{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:42:06Z","timestamp":1740109326791,"version":"3.37.3"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T00:00:00Z","timestamp":1665446400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,11,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We aimed to identify associations between patterns of large-vessel lesions of large-vessel giant cell arteritis (LV-GCA) and treatment outcomes.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We extracted data on 68 newly diagnosed patients with LV-GCA from a retrospective, multi-centric, nationwide registry of GCA patients treated with glucocorticoids between 2007 and 2014. Patients with aortic lesions were identified based on the findings from contrast-enhanced computed tomography, magnetic resonance imaging, or positron emission tomography\u2013computed tomography (Group 2, n\u2009=\u200949). Patients without aortic lesions were subdivided into LV-GCA with or without subclavian lesions defined as Group 1 (n\u2009=\u20099) or Group 3 (n\u2009=\u200910), respectively. The primary outcome evaluation was failure to achieve clinical remission by Week 24 and\/or relapse within 104\u2009weeks.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The mean age and proportion of patients with cranial lesions and polymyalgia rheumatica in Group 2 were numerically lower than in the other two groups. Large-vessel lesions in Group 3 included carotid, pulmonary, renal, hepatic, or mesenteric lesions. The cumulative rate of poor treatment outcomes &amp;gt;2\u2009years was 11.1%, 55.3%, and 88.0% in Groups 1, 2, and 3, respectively (by Kaplan\u2013Meier analysis). The mean time to poor outcome was significantly different between the groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Classification by subclavian and aortic lesions may be useful to determine treatment strategy.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roac122","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T13:50:52Z","timestamp":1665496252000},"page":"1145-1153","source":"Crossref","is-referenced-by-count":3,"title":["Association between the patterns of large-vessel lesions and treatment outcomes in patients with large-vessel giant cell arteritis"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7181-7494","authenticated-orcid":false,"given":"Takahiko","family":"Sugihara","sequence":"first","affiliation":[{"name":"Department of Lifetime Clinical Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University , Tokyo,","place":["Japan"]},{"name":"Department of Medicine and Rheumatology, Tokyo Metropolitan Geriatric Hospital , Tokyo,","place":["Japan"]},{"name":"Department of Internal Medicine, Division of Rheumatologyand Allergology, St. Marianna University Faculty of Medicine , Kawasaki,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haruhito A","family":"Uchida","sequence":"additional","affiliation":[{"name":"Department of Chronic Kidney Disease and Cardiovascular Disease, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hajime","family":"Yoshifuji","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University , Kyoto,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Maejima","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Tokyo Medical and Dental University , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taio","family":"Naniwa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, Nagoya City University Hospital , Nagoya,","place":["Japan"]},{"name":"Department of Respiratory Medicine, Allergy and Clinical Immunology, Nagoya City University Graduate School of Medical Sciences , Nagoya,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Katsumata","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, Tokyo Women\u2019s Medical University School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Okazaki","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatologyand Allergology, St. Marianna University Faculty of Medicine , Kawasaki,","place":["Japan"]},{"name":"National Hospital Organization, Shizuoka Medical Center , Shimizu,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Ishizaki","sequence":"additional","affiliation":[{"name":"Department of Hematology, Clinical Immunology and Infectious Diseases, Ehime University Graduate School of Medicine , Ehime,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohko","family":"Murakawa","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Shimane University Faculty of Medicine , Izumo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyoshi","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine 3, Hamamatsu University School of Medicine , Hamamatsu,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Dobashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Hematology, Rheumatology and Respiratory Medicine, Faculty of Medicine, Kagawa University , Kagawa,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuya","family":"Horita","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Endocrinology and Nephrology, Hokkaido University Graduate School of Medicine , Sapporo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiya","family":"Tanaka","sequence":"additional","affiliation":[{"name":"The