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However, recent advances in imaging modalities have indicated frequent association of tenosynovitis with RA, and some consider tenosynovitis to be not just a complication but a major trait of RA. Furthermore, as there are cases with tenosynovitis preceding the clinical detection of inflammatory arthritis in predisposed individuals, tenosynovitis may constitute an important biomarker in defining the pre-RA phase of disease development. Tenosynovitis itself must be treated as it causes functional impairment and physical as well as socioeconomic burden, and its treatment may result in effective prevention of RA development at a pre-arthritic stage. Thus, further efforts need to be taken in detecting and treating tenosynovitis in the pre-RA stage, which can be facilitated by ultrasonography and magnetic resonance imaging.<\/jats:p>","DOI":"10.1093\/mr\/roac109","type":"journal-article","created":{"date-parts":[[2022,9,20]],"date-time":"2022-09-20T10:14:39Z","timestamp":1663668879000},"page":"868-874","source":"Crossref","is-referenced-by-count":4,"title":["Importance of tenosynovitis in preventing the progression through rheumatoid arthritis continuum"],"prefix":"10.1093","volume":"33","author":[{"given":"Tomomasa","family":"Izumiyama","sequence":"first","affiliation":[{"name":"Higashisendai Rheumatic Disease Clinic , Sendai, Miyagi, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaaki","family":"Miyazawa","sequence":"additional","affiliation":[{"name":"Department of Immunology, Kindai University Faculty of Medicine , Osaka-Sayama, Osaka, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,9,19]]},"reference":[{"key":"2023082610104980900_R1","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1136\/ard.2010.138461","article-title":"2010 rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative","volume":"69","author":"Aletaha","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"2023082610104980900_R2","doi-asserted-by":"publisher","first-page":"2338","DOI":"10.1016\/S0140-6736(17)31491-5","article-title":"Targeted treatments for rheumatoid arthritis 2: novel treatment strategies in rheumatoid arthritis","volume":"389","author":"Burmester","year":"2017","journal-title":"Lancet"},{"key":"2023082610104980900_R3","doi-asserted-by":"publisher","first-page":"521","DOI":"10.1038\/nrrheum.2014.82","article-title":"Defining populations at risk of rheumatoid arthritis: the first steps to prevention","volume":"10","author":"Hunt","year":"2014","journal-title":"Nat Rev Rheumatol"},{"key":"2023082610104980900_R4","doi-asserted-by":"publisher","first-page":"546","DOI":"10.1136\/annrheumdis-2019-216350","article-title":"Not only synovitis but also tenosynovitis needs to be considered: why it is time to update textbook images of rheumatoid arthritis","volume":"79","author":"Rogier","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"2023082610104980900_R5","doi-asserted-by":"publisher","first-page":"1286","DOI":"10.1136\/annrheumdis-2021-220884","article-title":"EULAR points to consider for conducting clinical trials and observational studies in individuals at risk of rheumatoid arthritis","volume":"80","author":"Mankia","year":"2021","journal-title":"Ann Rheum Dis"},{"key":"2023082610104980900_R6","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1002\/art.23016","article-title":"Finger tendon disease in untreated early rheumatoid arthritis: a comparison of ultrasound and magnetic resonance imaging","volume":"57","author":"Wakefield","year":"2007","journal-title":"Arthritis Rheum"},{"key":"2023082610104980900_R7","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1302\/0301-620X.39B2.288","article-title":"Rheumatoid arthritis presenting as tenosynovitis","volume":"39-B","author":"Jacobs","year":"1957","journal-title":"J Bone Joint Surg"},{"key":"2023082610104980900_R8","doi-asserted-by":"publisher","first-page":"236","DOI":"10.1136\/ard.30.3.236","article-title":"Tendon involvement in the rheumatoid hand","volume":"30","author":"Backhouse","year":"1971","journal-title":"Ann Rheum Dis"},{"key":"2023082610104980900_R9","doi-asserted-by":"publisher","first-page":"1003","DOI":"10.1002\/art.1780200414","article-title":"Hand flexor tenosynovitis in rheumatoid arthritis. 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