{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:13:36Z","timestamp":1790806416084,"version":"4.1.0"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T00:00:00Z","timestamp":1652140800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,13]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Beh\u00e7et\u2019s disease (BD) is a systemic vasculitis affecting many organ systems, with the involvement of all-sized arteries and veins. The study aims to determine the main characteristics of paediatric BD patients and also analyse the clustering phenotypes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Demographic data, clinical manifestations, laboratory features, treatment schedules, and disease outcomes were achieved from patients\u2019 charts retrospectively. A cluster analysis was performed according to the phenotype.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 225 (109 male\/116 female) patients with BD were enrolled in the study. The median ages of disease onset and diagnosis were 131 (36\u2013151) and 156 (36\u2013192) months, respectively. According to cluster analysis, 132 (58.6%) patients belonged to the mucocutaneous-only cluster (C1), while 35 (15.6%) patients fitted to articular type (C2), 25 (11.1%) were in the ocular cluster (C3), 26 (11.6%) were in the vascular cluster (C4), and 7(3.1%) belonged to the gastrointestinal cluster (C5). Ocular and vascular clusters were more common in boys (p\u2009&amp;lt;\u2009.001), while girls usually presented with the mucocutaneous-only cluster. The disease activity at the diagnosis and the last control was higher in ocular, vascular, and gastrointestinal clusters.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These identified juvenile BD clusters express different phenotypes with different outcomes Our analysis may help clinicians to identify the disease subtypes accurately and to arrange personalized treatment.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roac044","type":"journal-article","created":{"date-parts":[[2022,5,10]],"date-time":"2022-05-10T01:35:36Z","timestamp":1652146536000},"page":"574-578","source":"Crossref","is-referenced-by-count":13,"title":["Cluster analysis of paediatric Beh\u00e7et\u2019s disease: Data from The Pediatric Rheumatology Academy-Research Group"],"prefix":"10.1093","volume":"33","author":[{"given":"Ferhat","family":"Demir","sequence":"first","affiliation":[{"name":"Department of Pediatric Rheumatology, Ac\u0131badem Healthcare Group , Yurtcan Soka\u011fl No:1, 34662, \u00dcsk\u00fcdar\/\u0130stanbul 34662, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hafize Emine","family":"S\u00f6nmez","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Faculty of Medicine, Kocaeli University , Kocaeli, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esra","family":"Ba\u011flan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, University of Health Sciences, Sami Ulus Maternity and Children\u2019s Diseases Training and Research Hospital , Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"Akg\u00fcn","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Faculty of Medicine, Istanbul University , Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taner","family":"Co\u015fkuner","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, University of Health Sciences, \u00dcmraniye Training and Research Hospital , Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcl\u00e7in Otar","family":"Yener","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, \u015eanl\u0131urfa Training and Research Hospital , \u015eanl\u0131urfa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K\u00fcbra","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Istanbul Medeniyet University, G\u00f6ztepe Prof. Dr. S\u00fcleyman Yal\u00e7\u0131n City Hospital , Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa","family":"\u00c7akan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, University of Health Sciences, \u00dcmraniye Training and Research Hospital , Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u015eerife G","family":"Karada\u011f","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Erzurum Regional Research and Training Hospital , Erzurum, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Semanur","family":"\u00d6zdel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, University of Health Sciences, Sami Ulus Maternity and Children\u2019s Diseases Training and Research Hospital , Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuray Aktay","family":"Ayaz","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Faculty of Medicine, Istanbul University , Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betul","family":"S\u00f6zeri","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, University of Health Sciences, \u00dcmraniye Training and Research Hospital , Istanbul, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,5,10]]},"reference":[{"key":"2023092217013431100_R1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/art.37715","article-title":"2012 Revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides","volume":"65","author":"Jennette","year":"2013","journal-title":"Arthritis Rheum"},{"key":"2023092217013431100_R2","article-title":"Pediatric onset Beh\u00e7et disease","volume":"22","author":"Ozen","year":"2020","journal-title":"Curr Opin Rheumatol"},{"key":"2023092217013431100_R3","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s11739-019-02046-y","article-title":"Phenotypes in Beh\u00e7et\u2019s syndrome","volume":"14","author":"Seyahi","year":"2019","journal-title":"Intern Emerg Med"},{"key":"2023092217013431100_R4","doi-asserted-by":"crossref","DOI":"10.1007\/s11926-020-00908-5","article-title":"Clusters in pediatric rheumatic diseases","volume":"22","author":"Sag","year":"2020","journal-title":"Curr Rheumatol Rep"},{"key":"2023092217013431100_R5","first-page":"1","article-title":"Distinct clinical characteristics of pediatric Beh\u00e7et\u2019s syndrome: a study from a referral center in China","volume":"16","author":"Zou","year":"2021","journal-title":"Mod Rheumatol"},{"key":"2023092217013431100_R6","first-page":"1078","article-title":"International study group for Beh\u00e7et\u2019s disease","volume":"335","author":"Criteria for Diagnosis of Beh\u00e7et\u2019s Disease","year":"1990","journal-title":"Lancet"},{"key":"2023092217013431100_R7","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1136\/annrheumdis-2015-208491","article-title":"Consensus