First Department of Internal Medicine, University of Occupational and Environmental Health , Japan, Kitakyushu,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Furuta","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, Chiba University Hospital , Chiba,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, Keio University School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Komagata","sequence":"additional","affiliation":[{"name":"First Department of Internal Medicine, Kyorin University School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshikazu","family":"Nakaoka","sequence":"additional","affiliation":[{"name":"Department of Vascular Physiology, National Cerebral and Cardiovascular Center Research Institute , Suita,","place":["Japan"]},{"name":"Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine , Suita,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayoshi","family":"Harigai","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Rheumatology, Tokyo Women\u2019s Medical University School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,10,11]]},"reference":[{"key":"2024101109362547400_R1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1002\/1529-0131(199902)42:2<311::AID-ANR14>3.0.CO;2-F","article-title":"Disease pattern in cranial and large-vessel giant cell arteritis","volume":"42","author":"Brack","year":"1999","journal-title":"Arthritis Rheum"},{"key":"2024101109362547400_R2","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1136\/annrheumdis-2013-203322","article-title":"Prospective long term follow-up of a cohort of patients with giant cell arteritis screened for aortic structural damage (aneurysm or dilatation)","volume":"73","author":"Garcia-Martinez","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"2024101109362547400_R3","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1002\/art.23315","article-title":"Development of aortic aneurysm\/dilatation during the followup of patients with giant cell arteritis: a cross-sectional screening of fifty-four prospectively followed patients","volume":"59","author":"Garcia-Martinez","year":"2008","journal-title":"Arthritis Rheum"},{"key":"2024101109362547400_R4","doi-asserted-by":"crossref","first-page":"3532","DOI":"10.1002\/art.11480","article-title":"Mortality of large-artery complication (aortic aneurysm, aortic dissection, and\/or large-artery stenosis) in patients with giant cell arteritis: a population-based study over 50 years","volume":"48","author":"Nuenninghoff","year":"2003","journal-title":"Arthritis Rheum"},{"key":"2024101109362547400_R5","doi-asserted-by":"crossref","first-page":"1989","DOI":"10.1136\/annrheumdis-2012-202408","article-title":"Large-vessel involvement in giant cell arteritis: a population-based cohort study of the incidence-trends and prognosis","volume":"72","author":"Kermani","year":"2013","journal-title":"Ann Rheum Dis"},{"key":"2024101109362547400_R6","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/art.1780371020","article-title":"Thoracic aortic aneurysm and rupture in giant cell arteritis. A descriptive study of 41 cases","volume":"37","author":"Evans","year":"1994","journal-title":"Arthritis Rheum"},{"key":"2024101109362547400_R7","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1002\/art.11353","article-title":"Incidence and predictors of large-artery complication (aortic aneurysm, aortic dissection, and\/or large-artery stenosis) in patients with giant cell arteritis: a population-based study over 50 years","volume":"48","author":"Nuenninghoff","year":"2003","journal-title":"Arthritis Rheum"},{"key":"2024101109362547400_R8","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1097\/RHU.0000000000000381","article-title":"Predictors of dissection in aortic aneurysms from giant cell arteritis","volume":"22","author":"Kermani","year":"2016","journal-title":"J Clin Rheumatol"},{"key":"2024101109362547400_R9","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.autrev.2017.11.029","article-title":"Large-vessel involvement and aortic dilation in giant-cell arteritis. A multicenter study of 549 patients","volume":"17","author":"de Boysson","year":"2018","journal-title":"Autoimmun Rev"},{"key":"2024101109362547400_R10","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1002\/acr.24055","article-title":"Patterns of arterial disease in Takayasu arteritis and giant cell arteritis","volume":"72","author":"Gribbons","year":"2020","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"2024101109362547400_R11","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1136\/annrheumdis-2019-215672","article-title":"2018 Update of the EULAR recommendations for the management of large vessel vasculitis","volume":"79","author":"Hellmich","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"2024101109362547400_R12","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1253\/circj.CJ-19-0773","article-title":"JCS 2017 guideline on management of vasculitis syndrome \u2013 digest version","volume":"84","author":"Isobe","year":"2020","journal-title":"Circ J"},{"key":"2024101109362547400_R13","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1093\/rheumatology\/kez672","article-title":"British Society for Rheumatology guideline on diagnosis and treatment of giant cell arteritis","volume":"59","author":"Mackie","year":"2020","journal-title":"Rheumatology (Oxford)"},{"key":"2024101109362547400_R14","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.semarthrit.2016.11.006","article-title":"Serious adverse effects associated with glucocorticoid therapy in patients with giant cell arteritis (GCA): a nested case-control analysis","volume":"46","author":"Wilson","year":"2017","journal-title":"Semin Arthritis Rheum"},{"key":"2024101109362547400_R15","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1002\/art.11388","article-title":"Glucocorticoid therapy in giant cell arteritis: duration and adverse outcomes","volume":"49","author":"Proven","year":"2003","journal-title":"Arthritis Rheum"},{"key":"2024101109362547400_R16","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2017-000521","article-title":"Association between glucocorticoid therapy and incidence of diabetes mellitus in polymyalgia rheumatica and giant cell arteritis: a systematic review and meta-analysis","volume":"4","author":"Lai","year":"2018","journal-title":"RMD Open"},{"key":"2024101109362547400_R17","doi-asserted-by":"crossref","first-page":"5080","DOI":"10.1093\/rheumatology\/keab222","article-title":"Real-life analysis of the causes of death in patients consecutively followed for giant cell arteritis in a French centre of expertise","volume":"60","author":"Antonini","year":"2021","journal-title":"Rheumatology (Oxford)"},{"key":"2024101109362547400_R18","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/acr.24632","article-title":"2021 American College of Rheumatology\/Vasculitis Foundation Guideline for the management of giant cell arteritis and Takayasu arteritis","volume":"73","author":"Maz","year":"2021","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"2024101109362547400_R19","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/14397595.2018.1546358","article-title":"Pathophysiology of large vessel vasculitis and utility of interleukin-6 inhibition therapy","volume":"29","author":"Yoshifuji","year":"2019","journal-title":"Mod Rheumatol"},{"key":"2024101109362547400_R20","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-020-02171-6","article-title":"Associated factors of poor treatment outcomes in patients with giant cell arteritis: clinical implication of large vessel lesions","volume":"22","author":"Sugihara","year":"2020","journal-title":"Arthritis Res Ther"},{"key":"2024101109362547400_R21","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1093\/rheumatology\/keu329","article-title":"Large-vessel giant cell arteritis: a cohort study","volume":"54","author":"Muratore","year":"2015","journal-title":"Rheumatology (Oxford)"},{"key":"2024101109362547400_R22","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1056\/NEJMoa1613849","article-title":"Trial of tocilizumab in giant-cell arteritis","volume":"377","author":"Stone","year":"2017","journal-title":"N Engl J Med"},{"key":"2024101109362547400_R23","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000003851","article-title":"18F-fluorodeoxyglucose positron emission tomography and the risk of subsequent aortic complications in giant-cell arteritis: a multicenter cohort of 130 patients","volume":"95","author":"de Boysson","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"2024101109362547400_R24","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.semarthrit.2021.03.001","article-title":"Giant cell arteritis-related aortic dissection: a multicenter retrospective study","volume":"51","author":"de Boysson","year":"2021","journal-title":"Semin Arthritis Rheum"},{"key":"2024101109362547400_R25","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1093\/rheumatology\/key028","article-title":"Mortality causes and trends associated with giant cell arteritis: analysis of the French national death certificate database (1980-2011)","volume":"57","author":"Aouba","year":"2018","journal-title":"Rheumatology (Oxford)"},{"key":"2024101109362547400_R26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.05.011","article-title":"Different patterns and specific outcomes of large-vessel involvements in giant cell arteritis","volume":"103","author":"de Boysson","year":"2019","journal-title":"J Autoimmun"},{"key":"2024101109362547400_R27","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/rheumatology\/kez362","article-title":"[18F]FDG positron emission tomography and ultrasound in the diagnosis of giant cell arteritis: congruent or complementary imaging methods?","volume":"59","author":"Imfeld","year":"2020","journal-title":"Rheumatology (Oxford)"},{"key":"2024101109362547400_R28","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1136\/annrheumdis-2018-213102","article-title":"Comparison of magnetic resonance angiography and (18) F-fluorodeoxyglucosepositron emission tomography in large-vessel vasculitis","volume":"77","author":"Quinn","year":"2018","journal-title":"Ann Rheum Dis"},{"key":"2024101109362547400_R29","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1136\/annrheumdis-2019-216145","article-title":"Clinical