{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T12:06:03Z","timestamp":1774958763070,"version":"3.50.1"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T00:00:00Z","timestamp":1652486400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81373209"],"award-info":[{"award-number":["81373209"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971517"],"award-info":[{"award-number":["81971517"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971534"],"award-info":[{"award-number":["81971534"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,13]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study evaluated the characteristics of serosal involvement in adult-onset Still\u2019s disease (AOSD).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients meeting the Yamaguchi classification criteria were classified into AOSD with and without serosal involvement according to their manifestations and sonography\/radiography. Clinical data was retrospectively reviewed from 102 patients with AOSD in two centres.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Forty-two patients (41.2%) had serosal involvement. The frequencies of pulmonary infiltrate and impaired liver function were significantly higher in patients with serosal involvement (p\u2009=\u2009.002 and p\u2009=\u2009.007, respectively), who also had a higher modified systemic score (p\u2009=\u2009.009). In addition, the percentages of CD3+ T cells (p\u2009&amp;lt;\u2009.001) and, especially, the CD8+ T cells (p\u2009=\u2009.004) were significantly increased in the peripheral blood of AOSD patients with serosal involvement. Notably, patients with serosal involvement were more likely to develop macrophage activation syndrome (p\u2009=\u2009.047) and a chronic pattern (p\u2009=\u2009.016) during the follow-up.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Patients with serosal involvement demonstrated the more severe disease activity and different immune phenotypes; these patients were more likely to develop macrophage activation syndrome, and they may require more aggressive treatment at an early time to control their systemic inflammation.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roac048","type":"journal-article","created":{"date-parts":[[2022,5,14]],"date-time":"2022-05-14T12:45:53Z","timestamp":1652532353000},"page":"579-587","source":"Crossref","is-referenced-by-count":2,"title":["Serosal involvement in adult-onset Still\u2019s disease: A multicentre and retrospective study"],"prefix":"10.1093","volume":"33","author":[{"given":"Yixuan","family":"Li","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruru","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjing","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School , Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuyang","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3606-3949","authenticated-orcid":false,"given":"Jia","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liangjing","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuebing","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Immunology, The Affiliated Drum Tower Hospital of Nanjing University Medical School , Nanjing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5183-1029","authenticated-orcid":false,"given":"Xiaoxiang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Renji Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,5,14]]},"reference":[{"key":"2023092217014622300_R1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3109\/07853890.2014.971052","article-title":"Adult-onset Still\u2019s disease-pathogenesis, clinical manifestations, and new treatment options","volume":"47","author":"Kadavath","year":"2015","journal-title":"Ann Med"},{"key":"2023092217014622300_R2","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jaut.2014.01.011","article-title":"Diagnosis and classification of adult Still\u2019s disease","volume":"48\u201349","author":"Mahroum","year":"2014","journal-title":"J Autoimmun"},{"key":"2023092217014622300_R3","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jaut.2018.07.018","article-title":"A comprehensive review on adult onset Still\u2019s disease","volume":"93","author":"Giacomelli","year":"2018","journal-title":"J Autoimmun"},{"key":"2023092217014622300_R4","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s10067-014-2487-4","article-title":"Life-threatening complications of adult-onset Still\u2019s disease","volume":"33","author":"Efthimiou","year":"2014","journal-title":"Clin Rheumatol"},{"key":"2023092217014622300_R5","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1007\/s10067-017-3830-3","article-title":"Macrophage activation syndrome in Still\u2019s disease: analysis of clinical characteristics and survival in paediatric and adult patients","volume":"36","author":"Ruscitti","year":"2017","journal-title":"Clin Rheumatol"},{"key":"2023092217014622300_R6","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/00005792-199103000-00004","article-title":"Adult Still\u2019s disease: manifestations, disease course, and outcome in 62 patients","volume":"70","author":"Pouchot","year":"1991","journal-title":"Medicine (Baltimore)"},{"key":"2023092217014622300_R7","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.autrev.2014.01.058","article-title":"Adult-onset Still\u2019s disease","volume":"13","author":"Gerfaud-Valentin","year":"2014","journal-title":"Autoimmun Rev"},{"key":"2023092217014622300_R8","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1080\/14397595.2020.1829340","article-title":"Clinical features of elderly-onset adult-onset Still\u2019s disease","volume":"31","author":"Maruyama","year":"2021","journal-title":"Mod Rheumatol"},{"key":"2023092217014622300_R9","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3109\/14397595.2014.974881","article-title":"Nationwide epidemiological survey of 169 patients