{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T08:00:34Z","timestamp":1778313634454,"version":"3.51.4"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,9,10]],"date-time":"2021-09-10T00:00:00Z","timestamp":1631232000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Long-term therapy with low-dose methotrexate (MTX) is widely used in treatment of rheumatic diseases, in children. The purpose of this study was to evaluate liver elasticity in patients with juvenile idiopathic arthritis (JIA) who received MTX and compare the results with control group.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Liver elasticity was evaluated with shear wave elastography (SWE) technique in 25 patients aged 3\u201317\u2009years who were followed up with JIA and received MTX and compared with 25 healthy controls of the same age and weight. Factors that had an effect on liver elasticity were examined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The mean SWE value of patients was 2.64\u2009\u00b1\u20092.13\u2009m\/s and 24.10\u2009\u00b1\u200918.50\u00a0kPa, whereas 1.83\u2009\u00b1\u20090.16\u2009m\/s and 10.09\u2009\u00b1\u20091.83\u00a0kPa in control group. There was a significant difference in liver elasticity in the patient and control groups. When the patients were evaluated as Group 1 (&amp;lt;\u20091000\u2009mg) and Group 2 (\u2265\u20091000\u2009mg) according to the cumulative MTX dose, no significant difference was obtained. There was positive correlation between liver elasticity and weekly MTX dose and age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our study revealed that liver elasticity significantly decreased in patients who received MTX when compared with the control group. The elastography technique will be understood better over time and used safely in many areas.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roab064","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T01:23:25Z","timestamp":1639704205000},"page":"776-782","source":"Crossref","is-referenced-by-count":5,"title":["What is the impact of methotrexate on liver in patients with juvenile idiopathic arthritis? Results of liver SWE performed in a single centre"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9838-2603","authenticated-orcid":false,"given":"Vildan","family":"G\u00fcng\u00f6rer","sequence":"first","affiliation":[{"name":"Department of Pediatric Rheumatology, Selcuk University Faculty of Medicine , Konya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Radiology, Selcuk University Faculty of Medicine , Konya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa Yasir","family":"\u00d6zl\u00fc","sequence":"additional","affiliation":[{"name":"Department of Radiology, Selcuk University Faculty of Medicine , Konya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015e\u00fckr\u00fc","family":"Arslan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Selcuk University Faculty of Medicine , Konya, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,9,10]]},"reference":[{"key":"2022070111364589500_R1","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1056\/NEJM199204163261602","article-title":"Methotrexate in resistant juvenile rheumatoid arthritis. 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