{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:41:57Z","timestamp":1740109317161,"version":"3.37.3"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T00:00:00Z","timestamp":1656979200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Persistence with treatment is key to achieving successful treatment outcomes in patients with osteoporosis. We investigated risk factors for denosumab discontinuation in patients with postmenopausal osteoporosis (PMO).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 333 patients with PMO who had never received osteoporosis treatment were included in this study. Baseline demographics and retention rate of denosumab were evaluated in all patients. Univariate analysis was performed in patients divided into two groups according to whether they had continued or discontinued denosumab. A Cox proportional hazards model was used to determine risk factors for denosumab discontinuation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The mean age was 80.7\u2009years, the body mass index (BMI) was 21.5\u2009kg\/m2, and T-scores for the lumbar spine and femoral neck were \u22122.7 and \u22122.8, respectively. The retention rate of denosumab at 36\u2009months was 50.3%. Patients who continued denosumab were younger and had higher BMI, serum albumin (Alb) levels, lumbar spine bone mineral density, and fewer vertebral fractures (VFs), compared with those who discontinued denosumab. The Cox proportional hazards model revealed that a low BMI, low serum Alb levels, and a high number of VFs are independent risk factors for denosumab discontinuation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>A low BMI, low serum Alb levels, and a high number of VFs were associated with denosumab discontinuation in patients with PMO.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roac070","type":"journal-article","created":{"date-parts":[[2022,7,5]],"date-time":"2022-07-05T12:26:48Z","timestamp":1657024008000},"page":"843-850","source":"Crossref","is-referenced-by-count":2,"title":["Risk factors for denosumab discontinuation in patients with postmenopausal osteoporosis"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2465-1281","authenticated-orcid":false,"given":"Kyosuke","family":"Hattori","sequence":"first","affiliation":[{"name":"Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine , Nagoya, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobunori","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine , Nagoya, Aichi, Japan"},{"name":"Orthopedic Surgery, Aichi Medical University , Nagakute, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihisa","family":"Kojima","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine , Nagoya, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6951-8575","authenticated-orcid":false,"given":"Shiro","family":"Imagama","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery and Rheumatology, Nagoya University Graduate School of Medicine , Nagoya, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,7,5]]},"reference":[{"key":"2023070502120345400_R1","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","article-title":"Osteoporosis: now and the future","volume":"377","author":"Rachner","year":"2011","journal-title":"Lancet"},{"key":"2023070502120345400_R2","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.69","article-title":"Postmenopausal osteoporosis","volume":"2","author":"Eastell","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"2023070502120345400_R3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4158\/EP161435.GL","article-title":"American Association of Clinical Endocrinologists and American College of Endocrinology Clinical Practice Guidelines for the diagnosis and treatment of postmenopausal osteoporosis - 2016","volume":"22","author":"Camacho","year":"2016","journal-title":"Endocr Pract"},{"key":"2023070502120345400_R4","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/jbmr.1476","article-title":"Previous fractures at multiple sites increase the risk for subsequent fractures: the global longitudinal study of osteoporosis in women","volume":"27","author":"Gehlbach","year":"2012","journal-title":"J Bone Miner Res"},{"key":"2023070502120345400_R5","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1210\/jc.2013-3461","article-title":"The impact of nonhip nonvertebral fractures in elderly women and men","volume":"99","author":"Bliuc","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"2023070502120345400_R6","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1177\/230949901001800204","article-title":"Mortality after vertebral fractures in a Japanese population","volume":"18","author":"Ikeda","year":"2010","journal-title":"J Orthop Surg (Hong Kong)"},{"key":"2023070502120345400_R7","doi-asserted-by":"crossref","first-page":"2479","DOI":"10.1007\/s00198-015-3164-4","article-title":"Persistence, adherence, and medication-taking behavior in women with postmenopausal osteoporosis receiving denosumab in routine practice in Germany, Austria, Greece, and Belgium: 12-month results from a European non-interventional study","volume":"26","author":"Hadji","year":"2015","journal-title":"Osteoporos Int"},{"key":"2023070502120345400_R8","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1056\/NEJMoa0809493","article-title":"Denosumab for prevention of fractures in postmenopausal women with