{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T22:48:19Z","timestamp":1759963699788,"version":"3.37.3"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T00:00:00Z","timestamp":1640131200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,1,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To investigate efficacy of long-term treatment with denosumab and predictive factors for achievement of treatment goals in patients with postmenopausal osteoporosis (PMO).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We enrolled 111 PMO patients who had T-scores \u2264\u22122.5 either at the lumbar spine (L-) or femoral neck (FN-), who had never been treated for osteoporosis, and who could be followed for at least 3\u2009years. We first evaluated changes in bone mineral density (BMD) for up to 7\u2009years. We next defined the treatment goal as the achievement of a T-score &amp;gt;\u22122.5 at month 36 and performed multivariate analysis to identify predictive factors for achievement of the goal.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Lumbar spine- and femoral neck bone-mineral density increased yearly for 7\u2009years. Among 87 patients with baseline L-T-scores \u2264\u22122.5, better baseline L-T-scores predicted achievement of L-T-scores &amp;gt;\u22122.5 at month 36. The cut-off value for baseline L-T-score was \u22123.4. Among 76 patients with baseline FN-T-scores \u2264\u22122.5, better baseline FN-T-scores predicted achievement of FN-T-scores &amp;gt;\u22122.5 at month 36. The cut-off value for baseline FN-T-scores was \u22122.8.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Long-term treatment with denosumab was effective in PMO patients. As better baseline T-score predicted achievement of T-scores &amp;gt;\u22122.5, early initiation of treatment will contribute to better outcome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roab129","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T01:51:41Z","timestamp":1640224301000},"page":"217-223","source":"Crossref","is-referenced-by-count":3,"title":["Predictive factors for achievement of treatment goals in patients with postmenopausal osteoporosis treated with denosumab"],"prefix":"10.1093","volume":"33","author":[{"given":"Kyosuke","family":"Hattori","sequence":"first","affiliation":[{"name":"Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine , Nagoya, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobunori","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine , Nagoya, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihisa","family":"Kojima","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine , Nagoya, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6951-8575","authenticated-orcid":false,"given":"Shiro","family":"Imagama","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine , Nagoya, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2021,12,22]]},"reference":[{"key":"2023011210490587900_R1","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","article-title":"Osteoporosis: now and the future","volume":"9","author":"Rachner","year":"2011","journal-title":"Lancet"},{"key":"2023011210490587900_R2","volume":"29","author":"Eastell","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"2023011210490587900_R3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4158\/EP161435.GL","article-title":"American Association of clinical endocrinologists and American College of endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis - 2016","volume":"2","author":"Camacho","year":"2016","journal-title":"Endocr Pract"},{"key":"2023011210490587900_R4","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/jbmr.1476","article-title":"Previous fractures at multiple sites increase the risk for subsequent fractures: the global longitudinal study of osteoporosis in women","volume":"27","author":"Gehlbach","year":"2012","journal-title":"J Bone Miner Res"},{"key":"2023011210490587900_R5","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1210\/jc.2013-3461","article-title":"The impact of nonhip nonvertebral fractures in elderly women and men","volume":"99","author":"Bliuc","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"2023011210490587900_R6","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1177\/230949901001800204","article-title":"Mortality after vertebral fractures in a Japanese population","volume":"18","author":"Ikeda","year":"2010","journal-title":"J Orthop Surg (Hong Kong)"},{"key":"2023011210490587900_R7","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1007\/s00198-020-05569-9","article-title":"Is a treat-to-target strategy in osteoporosis applicable in clinical practice? 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