{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:09:16Z","timestamp":1777860556699,"version":"3.51.4"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T00:00:00Z","timestamp":1650499200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Labour Sciences Research","award":["20FC1012"],"award-info":[{"award-number":["20FC1012"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,13]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To describe the long-term clinical course of each manifestation of Beh\u00e7et\u2019s disease (BD) and clarify factors involved in oral ulcer (OU) remission using clinical information of BD patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We retrospectively studied 155 BD patients visiting our hospital (1989\u20132020). We defined remission criteria for each manifestation and examined long-term clinical changes. Classification and regression trees and multivariable analyses were performed to investigate OU prognostic factors; hazard ratios were used to assign scores to prognostic factors deemed significant [OU prognosis score (OuP score)]. Risk stratification was examined by dividing the OuP scores into four stages.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>OUs appeared earliest, with the slowest decline in prevalence observed post-BD diagnosis. OU presence was the most common factor inhibiting complete remission. Young age at OU onset, never smoker, presence of genital ulcers, positive pathergy test, no usage of tumour necrosis factor inhibitors or of immunosuppressants, and long-term non-treatment or symptomatic treatment for OUs were poor OU prognostic factors. Based on multivariable analysis, the area under the curve of the OuP score to predict OU prognosis was 0.678.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Remission criteria for each symptom clarified that OU had the greatest impact on complete BD remission. Faster OU remission was associated with earlier OU therapeutic intervention other than symptomatic treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roac035","type":"journal-article","created":{"date-parts":[[2022,4,21]],"date-time":"2022-04-21T05:35:55Z","timestamp":1650519355000},"page":"566-573","source":"Crossref","is-referenced-by-count":2,"title":["Natural history of Beh\u00e7et\u2019s disease focusing on remission of oral ulcers"],"prefix":"10.1093","volume":"33","author":[{"given":"Takafumi","family":"Tomizuka","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Teikyo University School of Medicine , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirotoshi","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Teikyo University School of Medicine , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mai","family":"Okubo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Teikyo University School of Medicine , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kurumi","family":"Asako","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Teikyo University School of Medicine , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Miyata","sequence":"additional","affiliation":[{"name":"Teikyo University Graduate School of Public Health , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4578-8677","authenticated-orcid":false,"given":"Hajime","family":"Kono","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Teikyo University School of Medicine , Tokyo, 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