{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T17:17:26Z","timestamp":1776273446085,"version":"3.50.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T00:00:00Z","timestamp":1644883200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Grants-in-Aid for Scientific Research-KAKENHI from Ministry","award":["21K12119"],"award-info":[{"award-number":["21K12119"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The objective of the study was to determine the seasonal changes in the initiation of biological disease-modifying antirheumatic drugs (bDMARDs) and methotrexate (MTX) using big claims data.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We counted the monthly number of initial administrations of each bDMARD and MTX in patients with rheumatoid arthritis (RA) between April 2010 and March 2017. Data were collected from the National Database of Health Insurance Claims and Specific Health Checkups of Japan. This database covers more than 95% of Japanese citizens. Seasonal changes in the number of initiations were determined. Patient claims were also classified according to drugs, districts, gender, and ages.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The initiation of bDMARDs and MTX administration varied according to the season in a sine curve shape, with the highest numbers in May to July and the lowest numbers in November to January. The same changing pattern was observed among each bDMARD, district, gender, and age groups particularly when the number was on the higher side.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>We noted an apparent seasonal change in the number of bDMARDs initiated, with a peak during spring, suggesting an exacerbation of RA in the spring in Japan. These changes are overlooked in daily practice and are only visible using big data.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roab122","type":"journal-article","created":{"date-parts":[[2022,2,15]],"date-time":"2022-02-15T01:58:51Z","timestamp":1644890331000},"page":"46-53","source":"Crossref","is-referenced-by-count":4,"title":["Seasonal exacerbation of rheumatoid arthritis detected by big claims data analysis: A retrospective population study"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0439-9384","authenticated-orcid":false,"given":"Fumihiko","family":"Ando","sequence":"first","affiliation":[{"name":"Division of Medical Informatics and Management, Chiba University Hospital , Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8644-3173","authenticated-orcid":false,"given":"Katsuhiko","family":"Takabayashi","sequence":"additional","affiliation":[{"name":"Division of Medical Informatics and Management, Chiba University Hospital , Chiba, Japan"},{"name":"Department of Internal Medicine, Sanwa Hospital , Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinsuke","family":"Fujita","sequence":"additional","affiliation":[{"name":"Department of Clinical Design and Medicine, Center for Preventive Medical Sciences, Chiba University , Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Nakajima","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, Chiba University Hospital , Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideki","family":"Hanaoka","sequence":"additional","affiliation":[{"name":"Clinical Research Center, Chiba University Hospital , Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Division of Medical Informatics and Management, Chiba University Hospital , Chiba, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,2,15]]},"reference":[{"key":"2023011210463722600_R1","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1136\/annrheumdis-2013-204573","article-title":"EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update","volume":"73","author":"Smolen","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"2023011210463722600_R2","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1093\/rheumatology\/kev019","article-title":"Effectiveness of biologic DMARDs in monotherapy versus in combination with synthetic DMARDs in rheumatoid arthritis: data from the Swiss Clinical Quality Management Registry","volume":"54","author":"Gabay","year":"2015","journal-title":"Rheumatology"},{"key":"2023011210463722600_R3","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/S0140-6736(18)31619-2","article-title":"Improving observational studies in the era of big data","volume":"392","author":"Gill","year":"2018","journal-title":"Lancet"},{"key":"2023011210463722600_R4","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s40801-016-0089-y","article-title":"Claims data analysis of tumor necrosis factor inhibitor treatment dosing among patients with rheumatoid arthritis: a systematic review of methods","volume":"3","author":"Krack","year":"2016","journal-title":"Drugs Real World Outcomes"},{"key":"2023011210463722600_R5","first-page":"621","article-title":"Costs of tumor necrosis factor blockers per treated patient using real-world drug data in a managed care population","volume":"19","author":"Schabert","year":"2013","journal-title":"J Manag Care Pharm"},{"key":"2023011210463722600_R6","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1136\/annrheumdis-2016-209131","article-title":"Real-world comparative