{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:00:04Z","timestamp":1790384404091,"version":"4.1.0"},"reference-count":82,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T00:00:00Z","timestamp":1640822400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Synovitis-Acne-Pustulosis-Hyperostosis-Osteitis (SAPHO) syndrome is a rare inflammatory osteoarticular disorder, which encompassed many diseases, including pustulotic arthro-osteitis (PAO). Musculoskeletal manifestations, including osteitis, synovitis, and hyperostosis, are the hallmarks of the SAPHO syndrome and affect a variety of regions of the body. Recent survey indicated that more than 80% of cases of SAPHO syndrome in Japan were PAO, originally proposed by Sonozaki et\u00a0al. in 1981, whereas severe acne was the most commonly reported skin ailment amongst participants with SAPHO syndrome in Israel. Prevalence of SAPHO syndrome remains unavailable, whereas the prevalence of palmoplantar pustulosis (PPP) was reported to be 0.12% in Japan, and 10\u201330% of patients with PPP had PAO. SAPHO syndrome and PAO are predominantly found in patients in the third through fifth decades of life, and a female predominance is seen in both groups. The diagnosis is typically made by a rheumatologist or dermatologist. Identification of a variety of the clinical, radiological, and laboratory features outlined, as well as diagnostic criteria, are used to make the diagnosis. Goals of treatment seek to maximize health-related quality of life, preventing structural changes and destruction, and normalizing physical function and social participation. Finally, we review the non-pharmacological and pharmacological managements.<\/jats:p>","DOI":"10.1093\/mr\/roab103","type":"journal-article","created":{"date-parts":[[2021,12,30]],"date-time":"2021-12-30T10:12:53Z","timestamp":1640859173000},"page":"665-674","source":"Crossref","is-referenced-by-count":35,"title":["SAPHO syndrome and pustulotic arthro-osteitis"],"prefix":"10.1093","volume":"32","author":[{"given":"Mitsumasa","family":"Kishimoto","sequence":"first","affiliation":[{"name":"Department of Nephrology and Rheumatology, Kyorin University School of Medicine , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism, Nephrology and Rheumatology, Kochi Medical School Hospital , Nankoku, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeyoshi","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Rheumatology, National Hospital Organization, Osaka Minami Medical Center , Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoko","family":"Ishihara","sequence":"additional","affiliation":[{"name":"Japan Medical Research Foundation , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gautam A","family":"Deshpande","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, Juntendo University School of Medicine , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keizo","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Kyorin University School of Medicine , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Okada","sequence":"additional","affiliation":[{"name":"Immuno-Rheumatology Center, St. Luke\u2019s International Hospital , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Komagata","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Kyorin University School of Medicine , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satomi","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Seibo International Catholic Hospital , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukari","family":"Okubo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Tokyo Medical University , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Tomita","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Biomaterial Science, Osaka University Graduate School of Medicine , Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Kaname","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Kyorin University School of Medicine , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,12,30]]},"reference":[{"key":"2022070111365342300_R1","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/art.1780040609","article-title":"Acne conglobata and arthritis","volume":"4","author":"Windom","year":"1961","journal-title":"Arthritis Rheum"},{"key":"2022070111365342300_R2","first-page":"329","article-title":"Subacute and chronic \u201csymmetrical\u201d osteomyelitis","volume":"15","author":"Giedion","year":"1972","journal-title":"Ann Radiol"},{"key":"2022070111365342300_R3","doi-asserted-by":"crossref","first-page":"192","DOI":"10.7326\/0003-4819-87-2-192","article-title":"Sternocostoclavicular hyperostosis: painful swelling of sternum, clavicles, and upper ribs. Report of two cases","volume":"87","author":"Kohler","year":"1977","journal-title":"Ann Intern