osteoporosis","volume":"361","author":"Cummings","year":"2009","journal-title":"N Engl J Med"},{"key":"2023070502120345400_R9","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S2213-8587(17)30138-9","article-title":"10 years of denosumab treatment in postmenopausal women with osteoporosis: results from the phase 3 randomised FREEDOM trial and open-label extension","volume":"5","author":"Bone","year":"2017","journal-title":"Lancet Diabetes Endocrinol"},{"key":"2023070502120345400_R10","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bone.2017.08.003","article-title":"Discontinuation of denosumab therapy for osteoporosis: a systematic review and position statement by ECTS","volume":"105","author":"Tsourdi","year":"2017","journal-title":"Bone"},{"key":"2023070502120345400_R11","article-title":"Predictive factors for achievement of treatment goals in patients with postmenopausal osteoporosis treated with denosumab","author":"Hattori","year":"2021","journal-title":"Mod Rheumatol"},{"key":"2023070502120345400_R12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s11657-012-0109-9","article-title":"Japanese 2011 guidelines for prevention and treatment of osteoporosis\u2014executive summary","volume":"7","author":"Orimo","year":"2012","journal-title":"Arch Osteoporos"},{"key":"2023070502120345400_R13","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1007\/s001980170062","article-title":"Risk factors for osteoporosis related to their outcome: fractures","volume":"12","author":"van der Voort","year":"2001","journal-title":"Osteoporos Int"},{"key":"2023070502120345400_R14","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s001980070048","article-title":"In elderly women weight is the best predictor of a very low bone mineral density: evidence from the EPIDOS study","volume":"11","author":"Dargent-Molina","year":"2000","journal-title":"Osteoporos Int"},{"key":"2023070502120345400_R15","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1056\/NEJM199503233321202","article-title":"Risk factors for hip fracture in white women. Study of Osteoporotic Fractures Research Group","volume":"332","author":"Cummings","year":"1995","journal-title":"N Engl J Med"},{"key":"2023070502120345400_R16","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1210\/jc.2016-1099","article-title":"Association of hypoalbuminemia with osteoporosis: analysis of the national health and nutrition examination survey","volume":"101","author":"Afshinnia","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"2023070502120345400_R17","article-title":"Low serum albumin concentration is associated with increased risk of osteoporosis in postmenopausal patients with rheumatoid arthritis","author":"Nagayama","year":"2021","journal-title":"J Orthop Sci"},{"key":"2023070502120345400_R18","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1007\/s00296-012-2663-2","article-title":"Improved real-life adherence of 6-monthly denosumab injections due to positive feedback based on rapid 6-month BMD increase and good safety profile","volume":"34","author":"Ringe","year":"2014","journal-title":"Rheumatol Int"},{"key":"2023070502120345400_R19","first-page":"824","article-title":"Persistance and compliance with osteroporosis therapies among women in a commercially insured population in the United States","volume":"21","author":"Cheng","year":"2015","journal-title":"J Manag Care Spec Pharm"},{"key":"2023070502120345400_R20","doi-asserted-by":"crossref","DOI":"10.1007\/s11657-017-0316-5","article-title":"Two-year persistence and compliance with osteoporosis therapies among postmenopausal women in a commercially insured population in the United States","volume":"12","author":"Durden","year":"2017","journal-title":"Arch Osteoporos"},{"key":"2023070502120345400_R21","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1007\/s00198-015-3253-4","article-title":"Persistence with denosumab and persistence with oral bisphosphonates for the treatment of postmenopausal osteoporosis: a retrospective, observational study, and a meta-analysis","volume":"26","author":"Karlsson","year":"2015","journal-title":"Osteoporos Int"},{"key":"2023070502120345400_R22","doi-asserted-by":"crossref","first-page":"2967","DOI":"10.1007\/s00198-016-3623-6","article-title":"GRAND-4: the German retrospective analysis of long-term persistence in women with osteoporosis treated with bisphosphonates or denosumab","volume":"27","author":"Hadji","year":"2016","journal-title":"Osteoporos Int"},{"key":"2023070502120345400_R23","first-page":"24","article-title":"Body mass index and its relationship with disability, chronic diseases and frailty in older people: a comparison of the lipschitz and who classifications","volume":"6","author":"Pessanha","year":"2017","journal-title":"J Frailty Aging"},{"key":"2023070502120345400_R24","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1111\/1556-4029.13058","article-title":"Incidence of low body mass index in the elderly in forensic cases-a possible marker for frailty syndrome?","volume":"61","author":"Byard","year":"2016","journal-title":"J Forensic Sci"},{"key":"2023070502120345400_R25","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/gerona\/glp186","article-title":"Frailty, body mass index, and abdominal obesity in older