risks of herpes virus infections in tofacitinib and biologic-treated patients with rheumatoid arthritis","volume":"75","author":"Curtis","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"2023011210463722600_R7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/14397595.2018.1447264","article-title":"Comparing the effectiveness of biological disease-modifying antirheumatic drugs using real-world data","volume":"29","author":"Takabayashi","year":"2019","journal-title":"Mod Rheumatol"},{"key":"2023011210463722600_R8","doi-asserted-by":"crossref","DOI":"10.1016\/j.dib.2019.103780","article-title":"Data regarding fracture incidence according to fracture site, month, and age group obtained from the large public health insurance claim database in Japan","volume":"23","author":"Hayashi","year":"2019","journal-title":"Data Brief"},{"key":"2023011210463722600_R9","first-page":"345","article-title":"Enabling patient traceability using anonymized personal identifiers in Japanese universal health insurance claims database","volume":"2019","author":"Sato","year":"2019","journal-title":"AMIA 2019 Inform Summit"},{"key":"2023011210463722600_R10","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00296-017-3900-5","article-title":"Wide difference in biologics usage and expenditure for the treatment of patients with rheumatoid arthritis in each prefecture in Japan analyzed using \u2018National Database of Health Insurance Claims and Specific Health Checkups of Japan\u2019","volume":"38","author":"Kamata","year":"2018","journal-title":"Rheumatol Int"},{"key":"2023011210463722600_R11","first-page":"1","article-title":"Geographic variations in rheumatoid arthritis treatment in Japan: a nationwide retrospective study using the national database of health insurance claims and specific health checkups of Japan","volume":"15","author":"Nakajima","year":"2021","journal-title":"Mod Rheumatol"},{"key":"2023011210463722600_R12","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1111\/1756-185X.13974","article-title":"Prevalence of patients with rheumatoid arthritis and age stratified trends in clinical characteristics and treatment, based on the National Database of Health Insurance Claims and Specific Health Checkups of Japan","volume":"23","author":"Nakajima","year":"2020","journal-title":"Int J Rheum Dis"},{"key":"2023011210463722600_R13","article-title":"Trend in prescription and treatment retention of molecular-targeted drugs in 121,131 Japanese patients with rheumatoid arthritis: a population-based real-world study","author":"Takabayashi","journal-title":"Mod Rheumatol"},{"key":"2023011210463722600_R14","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-020-2118-1","article-title":"Seasonal effect on fatigue, pain and dryness in primary Sj\u00f6gren\u2019s syndrome","volume":"22","author":"Duret","year":"2020","journal-title":"Arthritis Res Ther"},{"key":"2023011210463722600_R15","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2020-001262","article-title":"Incidence and seasonality of type 1 diabetes: a population-based 3-year cohort study using the National Database in Japan","volume":"8","author":"Nishioka","year":"2020","journal-title":"BMJ Open Diabetes Res Care"},{"key":"2023011210463722600_R16","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1093\/rheumatology\/kel414","article-title":"What\u2019s in season for rheumatoid arthritis patients? Seasonal fluctuations in disease activity","volume":"46","author":"Iikuni","year":"2007","journal-title":"Rheumatology"},{"key":"2023011210463722600_R17","doi-asserted-by":"crossref","DOI":"10.1186\/s12891-019-2418-2","article-title":"Influence of seasonal changes on disease activity and distribution of affected joints in rheumatoid arthritis","volume":"20","author":"Mori","year":"2019","journal-title":"BMC Musculoskelet Disord"},{"key":"2023011210463722600_R18","first-page":"887","article-title":"Relationships between rheumatoid arthritis and environment factors","volume":"55","author":"Takizawa","year":"1991","journal-title":"Public Health"},{"key":"2023011210463722600_R19","doi-asserted-by":"crossref","DOI":"10.1186\/s12891-016-0911-4","article-title":"Seasonal variations in fatigue in persons with rheumatoid arthritis: a longitudinal study","volume":"17","author":"Feldthusen","year":"2016","journal-title":"BMC Musculoskelet Disord"},{"key":"2023011210463722600_R20","first-page":"64","article-title":"Seasonal variation of rheumatic diseases","volume":"5","author":"Schlesinger","year":"2005","journal-title":"Discov Med"},{"key":"2023011210463722600_R21","first-page":"1900","article-title":"Seasonal symptom severity in patients with rheumatic disease: a study of 1424 patients","volume":"28","author":"Hawley","year":"2001","journal-title":"J Rheumatol"},{"key":"2023011210463722600_R22","first-page":"1327","article-title":"Weather effects in rheumatoid arthritis: from controversy to consensus. A review","volume":"31","author":"Patberg","year":"2004","journal-title":"J Rheumatol"},{"key":"2023011210463722600_R23","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.1073\/pnas.93.7.2895","article-title":"On the belief that arthritis pain is related to the