Med"},{"key":"2022070111365342300_R4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/j.1346-8138.1977.tb01011.x","article-title":"Orthopedic symptoms in pustular bacterid (pustulosis palmaris et plantaris): Tietze\u2019s syndrome and arthritis of manubriosternal joint due to focal infection","volume":"4","author":"Ishibashi","year":"1977","journal-title":"J Dermatol"},{"key":"2022070111365342300_R5","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/BF00379164","article-title":"Clinical features of 22 cases with \u201cinter-sterno-costo-clavicular ossification\u201d. A new rheumatic syndrome","volume":"95","author":"Sonozaki","year":"1979","journal-title":"Arch Orthop Trauma Surg"},{"key":"2022070111365342300_R6","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1136\/ard.40.6.547","article-title":"Clinical features of 53 cases with pustulotic arthro-osteitis","volume":"40","author":"Sonozaki","year":"1981","journal-title":"Ann Rheum Dis"},{"key":"2022070111365342300_R7","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/ard.40.6.554","article-title":"Incidence of arthro-osteitis in patients with pustulosis palmaris et plantaris","volume":"40","author":"Sonozaki","year":"1981","journal-title":"Ann Rheum Dis"},{"key":"2022070111365342300_R8","first-page":"187","article-title":"Acne-pustulosis-hyperostosis-osteitis syndrome. Results of a national survey. 85 cases","volume":"54","author":"Chamot","year":"1987","journal-title":"Rev Rhum Mal Osteoartic"},{"key":"2022070111365342300_R9","first-page":"109","article-title":"Synovitis-acne-pustulosis hyperostosis osteomyelitis syndrome (SAPHO). A new syndrome among the spondyloarthropathies?","volume":"6","author":"Benhamou","year":"1988","journal-title":"Clin Exp Rheumatol"},{"key":"2022070111365342300_R10","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0950-3579(94)80022-7","article-title":"The SAPHO syndrome","volume":"8","author":"Kahn","year":"1994","journal-title":"Baillieres Clin Rheumatol"},{"key":"2022070111365342300_R11","first-page":"1635","article-title":"SAPHO syndrome","volume":"54","author":"Hayem","year":"2004","journal-title":"Rev Prat"},{"key":"2022070111365342300_R12","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.crad.2011.08.014","article-title":"SAPHO: what radiologists should know","volume":"67","author":"Depasquale","year":"2012","journal-title":"Clin Radiol"},{"key":"2022070111365342300_R13","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s40744-020-00235-2","article-title":"The diagnosis and treatment of adult patients with SAPHO syndrome: controversies revealed in a multidisciplinary international survey of physicians","volume":"7","author":"Furer","year":"2020","journal-title":"Rheumatol Ther"},{"key":"2022070111365342300_R14","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s11832-014-0627-7","article-title":"SAPHO syndrome: a review","volume":"9","author":"Rukavina","year":"2015","journal-title":"J Child Orthop"},{"key":"2022070111365342300_R15","first-page":"2017","article-title":"Why the \u201cSAPHO\u201d syndrome?","volume":"22","author":"Kahn","year":"1995","journal-title":"J Rheumatol"},{"key":"2022070111365342300_R16","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/art.22087","article-title":"Conundrums in nosology: synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome and spondylarthritis","volume":"55","author":"Rohekar","year":"2006","journal-title":"Arthritis Rheum"},{"key":"2022070111365342300_R17","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1136\/ard.47.10.809","article-title":"Palmoplantar pustulosis and sternocostoclavicular arthro-osteitis","volume":"47","author":"Edlund","year":"1988","journal-title":"Ann Rheum Dis"},{"key":"2022070111365342300_R18","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1002\/1529-0131(199904)42:4<818::AID-ANR29>3.0.CO;2-G","article-title":"Sustained response to doxycycline therapy in two patients with SAPHO syndrome","volume":"42","author":"Ballara","year":"1999","journal-title":"Arthritis Rheum"},{"key":"2022070111365342300_R19","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1007\/s003930070059","article-title":"Azithromycin: an anti-inflammatory effect in chronic recurrent multifocal osteomyelitis? A preliminary report","volume":"59","author":"Schilling","year":"2000","journal-title":"Z Rheumatol"},{"key":"2022070111365342300_R20","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.berh.2011.01.017","article-title":"The SAPHO syndrome\u2014are microbes involved?","volume":"25","author":"Assmann","year":"2011","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2022070111365342300_R21","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3109\/08916934.2014.906582","article-title":"TH17 cells are increased in the peripheral blood of patients with SAPHO