{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T17:13:26Z","timestamp":1765041206112},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T00:00:00Z","timestamp":1630886400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,28]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>The pathogenesis and clinical manifestations of the multisystem inflammatory syndrome in children (MIS-C) has not yet been fully elucidated and there is no clear consensus on its treatment yet.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To evaluate our patients diagnosed with MIS-C and present them to the literature in order to contribute to the better understanding of this new disease, which entered paediatric practice with the SARS-CoV-2 peak.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this study, 17 MIS-C cases diagnosed according to the Centers for Disease Control and Prevention criteria were included.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the patients, 7 (41.2%) had a comorbidity. Gastrointestinal system involvement was the most prominent in the patients (70.6%). Laparotomy was performed in 3 patients due to acute abdomen. Two patients had neurological involvement. Of the patients, 15 (88.2%) received intravenous immunoglobulin and 13 (76.5%) received both intravenous immunoglobulin and methylprednisolone. Two patients received invasive mechanical ventilation and 4 patients received high flow rate nasal cannula oxygen therapy. One of our patients who needed invasive mechanical ventilation and high vasoactive-inotrope support died despite all supportive treatments including plasmapheresis and extracorporeal membrane oxygenation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>MIS-C picture can have a fatal course and may present with severe gastrointestinal and neurological signs. Unnecessary laparotomy should be avoided.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roab042","type":"journal-article","created":{"date-parts":[[2021,12,15]],"date-time":"2021-12-15T13:44:53Z","timestamp":1639575893000},"page":"460-466","source":"Crossref","is-referenced-by-count":4,"title":["COVID-19-associated multisystem inflammatory syndrome in children: Experiences of three centres in Turkey"],"prefix":"10.1093","volume":"32","author":[{"given":"Hakan","family":"Salman","sequence":"first","affiliation":[{"name":"Division of Pediatric Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, Medical School, Suleyman Demirel University, Isparta, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagehan","family":"Aslan","sequence":"additional","affiliation":[{"name":"Division of Pediatric Intensive Care Unit, Department of Pediatrics, Malatya Training and Research Hospital, Malatya, 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Medical School, Department of Pediatrics, Suleyman Demirel University, Isparta, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ceyhun","family":"A\u00e7ar\u0131","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics, Malatya Training and Research Hospital, Malatya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmut","family":"Keskin","sequence":"additional","affiliation":[{"name":"Division of Pediatric Cardiology, Medical School, Department of Pediatrics, Suleyman Demirel University, Isparta, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00fcge","family":"Atar","sequence":"additional","affiliation":[{"name":"Division of Pediatric Endocrinology, Medical School, Department of Pediatrics, Suleyman Demirel University, Isparta, 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