{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T16:06:48Z","timestamp":1782490008173,"version":"3.54.5"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T00:00:00Z","timestamp":1639699200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study aimed to assess the factors influencing bone erosion (BE) in patients with gout using dual-energy gemstone spectral imaging computer tomography.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We compared the clinical data, laboratory indices, and tissue urate levels at the monosodium urate (MSU) bone interface measured by dual-energy gemstone spectral imaging computed tomography of 87 gout patients with (n\u2009=\u200941) and without (n\u2009=\u200946) BE. Logistic regression analysis was used to investigate the risk factors associated with BE.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In total, 47.1% of patients with gout had BE. The disease duration, serum uric acid, tissue urate levels, and the presence of tophi were significantly higher (p\u2009&amp;lt;\u2009.05) in gout patients with BE than in those without BE. Longer disease duration (odds ratio\u2009=\u20091.11, 95% confidence interval: 1.00\u20131.24, p\u2009&amp;lt;\u2009.05) and increased tissue urate levels (odds ratio\u2009=\u20091.01, 95% confidence interval: 1.00\u20131.02, p\u2009&amp;lt;\u2009.05) were independently associated with BE. Tissue urate levels at the MSU-bone interface were correlated with the presence of tophi (r\u2009=\u20090.62, p\u2009&amp;lt;\u2009.001), BE (r\u2009=\u20090.51, p\u2009&amp;lt;\u2009.001), renal calculus (r\u2009=\u20090.24, p\u2009=\u2009.03), and serum uric acid levels (r\u2009=\u20090.23, p\u2009=\u2009.03).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>This study found that longer disease duration and elevated tissue urate concentrations at the MSU-bone interface were associated with BE in patients with gout.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roab116","type":"journal-article","created":{"date-parts":[[2021,12,17]],"date-time":"2021-12-17T07:21:27Z","timestamp":1639725687000},"page":"1170-1174","source":"Crossref","is-referenced-by-count":3,"title":["Factors associated with bone erosion in patients with gout: A dual-energy gemstone spectral imaging computed tomography study"],"prefix":"10.1093","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8389-8781","authenticated-orcid":false,"given":"Xiaofei","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Immunology, Hainan Hospital, Chinese PLA General Hospital , Sanya, Hainan, China"},{"name":"These authors contributed equally to this work"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baige","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hainan Hospital, Chinese PLA General Hospital , Sanya, Hainan, China"},{"name":"Department of Radiology, The First Affiliated Hospital of Jinan University , Guangzhou, Guangdong, China"},{"name":"These authors contributed equally to this work"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaohuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hainan Hospital, Chinese PLA General Hospital , Sanya, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyan","family":"Mo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Hainan Hospital, Chinese PLA General Hospital , Sanya, Hainan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongfeng","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Hainan Hospital, Chinese PLA General Hospital , Sanya, Hainan, China"},{"name":"Department of Rheumatology and Immunology, The First Medical Center , Chinese PLA General Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, Hainan Hospital, Chinese PLA General Hospital , Sanya, Hainan, China"},{"name":"Department of Rheumatology and Immunology, The First Medical Center , Chinese PLA 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