{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T20:03:54Z","timestamp":1788984234693,"version":"build-2803163510"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:00:00Z","timestamp":1632355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,20]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The aim of the present study is to evaluate the presence and frequency of central sensitisation (CS) in primary Sj\u00f6gren Syndrome (pSS) and to determine the effect of CS on sleep quality.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Materials and Methods<\/jats:title>\n                  <jats:p>In this cross-sectional study, 50 patients diagnosed with pSS between the ages of 18 and 75 were included. The healthy control group was composed of 43 healthcare workers. Each participant underwent a physical examination, and demographic data and the medications they used were recorded. Central sensitisation inventory and Pittsburgh Sleep Quality Index questionnaires were filled in to garner data on CS and sleep quality, respectively, from all participants.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>While central sensitisation inventory \u2009&amp;gt;40 was detected in 74% of pSS patients, it was 25.6% in healthy controls, and there is a statistically significant difference between the groups (p\u2009&amp;lt;\u2009.05). A correlation analysis of the central sensitisation inventory and Pittsburgh Sleep Quality Index values of all participants revealed a statistically significant correlation between all parameters other than the duration of sleep (p\u2009&amp;lt;\u2009.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>CS was found to have a negative effect on sleep quality in patients with pSS. We suggest that the cause of widespread pain seen in patients with pSS as the possible development of CS should be considered.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roab075","type":"journal-article","created":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T04:00:32Z","timestamp":1634529632000},"page":"908-914","source":"Crossref","is-referenced-by-count":11,"title":["Central sensitisation in primary Sj\u00f6gren Syndrome and its effect on sleep quality"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6242-7048","authenticated-orcid":false,"given":"Burcu","family":"Metin \u00d6kmen","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital , Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koray","family":"Ayar","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital , Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lale","family":"Altan","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Uludag University Faculty of Medicine , Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zg\u00fcr","family":"Ye\u015fil\u00f6z","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, University of Health Sciences, Bursa Yuksek Ihtisas Training and Research Hospital , Bursa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,9,23]]},"reference":[{"key":"2022082013391019500_R1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/clin.1994.1123","article-title":"Sj\u00f6gren\u2019s syndrome: autoimmune epithelitis","volume":"72","author":"Moutsopoulos","year":"1994","journal-title":"Clin Immunol Immunopathol"},{"key":"2022082013391019500_R2","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1097\/MD.0b013e318181e6af","article-title":"Primary Sj\u00f6gren\u2019s syndrome in Spain: clinical and immunologic expression in 1010 patients","volume":"87","author":"Ramos-Casals","year":"2008","journal-title":"Medicine (Baltimore)"},{"key":"2022082013391019500_R3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.berh.2015.05.002","article-title":"Pain in primary Sj\u00f6gren\u2019s syndrome","volume":"29","author":"Vitali","year":"2015","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2022082013391019500_R4","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1212\/WNL.39.3.390","article-title":"Peripheral neuropathy in primary Sj\u00f6gren\u2019s syndrome","volume":"39","author":"Mellgren","year":"1989","journal-title":"Neurology"},{"key":"2022082013391019500_R5","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1097\/00005792-198207000-00004","article-title":"Neurologic complications of primary Sj\u00f6gren\u2019s syndrome","volume":"61","author":"Alexander","year":"1982","journal-title":"Medicine (Baltimore)"},{"key":"2022082013391019500_R6","first-page":"876","article-title":"Involvement of the peripheral nervous system in primary Sj\u00f6gren\u2019s syndrome","volume":"60","author":"Barendregt","year":"2001","journal-title":"Ann Rheum Dis"},{"key":"2022082013391019500_R7","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s11916-011-0181-7","article-title":"Diagnosis and treatment of pain in small-fiber neuropathy","volume":"15","author":"Hovaguimian","year":"2011","journal-title":"Curr Pain Headache Rep"},{"key":"2022082013391019500_R8","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.jpain.2009.06.012","article-title":"Central sensitization: a generator of pain hypersensitivity by central neural plasticity","volume":"10","author":"Latremoliere","year":"2009","journal-title":"J Pain"},{"key":"2022082013391019500_R9","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1007\/s00108-009-2474-z","article-title":"Chronic pain management","volume":"50","author":"Rothstein","year":"2009","journal-title":"Internist"},{"key":"2022082013391019500_R10","doi-asserted-by":"crossref","DOI":"10.1186\/ar3306","article-title":"The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia","volume":"13","author":"Lee","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"2022082013391019500_R11","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.smrv.2007.09.001","article-title":"Sleep and rheumatologic disorders","volume":"12","author":"Abad","year":"2008","journal-title":"Sleep Med Rev"},{"key":"2022082013391019500_R12","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00011-006-6067-1","article-title":"The relevance of sleep abnormalities to chronic inflammatory conditions","volume":"56","author":"Ranjbaran","year":"2007","journal-title":"Inflamm Res"},{"key":"2022082013391019500_R13","first-page":"71","article-title":"Sleep disturbances, fibromyalgia and primary Sjogren\u2019s syndrome","volume":"15","author":"Tishler","year":"1997","journal-title":"Clin Exp Rheumatol"},{"key":"2022082013391019500_R14","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1093\/rheumatology\/32.12.1072","article-title":"Sleep disturbances in patients with primary Sjogren\u2019s syndrome","volume":"32","author":"Gudbjornsson","year":"1993","journal-title":"Br J Rheumatol"},{"key":"2022082013391019500_R15","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1002\/acr.21956","article-title":"Pain severity and neuropathic pain symptoms in primary Sjogren\u2019s syndrome: a comparison study of seropositive and seronegative Sjogren\u2019s syndrome patients","volume":"65","author":"Segal","year":"2013","journal-title":"Arthritis Care Res"},{"key":"2022082013391019500_R16","first-page":"373","article-title":"Sleep quality in patients with primary Sjogren\u2019s syndrome","volume":"34","author":"Priori","year":"2016","journal-title":"Clin Exp Rheumatol"},{"key":"2022082013391019500_R17","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/rheumatology\/keq023","article-title":"Sleepiness or fatigue? Can we detect treatable causes of tiredness in primary Sjogren\u2019s syndrome?","volume":"49","author":"Theander","year":"2010","journal-title":"Rheumatology"},{"key":"2022082013391019500_R18","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1111\/j.1468-2982.2006.01166.x","article-title":"The natural history of headache: predictors of onset and recovery","volume":"26","author":"Boardman","year":"2006","journal-title":"Cephalalgia"},{"key":"2022082013391019500_R19","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s10067-019-04749-1","article-title":"The important role of central sensitization in chronic musculoskeletal pain seen in different rheumatic diseases","volume":"39","author":"Guler","year":"2020","journal-title":"Clin Rheumatol"},{"key":"2022082013391019500_R20","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1080\/14397595.2020.1780076","article-title":"Central sensitization and its relationship with health profile in Beh\u00e7et\u2019s disease","volume":"31","author":"Ayar","year":"2021","journal-title":"Mod Rheumatol"},{"key":"2022082013391019500_R21","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1111\/papr.12440","article-title":"Establishing clinically relevant severity levels for the central sensitization inventory","volume":"17","author":"Neblett","year":"2017","journal-title":"Pain Practice: The Official Journal of World Institute of Pain"},{"key":"2022082013391019500_R22","article-title":"Validity and reliability of the Turkish version of central sensitization in Turkish","volume-title":"Thesis","author":"D\u00fczce","year":"2018"},{"key":"2022082013391019500_R23","doi-asserted-by":"crossref","first-page":"487","DOI":"10.5664\/jcsm.27286","article-title":"Clinical guideline for the evaluation and management of chronic insomnia in adults","volume":"4","author":"Schutte-Rodin","year":"2008","journal-title":"J Clin Sleep Med"},{"key":"2022082013391019500_R24","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.sleep.2010.04.020","article-title":"Validation of the Brazilian Portuguese version of the Pittsburgh sleep quality index","volume":"12","author":"Bertolazi","year":"2011","journal-title":"Sleep Med"},{"key":"2022082013391019500_R25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.neuro.051508.135531","article-title":"Neuropathic pain: a maladaptive response of the nervous system to