{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T18:39:39Z","timestamp":1775068779960,"version":"3.50.1"},"reference-count":43,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T00:00:00Z","timestamp":1663286400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,25]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>The aim of this multi-centre retrospective study was to clarify the prognostic factors for respiratory-related death in patients with interstitial lung disease (ILD) complicated rheumatoid arthritis (RA). Patient background data, treatment regimen, and disease activity indicators of RA and ILD at baseline, 6\u2009months after the diagnosis of ILD, and at the last follow-up visit were extracted. A total of 312 patients with RA-ILD (17 patients who died from respiratory-related causes and 295 survivors) were included. Patients who died from respiratory-related causes had an older median age, a higher proportion of being male, and a higher anti-cyclic citrullinated peptide antibody positivity rate than survivors (p\u2009=\u2009.0001, .038, and .016, respectively); they also had significantly higher baseline serum levels of Krebs von den Lungen-6 (KL-6) than survivors (p\u2009=\u2009.013). Patients who died from respiratory-related causes showed significantly greater changes in serum KL-6 levels between the 6-month time point and the last visit [\u0394KL-6 (6\u2009months\u00a0\u2212\u00a0last)] than survivors (p\u2009=\u2009.011). Multivariate analysis showed that the \u0394KL-6 (6\u2009months\u00a0\u2212\u00a0last) corrected by disease duration was a predictor of respiratory-disease-related death in patients with RA-ILD (p\u00a0&amp;lt;\u00a0.0001). Long-term increase in serum KL-6 levels is associated with respiratory-disease related death in patients with RA-ILD.<\/jats:p>","DOI":"10.1093\/mr\/roac115","type":"journal-article","created":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T16:19:47Z","timestamp":1663345187000},"page":"928-935","source":"Crossref","is-referenced-by-count":7,"title":["Prognostic factors affecting respiratory-related death in patients with rheumatoid arthritis complicated by interstitial lung disease: An ANSWER cohort study"],"prefix":"10.1093","volume":"33","author":[{"given":"Hidehiko","family":"Makino","sequence":"first","affiliation":[{"name":"Department of Internal Medicine (IV), Osaka Medical and Pharmaceutical University , Osaka, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takuya","family":"Kotani","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine (IV), Osaka Medical and Pharmaceutical University , Osaka, 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