classification criteria for paediatric Beh\u00e7et\u2019s disease from a prospective observational cohort: PEDBD","volume":"75","author":"Kon\u00e9-Paut","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"2023092217013431100_R8","first-page":"59","article-title":"Recent research into Beh\u00e7et\u2019s disease in Japan","volume":"10","author":"Mizushima","year":"1988","journal-title":"Int J Tissue React"},{"key":"2023092217013431100_R9","article-title":"Iran Beh\u00e7et\u2019s disease dynamic activity measure. Abstracts of the XIIth European Congress of Rheumatology","volume":"32","author":"Davatchi","year":"1991","journal-title":"Hungarian Rheumatol"},{"key":"2023092217013431100_R10","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/rheumatology\/kew486","article-title":"Exploring the variability in Beh\u00e7et\u2019s disease prevalence: a meta-analytical approach","volume":"57","author":"Maldini","year":"2018","journal-title":"Rheumatology (Oxford)"},{"key":"2023092217013431100_R11","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.jaad.2007.10.452","article-title":"Demographic and clinical properties of juvenile-onset Beh\u00e7et\u2019s disease: a controlled multicenter study","volume":"58","author":"Karincaoglu","year":"2008","journal-title":"J Am Acad Dermatol"},{"key":"2023092217013431100_R12","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1007\/s10067-016-3187-z","article-title":"Paediatric Beh\u00e7et\u2019s disease: a UK tertiary centre experience","volume":"35","author":"Nanthapisal","year":"2016","journal-title":"Clin Rheumatol"},{"key":"2023092217013431100_R13","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s10067-021-05896-0","article-title":"Juvenile Beh\u00e7et\u2019s disease: a tertiary center experience","volume":"41","author":"Ekici Tekin","year":"2022","journal-title":"Clin Rheumatol"},{"key":"2023092217013431100_R14","article-title":"Pediatric Beh\u00e7et\u2019s disease","volume":"3","author":"Yildiz","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"2023092217013431100_R15","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3109\/09273948.2011.555592","article-title":"Beh\u00e7et disease in children","volume":"19","author":"Atmaca","year":"2011","journal-title":"Ocul Immunol Inflamm"},{"key":"2023092217013431100_R16","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1093\/rheumatology\/38.5.457","article-title":"Childhood Beh\u00e7et\u2019s disease: clinical features and comparison with adult-onset disease","volume":"38","author":"Krause","year":"1999","journal-title":"Rheumatology (Oxford)"},{"key":"2023092217013431100_R17","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1525-1470.1994.tb00559.x","article-title":"Clinical analysis of 40 cases of childhood-onset Beh\u00e7et\u2019s disease","volume":"11","author":"Kim","year":"1994","journal-title":"Pediatr Dermatol"},{"key":"2023092217013431100_R18","doi-asserted-by":"crossref","DOI":"10.1186\/s12969-017-0213-x","article-title":"A national cohort study on pediatric Beh\u00e7et\u2019s disease: cross-sectional data from an Italian registry","volume":"15","author":"Gallizzi","year":"2017","journal-title":"Pediatr Rheumatol Online J"},{"key":"2023092217013431100_R19","first-page":"2393","article-title":"Target organ associations in Turkish patients with Beh\u00e7et\u2019s disease: a cross sectional study by exploratory factor analysis","volume":"29","author":"Tunc","year":"2002","journal-title":"J Rheumatol"},{"key":"2023092217013431100_R20","article-title":"Subgroup classification of Beh\u00e7et\u2019s disease using clinical information: analysis of a clinical database of patients receiving financial aid for treatment","author":"Kurosawa","year":"2018"},{"key":"2023092217013431100_R21","first-page":"48","article-title":"Are clusters of patients with distinct clinical expression present in Beh\u00e7et\u2019s disease?","volume":"27","author":"Arida","year":"2009","journal-title":"Clin Exp Rheumatol"},{"key":"2023092217013431100_R22","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1093\/rheumatology\/ker423","article-title":"The papulopustular lesion\/arthritis cluster of Behcet\u2019s syndrome also clusters in families","volume":"51","author":"Karaca","year":"2012","journal-title":"Rheumatology (Oxford)"},{"key":"2023092217013431100_R23","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/art.23450","article-title":"Increased enthesopathy among Behcet\u2019s syndrome patients with acne and arthritis: an ultrasonography study","volume":"58","author":"Hatemi","year":"2008","journal-title":"Arthritis Rheum"},{"key":"2023092217013431100_R24","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-021-02429-7","article-title":"Cluster analysis of phenotypes of patients with Behcet\u2019s syndrome: a large cohort study from a referral center in China","volume":"23","author":"Zou","year":"2021","journal-title":"Arthritis Res Ther"},{"key":"2023092217013431100_R25","first-page":"347","article-title":"Disease patterns of patients with Behcet\u2019s disease demonstrated by factor analysis","volume":"17","author":"Krause","year":"1999","journal-title":"Clin Exp Rheumatol"},{"key":"2023092217013431100_R26","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1093\/brain\/122.11.2183","article-title":"Neurological complications in Beh\u00e7et\u2019s syndrome","volume":"122","author":"Kidd","year":"1999","journal-title":"Brain J Neurol"}],"container-title":["Modern Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mr\/advance-article-pdf\/doi\/10.1093\/mr\/roac044\/43890772\/roac044.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mr\/article-pdf\/33\/3\/574\/51715077\/roac044.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mr\/article-pdf\/33\/3\/574\/51715077\/roac044.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T17:31:16Z","timestamp":1695403876000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mr\/article\/33\/3\/574\/6582903"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,10]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,5,10]]},"published-print":{"date-parts":[[2023,4,13]]}},"URL":"https:\/\/doi.org\/10.1093\/mr\/roac044","relation":{},"ISSN":["1439-7595","1439-7609"],"issn-type":[{"value":"1439-7595","type":"print"},{"value":"1439-7609","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,5,1]]},"published":{"date-parts":[[2022,5,10]]}}}