damage","volume":"32","author":"Costigan","year":"2009","journal-title":"Annu Rev Neurosci"},{"key":"2022082013391019500_R26","doi-asserted-by":"crossref","first-page":"625","DOI":"10.3233\/BMR-160685","article-title":"Central sensitization in chronic low back pain: a narrative review","volume":"29","author":"Sanzarello","year":"2016","journal-title":"J Back Musculoskelet Rehabil"},{"key":"2022082013391019500_R27","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1590\/bjpt-rbf.2014.0100","article-title":"The role of sensitization in musculoskeletal shoulder pain","volume":"19","author":"Borstad","year":"2015","journal-title":"Braz J Phys Ther"},{"key":"2022082013391019500_R28","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.berh.2010.01.011","article-title":"Chronic widespread pain in the spectrum of rheumatological diseases","volume":"25","author":"Atzeni","year":"2011","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2022082013391019500_R29","doi-asserted-by":"crossref","first-page":"457","DOI":"10.4065\/mcp.2010.0738","article-title":"Improving the recognition and diagnosis of fibromyalgia","volume":"86","author":"Arnold","year":"2011","journal-title":"Mayo Clin Proc"},{"key":"2022082013391019500_R30","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.3899\/jrheum.090942","article-title":"Comorbidities in patients with primary Sj\u00f6gren\u2019s syndrome: a registry-based case-control study","volume":"37","author":"Kang","year":"2010","journal-title":"J Rheumatol"},{"key":"2022082013391019500_R31","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1007\/s00296-014-2972-8","article-title":"Fibromyalgia in patients with other rheumatic diseases: prevalence and relationship with disease activity","volume":"34","author":"Haliloglu","year":"2014","journal-title":"Rheumatol Int"},{"key":"2022082013391019500_R32","first-page":"S9","article-title":"Prevalence and clinical impact of fibromyalgia in patients with primary Sj\u00f6gren\u2019s syndrome","volume":"34","author":"Choi","year":"2016","journal-title":"Clin Exp Rheumatol"},{"key":"2022082013391019500_R33","first-page":"28","article-title":"Fibromyalgia prevalence and associated factors in primary Sj\u00f6gren\u2019s syndrome patients in a large cohort from the Spanish Society of Rheumatology registry (SJOGRENSER)","volume":"35","author":"Torrente-Segarra","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"2022082013391019500_R34","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1177\/0961203313518623","article-title":"Sleep disorders and systemic lupus erythematosus","volume":"23","author":"Palagini","year":"2014","journal-title":"Lupus"},{"key":"2022082013391019500_R35","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bbi.2014.10.004","article-title":"Effect of long-term sleep restriction and subsequent recovery sleep on the diurnal rhythms of white blood cell subpopulations","volume":"47","author":"Lasselin","year":"2015","journal-title":"Brain Behav Immun"},{"key":"2022082013391019500_R36","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1097\/01.PSY.0000091382.61178.F1","article-title":"Sleep enhances the human antibody response to hepatitis a vaccination","volume":"65","author":"Lange","year":"2003","journal-title":"Psychosom Med"},{"key":"2022082013391019500_R37","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.3904\/kjim.2017.158","article-title":"Impact of sleep quality on clinical features of primary Sj\u00f6gren\u2019s syndrome","volume":"34","author":"Chung","year":"2019","journal-title":"Korean J Intern Med"},{"key":"2022082013391019500_R38","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1590\/1516-3180.2019.0251.r1.1912019","article-title":"Correlation of sleep quality with fatigue and disease activity among patients with primary Sj\u00f6gren\u2019s syndrome: a cross-sectional study","volume":"138","author":"Dardin","year":"2020","journal-title":"Sao Paulo Med J"}],"container-title":["Modern Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mr\/advance-article-pdf\/doi\/10.1093\/mr\/roab075\/41928236\/roab075.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mr\/article-pdf\/32\/5\/908\/45487229\/roab075.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mr\/article-pdf\/32\/5\/908\/45487229\/roab075.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T13:39:41Z","timestamp":1661002781000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mr\/article\/32\/5\/908\/6374264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9,23]]},"references-count":38,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,9,23]]},"published-print":{"date-parts":[[2022,8,20]]}},"URL":"https:\/\/doi.org\/10.1093\/mr\/roab075","relation":{},"ISSN":["1439-7595","1439-7609"],"issn-type":[{"value":"1439-7595","type":"print"},{"value":"1439-7609","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,9,1]]},"published":{"date-parts":[[2021,9,23]]}}}