{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T09:19:34Z","timestamp":1783329574980,"version":"3.54.6"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Dr Sanshiro Shiraishi (Director of Shiraishi Hospital Imabari city Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Indeed, serum amyloid A (SAA) and C-reactive protein (CRP) reportedly seem to have moderate correlation, but discrepancies between CRP and SAA levels have often been reported in patients with early rheumatoid arthritis (ERA). This study aimed to determine the reasons for this discrepancy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>ERA patients (n\u2009=\u2009206) were enrolled and treated with anti-RA drugs. Clinical features and disease activities were estimated. CRP and SAA levels were monitored, and the SAA\/CRP ratio was compared. Correlations between CRP and SAA levels in individuals and between individuals and disease activity scores were examined.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In a follow-up study, the SAA\/CRP ratio remained almost constant over time in the same patients. However, SAA\/CRP ratios differed widely between patients (0.233\u2013106.3). In patients with high SAA\/CRP ratios (&amp;gt;6.52), many (26.2%) had abnormal SAA values only. In patients with low SAA\/CRP ratios (&amp;lt;6.52), not a few (6.8%) exhibited abnormal CRP values only.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The SAA\/CRP ratio remained virtually constant in the same patients but differed dramatically between patients, which clarifies the discrepancy between CRP and SAA levels. CRP is the better marker in low-ratio patients but not in high-ratio patients; the SAA\/CRP ratio is critical for its interpretation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roab097","type":"journal-article","created":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T16:40:46Z","timestamp":1637253646000},"page":"1035-1040","source":"Crossref","is-referenced-by-count":4,"title":["Discrepancy between SAA and CRP levels linked to the difference of SAA\/CRP ratio in the patients with early rheumatoid arthritis"],"prefix":"10.1093","volume":"32","author":[{"given":"Hiroshi","family":"Uda","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Higashiosaka City Medical Center , Higashiosaka City, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rika","family":"Ebisu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Higashiosaka City Medical Center , Higashiosaka City, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiji","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Higashiosaka City Medical Center , Higashiosaka City, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osamu","family":"Saiki","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Higashiosaka City Medical Center , Higashiosaka City, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,11,25]]},"reference":[{"key":"2022101711271577300_R1","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1056\/NEJM199902113400607","article-title":"Acute-phase proteins and other systemic responses to inflammation","volume":"340","author":"Gabay","year":"1999","journal-title":"N Engl J Med"},{"key":"2022101711271577300_R2","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2474-15-368","article-title":"How age and sex affect the erythrocyte sedimentation rate and C-reactive protein in early rheumatoid arthritis","volume":"15","author":"Siemons","year":"2014","journal-title":"BMC Musculoskelet Disord"},{"key":"2022101711271577300_R3","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1080\/10245330701340734","article-title":"ESR or CRP? 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