syndrome","volume":"47","author":"Firinu","year":"2014","journal-title":"Autoimmunity"},{"key":"2022070111365342300_R22","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1080\/14397595.2018.1469580","article-title":"Serum levels of proinflammatory, anti-inflammatory cytokines, and RANKL\/OPG in synovitis, acne, pustulosis, hyperostosis, and osteitis (SAPHO) syndrome","volume":"29","author":"Zhang","year":"2019","journal-title":"Mod Rheumatol"},{"key":"2022070111365342300_R23","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1053\/sarh.2000.8371","article-title":"SAPHO: rare or just not recognized?","volume":"30","author":"Van Doornum","year":"2000","journal-title":"Semin Arthritis Rheum"},{"key":"2022070111365342300_R24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0049-0172(99)80027-4","article-title":"SAPHO syndrome: a long-term follow-up study of 120 cases","volume":"29","author":"Hayem","year":"1999","journal-title":"Semin Arthritis Rheum"},{"key":"2022070111365342300_R25","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/ijd.14788","article-title":"Characteristics of Japanese patients with pustulotic arthro-osteitis associated with palmoplantar pustulosis: a multicenter study","volume":"59","author":"Yamamoto","year":"2020","journal-title":"Int J Dermatol"},{"key":"2022070111365342300_R26","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1093\/rheumatology\/keh295","article-title":"Pamidronate in the treatment of childhood SAPHO syndrome","volume":"43","author":"Kerrison","year":"2004","journal-title":"Rheumatology (Oxford)"},{"key":"2022070111365342300_R27","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1111\/ced.13926","article-title":"A novel CARD14 variant, homozygous c.526G&gt;C (p.Asp176His), in an adolescent Japanese patient with palmoplantar pustulosis","volume":"44","author":"Tobita","year":"2019","journal-title":"Clin Exp Dermatol"},{"key":"2022070111365342300_R28","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2014-006450","article-title":"Epidemiology of psoriasis and palmoplantar pustulosis: a nationwide study using the Japanese national claims database","volume":"5","author":"Kubota","year":"2015","journal-title":"BMJ Open"},{"key":"2022070111365342300_R29","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1001\/archderm.1935.01470060002001","article-title":"Pustular bacterids of the hands and feet","volume":"32","author":"Andrews","year":"1935","journal-title":"Arch Dermatol Syph"},{"key":"2022070111365342300_R30","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1111\/1346-8138.15100","article-title":"Pathogenic role of palatine tonsils in palmoplantar pustulosis: a review","volume":"46","author":"Harabuchi","year":"2019","journal-title":"J Dermatol"},{"key":"2022070111365342300_R31","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/j.1365-2133.1930.tb09380.x","article-title":"Acrodermatitis continua vel perstans (dermatitis repens) and psoriasis pustulosa","volume":"42","author":"Barber","year":"1930","journal-title":"Br J Dermatol"},{"key":"2022070111365342300_R32","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1111\/jdv.14386","article-title":"European consensus statement on phenotypes of pustular psoriasis","volume":"31","author":"Navarini","year":"2017","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2022070111365342300_R33","first-page":"161","article-title":"Clinical analyses of focus tonsil and related diseases in Japan","volume":"523","author":"Kataura","year":"1996","journal-title":"Acta Otolaryngol"},{"key":"2022070111365342300_R34","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1111\/1346-8138.14348","article-title":"Treatment outcome and prognostic factors of tonsillectomy for palmoplantar pustulosis and pustulotic arthro-osteitis: a retrospective subjective and objective quantitative analysis of 138 patients","volume":"45","author":"Takahara","year":"2018","journal-title":"J Dermatol"},{"key":"2022070111365342300_R35","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jdermsci.2007.12.010","article-title":"Possible involvement of T cell co-stimulator in pustulosis palmaris et plantaris via the induction of inducible co-stimulator in chronic focal infections","volume":"50","author":"Sakiyama","year":"2008","journal-title":"J Dermatol Sci"},{"key":"2022070111365342300_R36","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1080\/00016489950181431","article-title":"Increased Interleukin-6, Interferon-gamma and tumor necrosis factor-alpha production by tonsillar mononuclear cells stimulated with alpha-streptococci in patients with pustulosis palmaris et plantaris","volume":"119","author":"Murakata","year":"1999","journal-title":"Acta Otilaringol"},{"key":"2022070111365342300_R37","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1007\/s10875-010-9451-0","article-title":"Up-regulation of beta-1 integrin on tonsillar T cells and its induction by in vitro stimulation with alpha-streptococci