{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T01:45:33Z","timestamp":1776217533835,"version":"3.50.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T00:00:00Z","timestamp":1633478400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["CNPq 304984\/2020-5 to CAS"],"award-info":[{"award-number":["CNPq 304984\/2020-5 to CAS"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["FAPESP 2015\/03756-4"],"award-info":[{"award-number":["FAPESP 2015\/03756-4"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"N\u00facleo de Apoio \u00e0 Pesquisa \u2018Sa\u00fade da Crian\u00e7a e do Adolescente\u2019 da USP","award":["NAP-CriAd"],"award-info":[{"award-number":["NAP-CriAd"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We evaluated cardiac function in juvenile idiopathic arthritis (JIA) patients by 2D speckle-tracking echocardiography (2DSTE) and to assess possible associations with clinical, laboratorial, and treatment data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A group of 42 JIA patients and 42 healthy controls were evaluated using both conventional echocardiography and 2DSTE. JIA patients underwent clinical and laboratory assessment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Conventional echocardiography data demonstrated normal left ventricular (LV) ejection fraction in both groups (71 vs. 71%; p\u2009=\u2009.69). 2DSTE analysis demonstrated that JIA patients presented significantly lower LV global systolic longitudinal strain (LVGLS) (\u221218.76 vs. \u221222%; p\u2009&amp;lt;\u2009.0001), LV systolic strain rate (LVSSR) (1.06 vs. 1.32\u2009s\u22121; p\u2009&amp;lt;\u2009.0001), LV diastolic strain rate (LVDSR) (1.58 vs. 1.8\u2009s\u22121; p\u2009&amp;lt;\u2009.0137), right ventricular global systolic strain (RVGLS) (\u221224.1% vs. \u221227.7%; p\u2009=\u2009.0002), and right ventricular systolic strain rate (RVSSR) (1.4 vs. 1.8\u2009s\u22121; p\u2009=\u2009.0035). JIA patients under biological agents presented higher LVGLS (p\u2009=\u2009.02) and RVLS (p\u2009=\u2009.01). We also detected an association between LVGLS and C-reactive protein [CRP; \u221220% in normal CRP (10\/42) vs. \u221218% in elevated CRP patients (32\/42), p\u2009=\u2009.03].<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>JIA patients present different echocardiographic status from healthy patients. Moreover, our data suggest that JIA patients under biological agents present association with better cardiac function as shown by strain analysis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/mr\/roab086","type":"journal-article","created":{"date-parts":[[2021,11,2]],"date-time":"2021-11-02T06:06:30Z","timestamp":1635833190000},"page":"1122-1128","source":"Crossref","is-referenced-by-count":0,"title":["Heart function in juvenile idiopathic arthritis patients: A biventricular two-dimensional speckle-tracking echocardiography study"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0840-0300","authenticated-orcid":false,"given":"Alessandro C","family":"Lianza","sequence":"first","affiliation":[{"name":"Echocardiography Laboratory, Instituto da Crian\u00e7a e do Adolescente do Hospital das Clinicas da Faculdade de Medicina, Universidade de S\u00e3o Paulo , S\u00e3o Paulo,","place":["Brazil"]},{"name":"Echocardiography laboratory, Hospital Israelita Albert Einstein , S\u00e3o Paulo,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela N","family":"Leal","sequence":"additional","affiliation":[{"name":"Echocardiography Laboratory, Instituto da Crian\u00e7a e do Adolescente do Hospital das Clinicas da Faculdade de Medicina, Universidade de S\u00e3o Paulo , S\u00e3o Paulo,","place":["Brazil"]},{"name":"Echocardiography laboratory, Hospital S\u00edrio Lib\u00e2nes , S\u00e3o Paulo,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00e1dia E","family":"Aikawa","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit, Instituto da Crian\u00e7a e do Adolescente do Hospital das Clinicas da Faculdade de Medicina, Universidade de S\u00e3o Paulo , S\u00e3o Paulo,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katia T","family":"Kozu","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit, Instituto da Crian\u00e7a e do Adolescente do Hospital das Clinicas da Faculdade de Medicina, Universidade de S\u00e3o Paulo , S\u00e3o Paulo,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria De F\u00e1tima R","family":"Diniz","sequence":"additional","affiliation":[{"name":"Echocardiography Laboratory, Instituto da Crian\u00e7a e do Adolescente do Hospital das Clinicas da Faculdade de Medicina, Universidade de S\u00e3o Paulo , S\u00e3o Paulo,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen S S","family":"Sawamura","sequence":"additional","affiliation":[{"name":"Echocardiography Laboratory, Instituto da Crian\u00e7a e do Adolescente do Hospital das Clinicas da Faculdade de Medicina, Universidade de S\u00e3o Paulo , S\u00e3o Paulo,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina R B","family":"Menezes","sequence":"additional","affiliation":[{"name":"Echocardiography Laboratory, Instituto da Crian\u00e7a e do Adolescente do Hospital das Clinicas da Faculdade de Medicina, Universidade de S\u00e3o Paulo , S\u00e3o Paulo,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camila Lino","family":"Martins","sequence":"additional","affiliation":[{"name":"Echocardiography Laboratory, Instituto da Crian\u00e7a e do Adolescente do Hospital das Clinicas da Faculdade de Medicina, Universidade de S\u00e3o Paulo , S\u00e3o Paulo,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia M","family":"Campos","sequence":"additional","affiliation":[{"name":"Pediatric Rheumatology Unit, Instituto da Crian\u00e7a e do Adolescente do Hospital das Clinicas da Faculdade de Medicina, Universidade de S\u00e3o Paulo , S\u00e3o Paulo,","place":["Brazil"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana 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