{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:14:18Z","timestamp":1790082858181,"version":"4.0.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T00:00:00Z","timestamp":1654905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,13]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>This study aimed to clarify the frequency\u2013response relationship between exercise habits and locomotive syndrome (LS) in different age groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We analysed 8681 independent community dwellers who participated in a nationwide cross-sectional LS study. Participants were divided into young (20\u201339\u2009years), middle (40\u201364\u2009years), and old (\u2265\u200965\u2009years) groups. The presence of LS was evaluated using the LS risk tests. Exercise habits were assessed by exercise frequency (almost every day\/sometimes\/occasionally\/never). The association between LS and exercise was assessed using the multiple logistic regression analysis adjusted for participant characteristics for each age category.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Overall, 3528 (41%) participants had LS. In the old group, the risk of LS was lower with an increased exercise frequency. However, this dose\u2013response relationship was not found in the young group. The proportion of LS was lower even in participants who occasionally exercised (1\u20133\u2009days\/month) than those who never exercise in the young and middle age groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Regular exercise reduced the risk of LS not only in middle and older adults but also in young adults. Moreover, increasing exercise frequency may provide benefits for LS prevention, especially among older adults.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roac050","type":"journal-article","created":{"date-parts":[[2022,6,11]],"date-time":"2022-06-11T11:44:22Z","timestamp":1654947862000},"page":"617-622","source":"Crossref","is-referenced-by-count":6,"title":["Frequency\u2013response relationship between exercise and locomotive syndrome across age groups: Secondary analysis of a nationwide cross-sectional study in Japan"],"prefix":"10.1093","volume":"33","author":[{"given":"Satoshi","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Graduate School of Medical and Pharmaceutical Sciences, Chiba University , Chiba, Japan"},{"name":"Graduate School of Global and Transdisciplinary Studies, Chiba University , Chiba, Japan"},{"name":"\u201cLocomo Challenge!\u201d Promotion Council , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiko","family":"Yamada","sequence":"additional","affiliation":[{"name":"\u201cLocomo Challenge!\u201d Promotion Council , Tokyo, Japan"},{"name":"Departments of Sensory & Motor System Medicine, Faculty of Medicine, The University of Tokyo , Tokyo, Japan"},{"name":"Department of Planning, Information and Management, University of Tokyo Hospital , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoichi M","family":"Ito","sequence":"additional","affiliation":[{"name":"Data Science Center, Promotion Unit, Institute of Health Science Innovation for Medical Care, Hokkaido University Hospital , Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Fuji","sequence":"additional","affiliation":[{"name":"\u201cLocomo Challenge!\u201d Promotion Council , Tokyo, Japan"},{"name":"Department of Orthopaedic Surgery, North Osaka Housenka Hospital , Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimihito","family":"Sato","sequence":"additional","affiliation":[{"name":"\u201cLocomo Challenge!\u201d Promotion Council , Tokyo, Japan"},{"name":"Sato Orthopaedic Clinic , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Ohe","sequence":"additional","affiliation":[{"name":"\u201cLocomo Challenge!\u201d Promotion Council , Tokyo, Japan"},{"name":"Department of Orthopaedic Surgery, NTT Medical Center , Tokyo, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,6,11]]},"reference":[{"key":"2023092217012925200_R1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s12018-016-9208-2","article-title":"Locomotive syndrome: definition and management","volume":"14","author":"Nakamura","year":"2016","journal-title":"Clin Rev Bone Miner 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