in patients with pustulosis Palmaris et Plantaris","volume":"30","author":"Ueda","year":"2010","journal-title":"J Clin Immunol"},{"key":"2022070111365342300_R38","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.clim.2005.01.001","article-title":"Increase of activated T-cells and up-regulation of Smad7 without elevation of TGF-beta expression in tonsils from patients with pustulosis palmaris et plantaris","volume":"115","author":"Takahara","year":"2005","journal-title":"Clin Immunol"},{"key":"2022070111365342300_R39","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.jdermsci.2018.12.003","article-title":"Dysbiosis of oral microbiota in palmoplantar pustulosis patients","volume":"93","author":"Kouno","year":"2019","journal-title":"J Dermatol Sci"},{"key":"2022070111365342300_R40","first-page":"225","article-title":"Women with palmoplantar pustulosis have disturbed calcium homeostasis and a high prevalence of diabetes mellitus and psychiatric disorders: a case-control study","volume":"85","author":"Hagforsen","year":"2005","journal-title":"Acta Derm Venereol"},{"key":"2022070111365342300_R41","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.1111\/ijd.14023","article-title":"Comorbidities of Japanese patients with palmoplantar pustulosis: a report from a single centaer","volume":"57","author":"Hiraiwa","year":"2018","journal-title":"Int J Dermatol"},{"key":"2022070111365342300_R42","doi-asserted-by":"crossref","first-page":"7","DOI":"10.4137\/IJTR.S19985","article-title":"The aryl hydrocarbon receptor: a review of its role in the physiology and pathology of the integument and its relationship to the tryptophan metabolism","volume":"8","author":"Noakes","year":"2015","journal-title":"Int J Tryptophan Res"},{"key":"2022070111365342300_R43","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-020-02309-6","article-title":"Anterior chest wall in SAPHO syndrome: magnetic resonance imaging findings","volume":"22","author":"Yu","year":"2020","journal-title":"Arthritis Res Ther"},{"key":"2022070111365342300_R44","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1080\/14397595.2017.1372874","article-title":"Clinical features and radiological findings of 67 patients with SAPHO syndrome","volume":"28","author":"Okuno","year":"2018","journal-title":"Mod Rheumatol"},{"key":"2022070111365342300_R45","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.autrev.2008.07.030","article-title":"SAPHO syndrome and infections","volume":"8","author":"Govoni","year":"2009","journal-title":"Autoimmun Rev"},{"key":"2022070111365342300_R46","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0049-0172(93)80070-V","article-title":"Sternoclavicular hyperostosis","volume":"22","author":"Saghafi","year":"1993","journal-title":"Semin Arthritis Rheum"},{"key":"2022070111365342300_R47","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0889-857X(21)00720-1","article-title":"SAPHO syndrome","volume":"18","author":"Kahn","year":"1992","journal-title":"Rheum Dis Clin North Am"},{"key":"2022070111365342300_R48","first-page":"1302","article-title":"Propionibacterium acnes isolated from sternal osteitis in a patient with SAPHO syndrome","volume":"23","author":"Kotilainen","year":"1996","journal-title":"J Rheumatol"},{"key":"2022070111365342300_R49","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1093\/rheumatology\/40.2.170","article-title":"The sternoclavicular syndrome: experience from a district general hospital and results of a national postal survey","volume":"40","author":"Kalke","year":"2001","journal-title":"Rheumatology (Oxford)"},{"key":"2022070111365342300_R50","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/1346-8138.12272","article-title":"Pustulotic arthro-osteitis associated with palmoplantar pustulosis","volume":"40","author":"Yamamoto","year":"2013","journal-title":"J Dermatol"},{"key":"2022070111365342300_R51","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.jaad.2005.07.024","article-title":"The psoriasis variant palmoplantar pustulosis can be improved after cessation of smoking","volume":"54","author":"Michaelsson","year":"2006","journal-title":"J Am Acad Dermatol"},{"key":"2022070111365342300_R52","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1007\/s10067-020-05322-x","article-title":"The effectiveness of treatments for patients with SAPHO syndrome: a follow-up study of 24 cases from a single center and review of literature","volume":"40","author":"Huang","year":"2020","journal-title":"Clin Rheumatol"},{"key":"2022070111365342300_R53","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1346-8138.1998.tb02381.x","article-title":"Four cases of pustulotic arthro-osteitis","volume":"25","author":"Jang","year":"1998","journal-title":"J Dermatol"},{"key":"2022070111365342300_R54","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000248698","article-title":"Neutrophil