with adult Still\u2019s disease in Japan","volume":"25","author":"Asanuma","year":"2015","journal-title":"Mod Rheumatol"},{"key":"2023092217014622300_R10","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1007\/s00296-007-0425-3","article-title":"Adult onset Still\u2019s disease flared with pericardial effusion","volume":"28","author":"Yoo","year":"2008","journal-title":"Rheumatol Int"},{"key":"2023092217014622300_R11","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1007\/s10067-015-3164-y","article-title":"A retrospective study of patients with adult-onset Still\u2019s disease: is pericarditis a possible predictor for biological disease-modifying anti-rheumatic drugs need?","volume":"35","author":"Dall\u2019Ara","year":"2016","journal-title":"Clin Rheumatol"},{"key":"2023092217014622300_R12","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1136\/ard.2005.042143","article-title":"Diagnosis and management of adult onset Still\u2019s disease","volume":"65","author":"Efthimiou","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"2023092217014622300_R13","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1080\/14397595.2018.1465633","article-title":"Evidence-based clinical practice guideline for adult Still\u2019s disease","volume":"28","author":"Mimura","year":"2018","journal-title":"Mod Rheumatol"},{"key":"2023092217014622300_R14","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1007\/s10067-010-1516-1","article-title":"Clinical features and prognosis in adult-onset Still\u2019s disease: a study of 104 cases","volume":"29","author":"Kong","year":"2010","journal-title":"Clin Rheumatol"},{"key":"2023092217014622300_R15","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.berh.2016.08.003","article-title":"Adult-onset Still\u2019s disease: advances in the treatment","volume":"30","author":"Castaneda","year":"2016","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2023092217014622300_R16","first-page":"373","article-title":"Corticosteroid sparing effect of low dose methotrexate treatment in adult Still\u2019s disease","volume":"26","author":"Fautrel","year":"1999","journal-title":"J Rheumatol"},{"key":"2023092217014622300_R17","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1136\/ard.56.2.144","article-title":"Methotrexate treatment in patients with adult onset Still\u2019s disease\u2014retrospective study of 13 Japanese cases","volume":"56","author":"Fujii","year":"1997","journal-title":"Ann Rheum Dis"},{"key":"2023092217014622300_R18","doi-asserted-by":"crossref","first-page":"57","DOI":"10.3109\/s10165-008-0126-0","article-title":"Cyclosporin A treatment for Japanese patients with severe adult-onset Still\u2019s disease","volume":"19","author":"Mitamura","year":"2009","journal-title":"Mod Rheumatol"},{"key":"2023092217014622300_R19","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.autrev.2014.08.032","article-title":"Adult onset Still\u2019s disease (AOSD) in the era of biologic therapies: dichotomous view for cytokine and clinical expressions","volume":"13","author":"Maria","year":"2014","journal-title":"Autoimmun Rev"},{"key":"2023092217014622300_R20","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1080\/1744666X.2017.1375853","article-title":"Biologic drugs in adult onset Still\u2019s disease: a systematic review and meta-analysis of observational studies","volume":"13","author":"Ruscitti","year":"2017","journal-title":"Expert Rev Clin Immunol"},{"key":"2023092217014622300_R21","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1080\/14712598.2019.1652591","article-title":"Biologics for the treatment of adult-onset still\u2019s disease","volume":"19","author":"Yoo","year":"2019","journal-title":"Expert Opin Biol Ther"},{"key":"2023092217014622300_R22","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.2169\/internalmedicine.9809-17","article-title":"Severe adult-onset Still disease with constrictive pericarditis and pleuritis that was successfully treated with tocilizumab in addition to corticosteroids and cyclosporin A","volume":"57","author":"Kawaguchi","year":"2018","journal-title":"Intern Med"},{"key":"2023092217014622300_R23","first-page":"628","article-title":"Adult-onset Still\u2019s disease with pulmonary and cardiac involvement and response to intravenous immunoglobulin","volume":"34","author":"Neto","year":"2009","journal-title":"Acta Reumatol Port"},{"key":"2023092217014622300_R24","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2020.102541","article-title":"Cardiac involvement in adult-onset Still\u2019s disease: manifestations, treatments and outcomes in a retrospective study of 28 patients","volume":"116","author":"Bodard","year":"2021","journal-title":"J Autoimmun"},{"key":"2023092217014622300_R25","first-page":"389","article-title":"A case of severe adult-onset Still\u2019s disease presenting with pleuropericarditis","volume":"44","author":"Ikeue","year":"2006","journal-title":"Nihon Kokyuki Gakkai Zasshi"},{"key":"2023092217014622300_R26","first-page":"322","article-title":"Diagnostic value of ferritin and glycosylated ferritin in adult onset Still\u2019s disease","volume":"28","author":"Fautrel","year":"2001","journal-title":"J Rheumatol"},{"key":"2023092217014622300_R27","first-page":"424","article-title":"Preliminary criteria for classification of adult Still\u2019s disease","volume":"19","author":"Yamaguchi","year":"1992","journal-title":"J Rheumatol"},{"key":"2023092217014622300_R28","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1002\/pbc.21039","article-title":"HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis","volume":"48","author":"Henter","year":"2007","journal-title":"Pediatr Blood Cancer"},{"key":"2023092217014622300_R29","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1002\/art.1780300209","article-title":"Adult-onset Still\u2019s disease. Clinical course and outcome","volume":"30","author":"Cush","year":"1987","journal-title":"Arthritis