{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T14:34:19Z","timestamp":1771684459313,"version":"3.50.1"},"reference-count":26,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To evaluate the impact of familial Mediterranean fever (FMF) features on the clinical course and outcomes of coronavirus disease 2019 (COVID-19) and clinical course of FMF after COVID-19.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Consecutive FMF patients with COVID-19 were enrolled from three referral hospitals. Clinical features of FMF and detailed COVID-19 information were obtained from patient interviews and medical records.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Seventy-three FMF patients were included in the study. 94.5% of patients had clinical symptoms of COVID-19. We found 24.7% hospitalization, 12.3% respiratory support, 4.1% intensive care unit admission, 6.8% complication, and 1.4% mortality rate in patients. The risk factors of hospitalization for respiratory support were male gender [OR: 7.167 (95% CI: 1.368\u201337.535)], greater age [OR: 1.067 (95% CI: 1.016\u20131.121)], and non-adherence to colchicine treatment before the infection [OR: 7.5 (95% CI: 1.348\u201341.722)]. One-third of patients had reported attacks after COVID-19. The patterns of triggered attacks were fever, peritonitis, pleuritis, transient arthritis, chronic knee mono-arthritis, and protracted febrile myalgia.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>FMF characteristics were not associated with worse outcomes of COVID-19. Colchicine non-adherence was the risk factor of hospitalization for oxygen support. The rate of FMF attacks after COVID-19 is prominently increased, with some of them being protracted and destructive.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roac074","type":"journal-article","created":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T08:08:59Z","timestamp":1658390939000},"page":"786-791","source":"Crossref","is-referenced-by-count":4,"title":["COVID-19 in familial Mediterranean fever: Clinical course and complications related to primary disease"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9866-9797","authenticated-orcid":false,"given":"Aslihan","family":"Avanoglu Guler","sequence":"first","affiliation":[{"name":"Faculty of Medicine Hospital, Department of Rheumatology , Gazi University, Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9026-9641","authenticated-orcid":false,"given":"Tuba","family":"Yuce Inel","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Hospital, Department of Rheumatology, Dokuz Eylul University , Izmir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Timucin","family":"Kasifoglu","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Hospital, Department of Rheumatology, Eskisehir Osmangazi University , Eskisehir, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cansu","family":"Coskun","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Hospital, Department of Internal Medicine, Gazi University , Ankara, Tukey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hazan","family":"Karadeniz","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Hospital, Department of Rheumatology , Gazi University, Ankara, 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