{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:35:53Z","timestamp":1791646553453,"version":"4.3.4"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,11,27]],"date-time":"2021-11-27T00:00:00Z","timestamp":1637971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Ministry of Health Labour and Welfare Japan","award":["20FC1044"],"award-info":[{"award-number":["20FC1044"]}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP17ek0109121"],"award-info":[{"award-number":["JP17ek0109121"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,8,20]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To develop a proposal for remission criteria and a framework for a treat-to-target (T2T) algorithm for Takayasu arteritis (TAK).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A study group of the large-vessel vasculitis group of the Japanese Research Committee of the Ministry of Health, Labour and Welfare for Intractable Vasculitis consists of 10 rheumatologists, 5 cardiologists, 1 nephrologist, 1 vascular surgeon, 1 cardiac surgeon, and 2 paediatric rheumatologists. A Delphi survey of remission criteria items was circulated among the study group over four reiterations. To develop the T2T algorithm, the study group conducted four face-to-face meetings and two rounds of Delphi together with three patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Initial literature review resulted in a list of 117 candidate items for remission criteria, of which 56 items with a mean score of \u22654 (0\u20135) were extracted including disease activity domains and treatment\/comorbidity domains. The study group provided six overarching principles for the T2T algorithm, two recommendations on treatment goals, five on evaluation of disease activity and imaging findings including positron emission tomography\u2013computed tomography, and two on treatment intensification.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>We developed a T2T algorithm and proposals for standardised remission criteria by means of a Delphi exercise. These will guide future evaluation of different TAK treatment regimens.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roab081","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T11:35:09Z","timestamp":1638358509000},"page":"930-937","source":"Crossref","is-referenced-by-count":12,"title":["Establishing clinical remission criteria and the framework of a treat-to-target\u00a0algorithm for Takayasu arteritis: Results of a Delphi exercise carried out by an expert panel of the Japan Research Committee of the Ministry of Health, Labour and Welfare for intractable vasculitis"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7181-7494","authenticated-orcid":false,"given":"Takahiko","family":"Sugihara","sequence":"first","affiliation":[{"name":"Department of Lifetime Clinical Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University , Tokyo, Japan"},{"name":"Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine , Kawasaki, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikazu","family":"Nakaoka","sequence":"additional","affiliation":[{"name":"Department of Vascular Physiology, National Cerebral and Cardiovascular Center Research Institute , Suita, Japan"},{"name":"Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine , Suita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhito A","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Chronic Kidney Disease and Cardiovascular Disease, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Yoshifuji","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University , Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Maejima","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tokyo Medical and Dental University , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Watanabe","sequence":"additional","affiliation":[{"name":"First Department of Physiology, Kawasaki Medical School , Kurashiki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eisuke","family":"Amiya","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Graduate School of Medicine , Tokyo, Japan"},{"name":"Department of Therapeutic Strategy for Heart Failure, The University of Tokyo , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Tanemoto","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Surgery, Kawasaki Medical School , Kurashiki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuro","family":"Miyata","sequence":"additional","affiliation":[{"name":"Department of Medical Education, School of Medicine, International University of Health and Welfare , Chiba, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuka","family":"Umezawa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Manabe","sequence":"additional","affiliation":[{"name":"Department of Vascular Physiology, National Cerebral and Cardiovascular Center Research Institute , Suita, Japan"},{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of Medicine , Suita, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Ishizaki","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine , Ehime, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsuyoshi","family":"Shirai","sequence":"additional","affiliation":[{"name":"Department of Hematology and Rheumatology, Tohoku University Graduate School of Medicine , Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Nagafuchi","sequence":"additional","affiliation":[{"name":"Division of Rheumatology and Allergy, Department of Internal Medicine, St. Marianna University School of Medicine , Kawasaki, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Hasegawa","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine , Ehime, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako","family":"Miyamae","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology, Institute of Rheumatology, Tokyo Women\u2019s Medical University School of Medicine , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Niiro","sequence":"additional","affiliation":[{"name":"Department of Medical Education, Kyushu University , Fukuoka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuichi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Graduate School of Medicine, Yokohama City University , Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Ishii","sequence":"additional","affiliation":[{"name":"Clinical Research, Innovation and Education Center, Tohoku University Hospital , Sendai, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitsuaki","family":"Isobe","sequence":"additional","affiliation":[{"name":"Sakakibara Heart Institute , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayoshi","family":"Harigai","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, Tokyo Women\u2019s Medical University School of Medicine , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,11,27]]},"reference":[{"key":"2022082013391386700_R1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.ijcard.2013.01.022","article-title":"Takayasu arteritis revisited: current diagnosis and treatment","volume":"168","author":"Isobe","year":"2013","journal-title":"Int J Cardiol"},{"key":"2022082013391386700_R2","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1253\/circj.CJ-11-1108","article-title":"Improved prognosis of Takayasu arteritis over the past decade\u2014comprehensive analysis of 106 patients","volume":"76","author":"Ohigashi","year":"2012","journal-title":"Circ J"},{"key":"2022082013391386700_R3","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1161\/CIRCULATIONAHA.114.012547","article-title":"Current clinical features of new patients with Takayasu arteritis observed from cross-country research in Japan: age and sex specificity","volume":"132","author":"Watanabe","year":"2015","journal-title":"Circulation"},{"key":"2022082013391386700_R4","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1002\/acr.24055","article-title":"Patterns of arterial disease in Takayasu arteritis and giant cell arteritis","volume":"72","author":"Gribbons","year":"2020","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"2022082013391386700_R5","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jjcc.2016.07.009","article-title":"Effects of immunosuppressive and biological agents on refractory Takayasu arteritis patients unresponsive to glucocorticoid treatment","volume":"69","author":"Ohigashi","year":"2017","journal-title":"J Cardiol"},{"key":"2022082013391386700_R6","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1136\/annrheumdis-2019-215672","article-title":"2018 update of the EULAR recommendations for the management of large vessel vasculitis","volume":"79","author":"Hellmich","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"2022082013391386700_R7","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1136\/annrheumdis-2017-211878","article-title":"Efficacy and safety of tocilizumab in patients with refractory Takayasu arteritis: results from a randomised, double-blind, placebo-controlled, phase 3 trial in Japan (the TAKT study)","volume":"77","author":"Nakaoka","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"2022082013391386700_R8","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1253\/circj.CJ-19-0773","article-title":"JCS 2017 guideline on management of vasculitis syndrome- digest version","volume":"84","author":"Isobe","year":"2020","journal-title":"Circ J"},{"key":"2022082013391386700_R9","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/art.1780390303","article-title":"The development and initial validation of the Systemic Lupus International Collaborating Clinics\/American College of Rheumatology damage index for systemic lupus erythematosus","volume":"39","author":"Gladman","year":"1996","journal-title":"Arthritis Rheumatol"},{"key":"2022082013391386700_R10","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-020-02171-6","article-title":"Associated factors of poor treatment outcomes in patients with giant cell arteritis: clinical implication of large vessel lesions","volume":"22","author":"Sugihara","year":"2020","journal-title":"Arthritis Res Ther"},{"key":"2022082013391386700_R11","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1002\/art.40037","article-title":"A randomized, double-blind trial of abatacept (CTLA-4Ig) for the treatment of Takayasu arteritis","volume":"69","author":"Langford","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"2022082013391386700_R12","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1093\/rheumatology\/keq171","article-title":"Assessment of disease activity and progression in Takayasu\u2019s arteritis with Disease Extent Index-Takayasu","volume":"49","author":"Aydin","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"2022082013391386700_R13","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1093\/rheumatology\/ket128","article-title":"Development and initial validation of the Indian Takayasu Clinical Activity Score (ITAS2010)","volume":"52","author":"Misra","year":"2013","journal-title":"Rheumatology (Oxford)"},{"key":"2022082013391386700_R14","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.3899\/jrheum.161467","article-title":"Development of a core set of outcome measures for large-vessel vasculitis: report from OMERACT 2016","volume":"44","author":"Sreih","year":"2017","journal-title":"J Rheumatol"},{"key":"2022082013391386700_R15","article-title":"Characteristics and treatment outcomes of Takayasu Arteritis in a nationwide, retrospective cohort study in Japan","volume":"70","author":"Uchida","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"2022082013391386700_R16","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.3899\/jrheum.181072","article-title":"Update on outcome measure development in large-vessel vasculitis: report from OMERACT 2018","volume":"46","author":"Aydin","year":"2019","journal-title":"J Rheumatol"},{"key":"2022082013391386700_R17","doi-asserted-by":"crossref","first-page":"919","DOI":"10.7326\/0003-4819-120-11-199406010-00004","article-title":"Takayasu arteritis","volume":"120","author":"Kerr","year":"1994","journal-title":"Ann Intern Med"},{"key":"2022082013391386700_R18","doi-asserted-by":"crossref","first-page":"2427","DOI":"10.1093\/rheumatology\/kez630","article-title":"Long-term efficacy and safety of tocilizumab in refractory Takayasu arteritis: final results of the randomized controlled phase 3 TAKT study","volume":"59","author":"Nakaoka","year":"2020","journal-title":"Rheumatology (Oxford)"},{"key":"2022082013391386700_R19","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2019-001020","article-title":"Management of Takayasu arteritis: a systematic literature review informing the 2018 update of the EULAR recommendation for the management of large vessel vasculitis","volume":"5","author":"Agueda","year":"2019","journal-title":"RMD Open"},{"key":"2022082013391386700_R20","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2019-001003","article-title":"Systematic literature review informing the 2018 update of the EULAR recommendation for the management of large vessel vasculitis: focus on giant cell arteritis","volume":"5","author":"Monti","year":"2019","journal-title":"RMD Open"},{"key":"2022082013391386700_R21","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1136\/annrheumdis-2017-212649","article-title":"EULAR recommendations for the use of imaging in large vessel vasculitis in clinical practice","volume":"77","author":"Dejaco","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"2022082013391386700_R22","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.jcmg.2012.01.013","article-title":"Role of FDG PET-CT in Takayasu arteritis: sensitive detection of recurrences","volume":"5","author":"Tezuka","year":"2012","journal-title":"JACC Cardiovasc Imaging"},{"key":"2022082013391386700_R23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0145855","article-title":"Vessel wall inflammation of takayasu arteritis detected by contrast-enhanced magnetic resonance imaging: association with disease distribution and activity","volume":"10","author":"Kato","year":"2015","journal-title":"PLoS One"},{"key":"2022082013391386700_R24","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1136\/annrheumdis-2018-213102","article-title":"Comparison of magnetic resonance angiography and (18) F-fluorodeoxyglucose positron emission tomography in large-vessel vasculitis","volume":"77","author":"Quinn","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"2022082013391386700_R25","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/art.40379","article-title":"(18) F-fluorodeoxyglucose-positron emission tomography as an imaging biomarker in a prospective, longitudinal cohort of patients with large vessel vasculitis","volume":"70","author":"Grayson","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"2022082013391386700_R26","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3899\/jrheum.181222","article-title":"Effect of treatment on imaging, clinical, and serologic assessments of disease activity in large-vessel vasculitis","volume":"47","author":"Banerjee","year":"2020","journal-title":"J Rheumatol"},{"key":"2022082013391386700_R27","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1002\/acr.24117","article-title":"Outcome measures in large vessel vasculitis: relationship between patient-, physician-, imaging-, and laboratory-based assessments","volume":"72","author":"Rimland","year":"2020","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"2022082013391386700_R28","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1002\/art.40876","article-title":"Glucocorticoid dosages and acute-phase reactant levels at giant cell arteritis flare in a randomized trial of tocilizumab","volume":"71","author":"Stone","year":"2019","journal-title":"Arthritis Rheumatol"},{"key":"2022082013391386700_R29","doi-asserted-by":"crossref","first-page":"2226","DOI":"10.1002\/art.39157","article-title":"Takayasu arteritis and ulcerative colitis: high rate of co-occurrence and genetic overlap","volume":"67","author":"Terao","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"2022082013391386700_R30","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.ajhg.2013.05.024","article-title":"Two susceptibility loci to Takayasu arteritis reveal a synergistic role of the IL12B and HLA-B regions in a Japanese population","volume":"93","author":"Terao","year":"2013","journal-title":"Am J Hum Genet"},{"key":"2022082013391386700_R31","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1136\/annrheumdis-2015-207526","article-title":"Evidence for treating rheumatoid arthritis to target: results of a systematic literature search update","volume":"75","author":"Stoffer","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"2022082013391386700_R32","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1136\/annrheumdis-2013-205139","article-title":"Treat-to-target in systemic lupus erythematosus: recommendations from an international task force","volume":"73","author":"van Vollenhoven","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"2022082013391386700_R33","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1002\/acr.22589","article-title":"Treatment algorithms in systemic lupus erythematosus","volume":"67","author":"Muangchan","year":"2015","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"2022082013391386700_R34","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jjcc.2020.12.011","article-title":"Evaluation of tocilizumab for intractable Takayasu arteritis and (18) F-fluorodeoxyglucose-positron emission tomography for detecting inflammation under tocilizumab treatment","volume":"77","author":"Isobe","year":"2021","journal-title":"J Cardiol"}],"container-title":["Modern Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mr\/advance-article-pdf\/doi\/10.1093\/mr\/roab081\/41393643\/roab081.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mr\/article-pdf\/32\/5\/930\/45487262\/roab081.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mr\/article-pdf\/32\/5\/930\/45487262\/roab081.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T13:40:00Z","timestamp":1661002800000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mr\/article\/32\/5\/930\/6444401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,27]]},"references-count":34,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2021,11,27]]},"published-print":{"date-parts":[[2022,8,20]]}},"URL":"https:\/\/doi.org\/10.1093\/mr\/roab081","relation":{},"ISSN":["1439-7595","1439-7609"],"issn-type":[{"value":"1439-7595","type":"print"},{"value":"1439-7609","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,9,1]]},"published":{"date-parts":[[2021,11,27]]}}}