100_R10","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2016-011623","article-title":"Bibliometric analysis of scientific publications in transplantation journals from Mainland China, Japan, South Korea and Taiwan between 2006 and 2015","volume":"6","author":"QiangHong","year":"2016","journal-title":"BMJ Open"},{"key":"2022042010023955100_R11","doi-asserted-by":"publisher","first-page":"1806","DOI":"10.1007\/s00586-015-4030-y","article-title":"Growing trend of China\u2019s contribution to the field of spine: a 10-year survey of the literature","volume":"24","author":"Jia","year":"2015","journal-title":"Eur Spine J"},{"key":"2022042010023955100_R12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0184869","article-title":"Publication trends of research on diabetes mellitus and T cells (1997\u20132016): a 20-year bibliometric study","volume":"12","author":"Gao","year":"2017","journal-title":"PLoS One"},{"key":"2022042010023955100_R13","doi-asserted-by":"publisher","first-page":"1040","DOI":"10.1016\/j.jtho.2016.03.010","article-title":"The state of lung cancer research: a global analysis","volume":"11","author":"Aggarwal","year":"2016","journal-title":"J Thorac Oncol"},{"key":"2022042010023955100_R14","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1038\/embor.2008.233","article-title":"The state of H index research. Is the H index the ideal way to measure research performance","volume":"10","author":"Bornmann","year":"2008","journal-title":"EMBO Rep"},{"key":"2022042010023955100_R15","article-title":"A systematic literature review of green and sustainable logistics: bibliometric analysis, research trend and knowledge taxonomy","volume":"17","author":"Ren","year":"2020","journal-title":"Int J Environ Res Public Health"},{"key":"2022042010023955100_R16","doi-asserted-by":"crossref","first-page":"27","DOI":"10.7150\/ijbs.37496","article-title":"Publication trends of research on sepsis and host immune response during 1999\u20132019: A 20-year bibliometric analysis","volume":"16","author":"Yao","year":"2020","journal-title":"Int J Biol Sci"},{"key":"2022042010023955100_R17","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-1018-7","article-title":"Stem cell therapy for treating osteonecrosis of the femoral head: from clinical applications to related basic research","volume":"9","author":"Li","year":"2018","journal-title":"Stem Cell Res Ther"},{"key":"2022042010023955100_R18","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0062395","article-title":"Citation analysis may severely underestimate the impact of clinical research as compared to basic research","volume":"8","author":"van Eck","year":"2013","journal-title":"PLoS One"},{"key":"2022042010023955100_R19","first-page":"2749","article-title":"Roles of hyperuricemia in metabolic syndrome and cardiac-kidney-vascular system diseases","volume":"10","author":"Wang","year":"2018","journal-title":"Am J Transl Res"},{"key":"2022042010023955100_R20","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.autrev.2012.07.024","article-title":"Gout as autoinflammatory disease: new mechanisms for more appropriated treatment targets","volume":"12","author":"Punzi","year":"2012","journal-title":"Autoimun Rev"}],"container-title":["Modern Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mr\/advance-article-pdf\/doi\/10.1093\/mr\/roab031\/41746640\/roab031.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mr\/article-pdf\/32\/3\/619\/43400488\/roab031.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mr\/article-pdf\/32\/3\/619\/43400488\/roab031.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T06:03:13Z","timestamp":1650434593000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mr\/article\/32\/3\/619\/6348328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,11]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2021,8,11]]},"published-print":{"date-parts":[[2022,4,18]]}},"URL":"https:\/\/doi.org\/10.1093\/mr\/roab031","relation":{},"ISSN":["1439-7595","1439-7609"],"issn-type":[{"value":"1439-7595","type":"print"},{"value":"1439-7609","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,5,1]]},"published":{"date-parts":[[2021,8,11]]}}}