{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T01:37:12Z","timestamp":1776217032287,"version":"3.50.1"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T00:00:00Z","timestamp":1664755200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,8,25]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Pulmonary nontuberculous mycobacterial disease (pNTM) is a common pulmonary complication of rheumatoid arthritis (RA), but their association has rarely been researched. We aimed to reveal the clinical characteristics of RA with pNTM.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Among all the RA patients who visited Tenri hospital from April 2017 to March 2018, we enrolled those fulfilling the 2007 ATS\/IDSA diagnostic criteria of pNTM, and sex- and age- matched control group at a ratio of 1:5. Demographic characteristics were compared between the two groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 865 RA patients, 35 (4.0%) patients were complicated with pNTM. RA patients with pNTM had significantly lower BMI and higher rheumatoid factor (RF) and anti-citrullinated protein antibody (ACPA) positivity. Bronchiectasis was the most frequent lesion, followed by clusters of small nodules, patchy consolidation and cavity. Multivariable logistic regression analysis revealed bronchiectasis as a strong independent associated factor of pNTM. Treatment for pNTM was needed in 14 of the 35 (40%) RA patients with pNTM and sputum negative conversion was accomplished in 11 of the 14 cases (78.6%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>RA patients with lower BMI, RF\/ACPA positivity, and bronchiectasis were associated with pNTM. Treatment for pNTM may attain sputum negative conversion and radiological improvement in patients with RA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roac117","type":"journal-article","created":{"date-parts":[[2022,10,3]],"date-time":"2022-10-03T15:52:09Z","timestamp":1664812329000},"page":"936-943","source":"Crossref","is-referenced-by-count":2,"title":["Clinical characteristics of rheumatoid arthritis patients complicated with pulmonary nontuberculous mycobacterial disease: A cross-sectional case series study"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8130-4350","authenticated-orcid":false,"given":"Yoichi","family":"Nakayama","sequence":"first","affiliation":[{"name":"Department of General Internal Medicine, Tenri Hospital , Nara, Japan"},{"name":"Department of Rheumatology and Clinical Immunology, Kyoto University Graduate School of Medicine , Kyoto, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eisaku","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Tenri Hospital , Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakuni","family":"Ueyama","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Tenri Hospital , Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Terada","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Tenri Hospital , Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Inao","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Tenri Hospital , Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yusuke","family":"Kaji","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Tenri Hospital , Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takehiro","family":"Yasuda","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Tenri Hospital , Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seishu","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Tenri Hospital , Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Hajiro","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Tenri Hospital , Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Hatta","sequence":"additional","affiliation":[{"name":"Department of General Internal Medicine, Tenri Hospital , Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Noma","sequence":"additional","affiliation":[{"name":"Department of Radiology, Tenri Hospital , Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshio","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Tenri Hospital , Nara, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,10,3]]},"reference":[{"key":"2023082610105318400_R1","doi-asserted-by":"crossref","first-page":"1544","DOI":"10.1002\/art.40574","article-title":"The lung in rheumatoid arthritis: focus on interstitial lung disease","volume":"70","author":"Spagnolo","year":"2018","journal-title":"Arthritis Rheum"},{"key":"2023082610105318400_R2","doi-asserted-by":"crossref","first-page":"2585","DOI":"10.1007\/s10067-016-3357-z","article-title":"Risk of serious infection in patients with rheumatoid 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