people","volume":"65","author":"Hubbard","year":"2010","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2023070502120345400_R26","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.archger.2017.03.008","article-title":"Body composition and frailty profiles in Brazilian older people: Frailty in Brazilian Older People Study-FIBRA-BR","volume":"71","author":"Ferriolli","year":"2017","journal-title":"Arch Gerontol Geriatr"},{"key":"2023070502120345400_R27","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1016\/j.clnu.2013.05.007","article-title":"Prevalence and determinants for malnutrition in geriatric outpatients","volume":"32","author":"van Bokhorst-de van der Schueren","year":"2013","journal-title":"Clin Nutr"},{"key":"2023070502120345400_R28","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1111\/j.1532-5415.2007.01549.x","article-title":"Lower levels of serum albumin and total cholesterol associated with decline in activities of daily living and excess mortality in a 12-year cohort study of elderly Japanese","volume":"56","author":"Okamura","year":"2008","journal-title":"J Am Geriatr Soc"},{"key":"2023070502120345400_R29","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jos.2020.02.006","article-title":"Predictors of dropout from cohort study due to deterioration in health status, with focus on sarcopenia, locomotive syndrome, and frailty: from the Shiraniwa Elderly Cohort (Shiraniwa) study","volume":"26","author":"Ohyama","year":"2021","journal-title":"J Orthop Sci"},{"key":"2023070502120345400_R30","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jclinepi.2004.05.006","article-title":"A systematic literature review of attrition between waves in longitudinal studies in the elderly shows a consistent pattern of dropout between differing studies","volume":"58","author":"Chatfield","year":"2005","journal-title":"J Clin Epidemiol"},{"key":"2023070502120345400_R31","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1111\/jgs.14834","article-title":"Determinants of dropout and nonadherence in a dementia prevention randomized controlled trial: the prevention of dementia by intensive vascular care trial","volume":"65","author":"Beishuizen","year":"2017","journal-title":"J Am Geriatr Soc"},{"key":"2023070502120345400_R32","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.archger.2011.04.019","article-title":"Which body mass index (BMI) is better in the elderly for functional status?","volume":"54","author":"Bahat","year":"2012","journal-title":"Arch Gerontol Geriatr"},{"key":"2023070502120345400_R33","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s00394-019-01978-7","article-title":"Higher protein intake is associated with a lower likelihood of frailty among older women, Kuopio OSTPRE-Fracture Prevention Study","volume":"59","author":"Isanejad","year":"2020","journal-title":"Eur J Nutr"},{"key":"2023070502120345400_R34","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1093\/gerona\/gls229","article-title":"Is the optimal level of protein intake for older adults greater than the recommended dietary allowance?","volume":"68","author":"Volpi","year":"2013","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2023070502120345400_R35","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1001\/archinte.1996.00440200087011","article-title":"Vertebral fracture and other predictors of physical impairment and health care utilization","volume":"156","author":"Huang","year":"1996","journal-title":"Arch Intern Med"},{"key":"2023070502120345400_R36","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1007\/s001980200099","article-title":"Prevalence of vertebral deformity and its associations with physical impairment among Japanese women: the Hizen-Oshima Study","volume":"13","author":"Jinbayashi","year":"2002","journal-title":"Osteoporos Int"},{"key":"2023070502120345400_R37","doi-asserted-by":"crossref","DOI":"10.1186\/s12891-017-1531-3","article-title":"Association of vertebral compression fractures with physical performance measures among community-dwelling Japanese women aged 40 years and older","volume":"18","author":"Arima","year":"2017","journal-title":"BMC Musculoskelet Disord"},{"key":"2023070502120345400_R38","doi-asserted-by":"crossref","DOI":"10.1007\/s11657-021-01000-w","article-title":"Discontinuation of bisphosphonates in seniors: a systematic review on health outcomes","volume":"16","author":"Lamarre","year":"2021","journal-title":"Arch Osteoporos"}],"container-title":["Modern Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mr\/advance-article-pdf\/doi\/10.1093\/mr\/roac070\/44962385\/roac070.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mr\/article-pdf\/33\/4\/843\/50797240\/roac070.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mr\/article-pdf\/33\/4\/843\/50797240\/roac070.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,7,5]],"date-time":"2023-07-05T03:04:02Z","timestamp":1688526242000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mr\/article\/33\/4\/843\/6631070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,5]]},"references-count":38,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2022,7,5]]},"published-print":{"date-parts":[[2023,7,4]]}},"URL":"https:\/\/doi.org\/10.1093\/mr\/roac070","relation":{},"ISSN":["1439-7595","1439-7609"],"issn-type":[{"type":"print","value":"1439-7595"},{"type":"electronic","value":"1439-7609"}],"subject":[],"published-other":{"date-parts":[[2023,7,1]]},"published":{"date-parts":[[2022,7,5]]}}}