chemotaxis in patients with pustulotic arthro-osteitis","volume":"176","author":"Jurik","year":"1988","journal-title":"Dermatologica"},{"key":"2022070111365342300_R55","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.3233\/BMR-169646","article-title":"Pustulotic arthro-osteitis (Sonozaki syndrome): a rare case report","volume":"30","author":"Resorlu","year":"2017","journal-title":"J Back Musculoskelet Rahabil"},{"key":"2022070111365342300_R56","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1093\/rheumatology\/keh149","article-title":"SAPHO syndrome treated with pamidronate: an open-label study of 10 patients","volume":"43","author":"Amital","year":"2004","journal-title":"Rheumatology (Oxford)"},{"key":"2022070111365342300_R57","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.jbspin.2014.01.017","article-title":"SAPHO syndrome treatment with intravenous pamidronate. Retrospective Study of 22 Patients","volume":"81","author":"Delattre","year":"2014","journal-title":"Joint Bone Spine"},{"key":"2022070111365342300_R58","first-page":"663","article-title":"Efficacy of bisphosphonates in patients with synovitis, acne, pustulosis, hyperostosis, and osteitis syndrome: a prospective open study","volume":"3","author":"Li","year":"2019","journal-title":"Clin Exp Rheumatol"},{"key":"2022070111365342300_R59","article-title":"A case of SAPHO syndrome with the lesions limited to the skull","volume":"4","author":"Oguro","year":"2020","journal-title":"Rheumatol Adv Pract"},{"key":"2022070111365342300_R60","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3109\/14397595.2013.874760","article-title":"Antibiotics may be useful in the treatment of SAPHO syndrome","volume":"24","author":"Colina","year":"2014","journal-title":"Mod Rheumatol"},{"key":"2022070111365342300_R61","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.3109\/14397595.2013.874744","article-title":"Severe inflammation associated with synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome was markedly ameliorated by single use of minocycline","volume":"24","author":"Takizawa","year":"2014","journal-title":"Mod Rheumatol"},{"key":"2022070111365342300_R62","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1111\/ijd.13608","article-title":"Palmoplantar pustulosis and pustulotic arthro-osteitis treatment with potassium iodide and tetracycline, a novel remedy with an old drug: a review of 25 patients","volume":"56","author":"Hayashi","year":"2017","journal-title":"Int J Dermatol"},{"key":"2022070111365342300_R63","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1159\/000439401","article-title":"Cefcapene pivoxil hydrochloride is a potentially new treatment for palmoplantar pustulosis with pustulotic arthro-osteitis","volume":"231","author":"Murakami","year":"2015","journal-title":"Dermatology"},{"key":"2022070111365342300_R64","doi-asserted-by":"crossref","DOI":"10.1186\/ar2812","article-title":"Efficacy of antibiotic therapy for SAPHO syndrome is lost after its discontinuation: an interventional study","volume":"11","author":"Assmann","year":"2009","journal-title":"Arthritis Res Ther"},{"key":"2022070111365342300_R65","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1046\/j.1365-2230.2001.00759.x","article-title":"Successful treatment of pustulotic arthro-osteitis (Sonozaki syndrome) with systemic cyclosporin","volume":"26","author":"Vaccaro","year":"2001","journal-title":"Clin Exp Dermatol"},{"key":"2022070111365342300_R66","first-page":"758","article-title":"A pilot study of medium-dose cyclosporine for the treatment of palmoplantar pustulosis complicated with pustulotic arthro-osteitis","volume":"20","author":"Hayama","year":"2010","journal-title":"Eur J Dermatol"},{"key":"2022070111365342300_R67","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3899\/jrheum.140342","article-title":"The SAPHO syndrome: a single-center study of 41 adult patients","volume":"42","author":"Aljuhani","year":"2015","journal-title":"J Rheumatol"},{"key":"2022070111365342300_R68","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.ijwd.2020.01.009","article-title":"Sulfasalazine in dermatology: a lesser explored drug with broad therapeutic potential","volume":"6","author":"Mushtaq","year":"2020","journal-title":"Int J Womens Dermatol"},{"key":"2022070111365342300_R69","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1517\/13543784.15.10.1229","article-title":"Pharmacological management of SAPHO syndrome","volume":"15","author":"Olivieri","year":"2006","journal-title":"Expert Opin Investig Drugs"},{"key":"2022070111365342300_R70","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1684\/ejd.2019.3660","article-title":"Successful treatment of pustulotic arthro-osteitis with apremilast: a case report with follow-up MRI","volume":"29","author":"Takama","year":"2019","journal-title":"Eur J