weather","volume":"93","author":"Redelmeier","year":"1996","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2023011210463722600_R24","first-page":"1309","article-title":"The association between external weather conditions and pain and stiffness in women with rheumatoid arthritis","volume":"24","author":"Drane","year":"1997","journal-title":"J Rheumatol"},{"key":"2023011210463722600_R25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0085376","article-title":"Inverse association between air pressure and rheumatoid arthritis synovitis","volume":"9","author":"Terao","year":"2014","journal-title":"PLoS One"},{"key":"2023011210463722600_R26","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s00296-014-3161-5","article-title":"Does rheumatoid arthritis disease activity correlate with weather conditions?","volume":"35","author":"Savage","year":"2015","journal-title":"Rheumatol Int"},{"key":"2023011210463722600_R27","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s004840050041","article-title":"The association between arthritis and the weather","volume":"40","author":"Aikman","year":"1997","journal-title":"Int J Biometeorol"},{"key":"2023011210463722600_R28","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1093\/rheumatology\/keq099","article-title":"Whether the weather influences pain? Results from the EpiFunD study in North West England","volume":"49","author":"Macfarlane","year":"2010","journal-title":"Rheumatology"},{"key":"2023011210463722600_R29","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1136\/ard.49.3.158","article-title":"Effect of weather conditions on rheumatic patients","volume":"49","author":"Guedj","year":"1990","journal-title":"Ann Rheum Dis"},{"key":"2023011210463722600_R30","doi-asserted-by":"crossref","DOI":"10.1111\/sji.12704","article-title":"The D-vitamin metabolite 1,25(OH)2 D in serum is associated with disease activity and Anti-Citrullinated Protein Antibodies in active and treatment na\u00efve, early Rheumatoid Arthritis Patients","volume":"88","author":"Herly","year":"2018","journal-title":"Scand J Immunol"},{"key":"2023011210463722600_R31","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.3390\/nu5072268","article-title":"Vitamin D status is associated with disease activity among rheumatology outpatients","volume":"5","author":"Sabbagh","year":"2013","journal-title":"Nutrients"},{"key":"2023011210463722600_R32","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3899\/jrheum.090705","article-title":"Vitamin D status and its associations with disease activity and severity in African Americans with recent onset rheumatoid arthritis","volume":"37","author":"Craig","year":"2010","journal-title":"J Rheumatol"},{"key":"2023011210463722600_R33","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1136\/ard.2004.023416","article-title":"Circadian melatonin and cortisol levels in rheumatoid arthritis patients in winter time: a north and south Europe comparison","volume":"64","author":"Cutolo","year":"2005","journal-title":"Ann Rheum Dis"},{"key":"2023011210463722600_R34","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-019-1977-9","article-title":"Respiratory viral infections and the risk of rheumatoid arthritis","volume":"21","author":"Joo","year":"2019","journal-title":"Arthritis Res Ther"},{"key":"2023011210463722600_R35","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1093\/eurheartj\/ehx254","article-title":"UK Biobank: opportunities for cardiovascular research","volume":"40","author":"Littlejohns","year":"2019","journal-title":"Eur Heart J"},{"key":"2023011210463722600_R36","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0304-3959(99)00010-X","article-title":"Rheumatoid arthritis patients show weather sensitivity in daily life, but the relationship is not clinically significant","volume":"81","author":"Gorin","year":"1999","journal-title":"Pain"},{"key":"2023011210463722600_R37","doi-asserted-by":"crossref","DOI":"10.2196\/mhealth.6496","article-title":"Cloudy with a chance of pain: engagement and subsequent attrition of daily data entry in a smartphone pilot study tracking weather, disease severity, and physical activity in patients with rheumatoid arthritis","volume":"5","author":"Reade","year":"2017","journal-title":"JMIR Mhealth Uhealth"}],"container-title":["Modern Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mr\/advance-article-pdf\/doi\/10.1093\/mr\/roab122\/43468044\/roab122.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mr\/article-pdf\/33\/1\/46\/48626527\/roab122.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mr\/article-pdf\/33\/1\/46\/48626527\/roab122.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T11:44:45Z","timestamp":1673523885000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mr\/article\/33\/1\/46\/6528508"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,15]]},"references-count":37,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,2,15]]},"published-print":{"date-parts":[[2023,1,3]]}},"URL":"https:\/\/doi.org\/10.1093\/mr\/roab122","relation":{},"ISSN":["1439-7595","1439-7609"],"issn-type":[{"value":"1439-7595","type":"print"},{"value":"1439-7609","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,1,1]]},"published":{"date-parts":[[2022,2,15]]}}}