{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:07:05Z","timestamp":1792786025921,"version":"4.5.0"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T00:00:00Z","timestamp":1634342400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP19ek0109356 20ek0109356h0003"],"award-info":[{"award-number":["JP19ek0109356 20ek0109356h0003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Health, Labour and Welfare of Japan","award":["19FC1007"],"award-info":[{"award-number":["19FC1007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,20]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We aimed to assess the clinical features of human T-cell leukaemia virus type 1 (HTLV-1)-positive rheumatoid arthritis (RA) patients. Furthermore, we investigated the impact of HTLV-1 infection on incidences of serious infections requiring hospitalisation (SIH) and malignancies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 150 sex- and age-matched HTLV-1-negative and 50 HTLV-1-positive RA patients were enrolled from the HTLV-1 RA Miyazaki Cohort Study. Clinical and laboratory data were collected from this cohort database. The incidence rate (IR) for SIH and malignancies from 2015 to 2020 was analysed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median age and female ratio in the study population were 70 years old and 80%, respectively. Although no differences were found in inflammatory marker values between the two groups, the patient global assessment and Health Assessment Questionnaire scores were higher in HTLV-1-positive RA patients. In HTLV-1-negative RA patients, the IR for SIH was 6.37\/100 person-years (PY) and 1.32\/100 PY for malignancies. In HTLV-1-positive RA patients, SIH occurred in 11.1\/100 PY and malignancies in 2.46\/100 PY. The crude IR ratio comparing SIH between two groups was 1.74 (95% confidence interval, 1.04\u20132.84), which was a significant increase.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HTLV-1-positive RA patients may worsen RA symptoms. HTLV-1 may be a risk factor for SIH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/mr\/roab077","type":"journal-article","created":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T14:23:12Z","timestamp":1634739792000},"page":"866-874","source":"Crossref","is-referenced-by-count":8,"title":["High incidence of serious infections requiring hospitalisation in human T-cell leukaemia virus type 1-positive rheumatoid arthritis: A case-controlled observational study"],"prefix":"10.1093","volume":"32","author":[{"given":"Yayoi","family":"Hashiba","sequence":"first","affiliation":[{"name":"Department of Respirology, Rheumatology, Infectious Diseases and Neurology, Internal Medicine, University of Miyazaki , Miyazaki, Japan"},{"name":"Institute of Rheumatology, Zenjinkai Shimin-no-Mori Hospital , Miyazaki, 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