Dermatol"},{"key":"2022070111365342300_R71","doi-asserted-by":"crossref","DOI":"10.1111\/dth.13249","article-title":"Effects of apremilast on pustulotic arthro-osteitis in a real-world setting: report of five cases","volume":"33","author":"Kikuchi","year":"2020","journal-title":"Dermatol Ther"},{"key":"2022070111365342300_R72","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.semarthrit.2018.04.003","article-title":"Biologics in SAPHO syndrome: a systematic review","volume":"48","author":"Daoussis","year":"2019","journal-title":"Semin Arthritis Rheum"},{"key":"2022070111365342300_R73","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1001\/jamadermatol.2019.1394","article-title":"Efficacy and safety of guselkumab in Japanese patients with palmoplantar pustulosis: a phase 3 randomized clinical trial","volume":"155","author":"Terui","year":"2019","journal-title":"JAMA Dermatol"},{"key":"2022070111365342300_R74","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1111\/jdv.16355","article-title":"Efficacy of guselkumab in a subpopulation with pustulotic arthro-osteitis through week 52: an exploratory analysis of a phase 3, randomized, double-blind, placebo-controlled study in Japanese patients with palmoplantar pustulosis","volume":"34","author":"Yamamoto","year":"2020","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2022070111365342300_R75","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.3899\/jrheum.091086","article-title":"Tumor necrosis factor-alpha blockers in SAPHO syndrome","volume":"37","author":"Ben Abdelghani","year":"2010","journal-title":"J Rheumatol"},{"key":"2022070111365342300_R76","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1093\/rheumatology\/kei221","article-title":"In SAPHO syndrome anti-TNF-alpha therapy may induce persistent amelioration of osteoarticular complaints, but may exacerbate cutaneous manifestations","volume":"45","author":"Massara","year":"2006","journal-title":"Rheumatology (Oxford)"},{"key":"2022070111365342300_R77","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.jbspin.2017.05.016","article-title":"IL-23\/Th17 targeted therapies in SAPHO syndrome. A case series","volume":"84","author":"Wendling","year":"2017","journal-title":"Joint Bone Spine"},{"key":"2022070111365342300_R78","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.jaad.2019.01.066","article-title":"Secukinumab for moderate-to-severe palmoplantar pustular psoriasis: results of the 2PRECISE study","volume":"80","author":"Mrowietz","year":"2019","journal-title":"J Am Acad Dermatol"},{"key":"2022070111365342300_R79","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1136\/annrheumdis-2020-217250","article-title":"Efficacy of tofacitinib in synovitis, acne, pustulosis, hyperostosis and osteitis syndrome: a pilot study with clinical and MRI evaluation","volume":"79","author":"Li","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"2022070111365342300_R80","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2020-217854","article-title":"Off-label use of tofacitinib: a potential trearment option for SAPHO syndrome","author":"Xie","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"2022070111365342300_R81","doi-asserted-by":"crossref","first-page":"e167","DOI":"10.1111\/1346-8138.14191","article-title":"Granulocyte and monocyte adsorption apheresis for palmoplantar pustulosis with extra-palmoplantar lesions and pustulotic arthro-osteitis","volume":"45","author":"Arimura","year":"2018","journal-title":"J Dermatol"},{"key":"2022070111365342300_R82","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/1346-8138.14717","article-title":"Evaluation of the efficacy of granulocyte and monocyte adsorption apheresis on skin manifestation and joint symptoms of patients with pustulotic arthro-osteitis","volume":"46","author":"Kawakami","year":"2019","journal-title":"J Dermatol"}],"container-title":["Modern Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mr\/advance-article-pdf\/doi\/10.1093\/mr\/roab103\/42244744\/roab103.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mr\/article-pdf\/32\/4\/665\/44367348\/roab103.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mr\/article-pdf\/32\/4\/665\/44367348\/roab103.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,15]],"date-time":"2023-11-15T00:22:05Z","timestamp":1700007725000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mr\/article\/32\/4\/665\/6489784"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,30]]},"references-count":82,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021,12,30]]},"published-print":{"date-parts":[[2022,7,1]]}},"URL":"https:\/\/doi.org\/10.1093\/mr\/roab103","relation":{},"ISSN":["1439-7595","1439-7609"],"issn-type":[{"value":"1439-7595","type":"print"},{"value":"1439-7609","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,7,1]]},"published":{"date-parts":[[2021,12,30]]}}}