symptoms and associated vascular imaging findings in Takayasu\u2019s arteritis compared to giant cell arteritis","volume":"79","author":"Michailidou","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"2024101109362547400_R30","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1093\/rheumatology\/kex397","article-title":"Evaluation of damage in giant cell arteritis","volume":"57","author":"Kermani","year":"2018","journal-title":"Rheumatology (Oxford)"},{"key":"2024101109362547400_R31","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1002\/acr.23901","article-title":"Prevalence of giant cell arteritis relapse in patients treated with glucocorticoids: a meta-analysis","volume":"72","author":"Mainbourg","year":"2020","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"2024101109362547400_R32","doi-asserted-by":"crossref","first-page":"2789","DOI":"10.1002\/art.22754","article-title":"Adjunctive methotrexate for treatment of giant cell arteritis: an individual patient data meta-analysis","volume":"56","author":"Mahr","year":"2007","journal-title":"Arthritis Rheum"},{"key":"2024101109362547400_R33","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.semarthrit.2018.05.002","article-title":"Arterial lesions in giant cell arteritis: a longitudinal study","volume":"48","author":"Kermani","year":"2019","journal-title":"Semin Arthritis Rheum"},{"key":"2024101109362547400_R34","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1093\/rheumatology\/key015","article-title":"Magnetic resonance angiography in giant cell arteritis: results of a randomized controlled trial of tocilizumab in giant cell arteritis","volume":"57","author":"Reichenbach","year":"2018","journal-title":"Rheumatology (Oxford)"},{"key":"2024101109362547400_R35","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/art.40379","article-title":"(18) F-fluorodeoxyglucose-positron emission tomography as an imaging biomarker in a prospective, longitudinal cohort of patients with large vessel vasculitis","volume":"70","author":"Grayson","year":"2018","journal-title":"Arthritis Rheumatol"},{"key":"2024101109362547400_R36","doi-asserted-by":"crossref","first-page":"3851","DOI":"10.1093\/rheumatology\/keab332","article-title":"Resolution of vascular inflammation in patients with new-onset giant cell arteritis: data from the RIGA study","volume":"60","author":"Schonau","year":"2021","journal-title":"Rheumatology (Oxford)"},{"key":"2024101109362547400_R37","doi-asserted-by":"crossref","first-page":"4384","DOI":"10.1093\/rheumatology\/keaa894","article-title":"Use of 18F-fluorodeoxyglucose positron emission tomography to monitor tocilizumab effect on vascular inflammation in giant cell arteritis","volume":"60","author":"Quinn","year":"2021","journal-title":"Rheumatology (Oxford)"},{"key":"2024101109362547400_R38","doi-asserted-by":"crossref","DOI":"10.1136\/rmdopen-2020-001417","article-title":"Efficacy and safety of tocilizumab in giant cell arteritis: a single centre NHS experience using imaging (ultrasound and PET-CT) as a diagnostic and monitoring tool","volume":"6","author":"Sebastian","year":"2020","journal-title":"RMD Open"},{"key":"2024101109362547400_R39","doi-asserted-by":"crossref","first-page":"5052","DOI":"10.1093\/rheumatology\/keab484","article-title":"Quantitative ultrasound to monitor the vascular response to tocilizumab in giant cell arteritis","volume":"60","author":"Seitz","year":"2021","journal-title":"Rheumatology (Oxford)"},{"key":"2024101109362547400_R40","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-34395-7","article-title":"Novel angiographic scores for evaluation of large vessel vasculitis","volume":"8","author":"Tombetti","year":"2018","journal-title":"Sci Rep"},{"key":"2024101109362547400_R41","doi-asserted-by":"crossref","first-page":"2274","DOI":"10.1007\/s00259-017-3774-5","article-title":"Giant-cell arteritis: concordance study between aortic CT angiography and FDG-PET\/CT in detection of large-vessel involvement","volume":"44","author":"de Boysson","year":"2017","journal-title":"Eur J Nucl Med Mol Imaging"}],"container-title":["Modern Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mr\/advance-article-pdf\/doi\/10.1093\/mr\/roac122\/46527223\/roac122.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mr\/article-pdf\/33\/6\/1145\/59718908\/roac122.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mr\/article-pdf\/33\/6\/1145\/59718908\/roac122.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,11]],"date-time":"2024-10-11T09:36:44Z","timestamp":1728639404000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mr\/article\/33\/6\/1145\/6758245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,11]]},"references-count":41,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,10,11]]},"published-print":{"date-parts":[[2023,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/mr\/roac122","relation":{},"ISSN":["1439-7595","1439-7609"],"issn-type":[{"type":"print","value":"1439-7595"},{"type":"electronic","value":"1439-7609"}],"subject":[],"published-other":{"date-parts":[[2023,11,1]]},"published":{"date-parts":[[2022,10,11]]}}}