Rheum"},{"key":"2023092217014622300_R30","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1097\/CM9.0000000000000538","article-title":"Pathogenesis, disease course, and prognosis of adult-onset Still\u2019s disease: an update and review","volume":"132","author":"Wang","year":"2019","journal-title":"Chin Med J (Engl)"},{"key":"2023092217014622300_R31","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1136\/ard.30.2.121","article-title":"Still\u2019s disease in the adult","volume":"30","author":"Bywaters","year":"1971","journal-title":"Ann Rheum Dis"},{"key":"2023092217014622300_R32","doi-asserted-by":"crossref","DOI":"10.1136\/lupus-2017-000221","article-title":"Associates and predictors of pleurisy or pericarditis in SLE","volume":"4","author":"Ryu","year":"2017","journal-title":"Lupus Sci Med"},{"key":"2023092217014622300_R33","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2020-234752","article-title":"Adult-onset Still\u2019s disease in a 73-year-old Maltese man","volume":"13","author":"Borg","year":"2020","journal-title":"BMJ Case Rep"},{"key":"2023092217014622300_R34","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1016\/j.jaad.2021.02.005","article-title":"Risk of macrophage activation syndrome in adult-onset Still\u2019s disease patients with skin involvement: a retrospective cohort study","volume":"85","author":"Ding","year":"2021","journal-title":"J Am Acad Dermatol"},{"key":"2023092217014622300_R35","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1148\/radiol.2351020759","article-title":"Is infiltrate a useful term in the interpretation of chest radiographs? Physician survey results","volume":"235","author":"Patterson","year":"2005","journal-title":"Radiology"},{"key":"2023092217014622300_R36","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/0049-0172(90)90094-V","article-title":"A long-term study of interstitial lung disease in systemic lupus erythematosus","volume":"20","author":"Weinrib","year":"1990","journal-title":"Semin Arthritis Rheum"},{"key":"2023092217014622300_R37","first-page":"699","article-title":"Pneumocystis carinii pneumonia in systemic lupus erythematosus: a report of two cases","volume":"100","author":"Tsai","year":"2001","journal-title":"J Formos Med Assoc"},{"key":"2023092217014622300_R38","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.semarthrit.2003.09.006","article-title":"Pulmonary hemorrhage in systemic lupus erythematosus","volume":"33","author":"Badsha","year":"2004","journal-title":"Semin Arthritis Rheum"},{"key":"2023092217014622300_R39","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3346\/jkms.2009.24.1.155","article-title":"A case of adult-onset Still\u2019s disease complicated with diffuse alveolar hemorrhage","volume":"24","author":"Sari","year":"2009","journal-title":"J Korean Med Sci"},{"key":"2023092217014622300_R40","first-page":"23","article-title":"Adult-onset Still\u2019s disease-associated interstitial lung disease represents severe phenotype of the disease with higher rate of haemophagocytic syndrome and relapse","volume":"37","author":"Takakuwa","year":"2019","journal-title":"Clin Exp Rheumatol"},{"key":"2023092217014622300_R41","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.560744","article-title":"The role of RIPK1\/3 in adult onset Still\u2019s disease patients with liver damage: a preliminary study","volume":"11","author":"Liu","year":"2020","journal-title":"Front Immunol"},{"key":"2023092217014622300_R42","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000324309","article-title":"The role of the immunogenetic background in the development and recurrence of acute idiopathic pericarditis","volume":"118","author":"Lazaros","year":"2011","journal-title":"Cardiology"},{"key":"2023092217014622300_R43","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1093\/rheumatology\/keq397","article-title":"Markedly increased IL-18 liver expression in adult-onset Still\u2019s disease-related hepatitis","volume":"50","author":"Priori","year":"2011","journal-title":"Rheumatology (Oxford)"},{"key":"2023092217014622300_R44","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.tcm.2020.04.006","article-title":"The autoinflammatory side of recurrent pericarditis: enlightening the pathogenesis for a more rational treatment","volume":"31","author":"Lopalco","year":"2021","journal-title":"Trends Cardiovasc Med"},{"key":"2023092217014622300_R45","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/B978-0-444-63596-9.00004-9","volume-title":"Handbook of Systemic Autoimmune Diseases","author":"Ravelli","year":"2016"},{"key":"2023092217014622300_R46","doi-asserted-by":"crossref","first-page":"3986","DOI":"10.1093\/rheumatology\/keab485","article-title":"Current and emerging biological therapy in adult-onset Still\u2019s disease","volume":"60","author":"Ma","year":"2021","journal-title":"Rheumatology (Oxford)"}],"container-title":["Modern Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mr\/advance-article-pdf\/doi\/10.1093\/mr\/roac048\/43932253\/roac048.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mr\/article-pdf\/33\/3\/579\/51715128\/roac048.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mr\/article-pdf\/33\/3\/579\/51715128\/roac048.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T17:32:13Z","timestamp":1695403933000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mr\/article\/33\/3\/579\/6585908"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,14]]},"references-count":46,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2022,5,14]]},"published-print":{"date-parts":[[2023,4,13]]}},"URL":"https:\/\/doi.org\/10.1093\/mr\/roac048","relation":{},"ISSN":["1439-7595","1439-7609"],"issn-type":[{"value":"1439-7595","type":"print"},{"value":"1439-7609","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,5,1]]},"published":{"date-parts":[[2022,5,14]]}}}