{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:59:03Z","timestamp":1789675143487,"version":"4.0.1"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,9,2]],"date-time":"2021-09-02T00:00:00Z","timestamp":1630540800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>To observe the association between serum vitamin D level and disease activity in juvenile idiopathic arthritis (JIA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The observational study was conducted at a tertiary care hospital during 2017-2019. Patients suffered from JIA were recruited through purposive sampling which was stratified by the disease activity based on the Juvenile Arthritis Disease Activity Score 27 (JADAS27) criteria. Serum vitamin D was estimated alongside other laboratory parameters. The numerical and categorical variables were analysed with appropriate statistical tests.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>40 subjects were studied where inactive disease was observed in nine subjects (22.5%), five subjects (12.5%) were found to be in low disease activity and moderate disease activity groups each, and twenty-one subjects (52.5%) had high disease activity. Considering the total sample size of the study, the mean (SD) JADAS27 score and serum vitamin D level were observed to be 12.02 (11.31) and 23.10 (5.93) respectively. A negative correlation was found between the JADAS27 score and serum vitamin D (r= -0.67). The corrected Chi-square test had revealed significant association between the status of serum vitamin-D and disease activity groups (=16.28; p\u2009&amp;lt;\u2009.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In JIA, higher grade of disease activity was found to be significantly associated with lower serum vitamin D.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roab053","type":"journal-article","created":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T03:58:11Z","timestamp":1634529491000},"page":"792-796","source":"Crossref","is-referenced-by-count":11,"title":["Evaluation of vitamin D profile in juvenile idiopathic arthritis"],"prefix":"10.1093","volume":"32","author":[{"given":"Madhumita","family":"Nandi","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Nilratan Sircar Medical College and Hospital , Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md Abu Sayeed","family":"Mullick","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Nilratan Sircar Medical College and Hospital , Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7075-1040","authenticated-orcid":false,"given":"Arnab","family":"Nandy","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, North Bengal Medical College and Hospital , Darjeeling, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moumita","family":"Samanta","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Nilratan Sircar Medical College and Hospital , Kolkata, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumantra","family":"Sarkar","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Diamond Harbour Medical College and Hospital , South 24 Parganas, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapas Kumar","family":"Sabui","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, R. G. Kar Medical College and Hospital , Kolkata, West Bengal, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,9,2]]},"reference":[{"key":"2022070111362954200_R1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12969-015-0017-9","article-title":"Vitamin D\u2014update for the pediatric rheumatologists","volume":"13","author":"Vojinovic","year":"2015","journal-title":"Pediatr Rheumatol Online J"},{"key":"2022070111362954200_R2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13075-018-1765-y","article-title":"Vitamin D deficiency is associated with higher disease activity and the risk for uveitis in juvenile idiopathic arthritis-data from a German inception cohort","volume":"20","author":"Sengler","year":"2018","journal-title":"Arthritis Res Ther"},{"key":"2022070111362954200_R3","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.3899\/jrheum.131421","article-title":"Determinants of vitamin D levels in children, adolescents, and young adults with juvenile idiopathic arthritis determinants of vitamin D levels in children, adolescents, and young adults with juvenile idiopathic arthritis","volume":"41","author":"Stagi","year":"2014","journal-title":"J Rheumatol"},{"key":"2022070111362954200_R4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.5114\/reum.2013.37250","article-title":"Vitamin D level in children with juvenile idiopathic arthritis and its correlation with clinical picture of the disease","volume":"51","author":"Szyma\u0144ska-Ka\u0142u\u017ca","year":"2013","journal-title":"Reumatologia"},{"key":"2022070111362954200_R5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12969-016-0085-5","article-title":"Clinical outcome measures in juvenile idiopathic arthritis","volume":"14","author":"Consolaro","year":"2016","journal-title":"Pediatr Rheumatol Online 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strongly associated with methotrexate treatment in patients with juvenile idiopathic arthritis","volume":"4","author":"Goralczyk","year":"2015","journal-title":"Bone Abstr"},{"key":"2022070111362954200_R17","article-title":"Serum 25-hydroxyvitamin D in juvenile idiopathic arthritis patients in Finland","volume":"31","author":"Miettinen","year":"2013","journal-title":"Clin Exp Rheumatol"},{"key":"2022070111362954200_R18","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2147\/OARRR.S165916","article-title":"Review of environmental factors and juvenile idiopathic arthritis","volume":"11","author":"Horton","year":"2019","journal-title":"Open Access Rheumatol"},{"key":"2022070111362954200_R19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-020-74861-9","article-title":"Study of vitamin D status and vitamin D receptor polymorphisms in a cohort of Italian patients with juvenile idiopathic 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