{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:42:21Z","timestamp":1740109341738,"version":"3.37.3"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T00:00:00Z","timestamp":1670630400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,22]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Despite the identification of risk factors for relapses in antineutrophil cytoplasmic antibody-associated vasculitis, the relationship between changes in C-reactive protein (CRP) levels after the initial treatment and the incidence of relapse remains unknown. This study aimed to assess the association between the time taken for normalisation of CRP levels and the incidence of relapse in Japanese adult patients with microscopic polyangiitis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This study included 85 consecutive patients with newly diagnosed microscopic polyangiitis who achieved remission after 6 months of immunosuppressive treatment at the Aichi Medical University Hospital between 2009 and 2017. The relationship between the time to normalisation of CRP after the initial immunosuppressive treatment and relapse incidences was evaluated using multivariable Cox proportional hazard models.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>During the follow-up period, 13 (30.2%), 7 (41.2%), and 16 (64.0%) patients relapsed (P\u2009=\u2009.025) within 1\u201314, 15\u201328, and \u226529\u2009days of normalisation, respectively. The hazard ratios [95% confidence intervals (CIs)] for the time to normalisation of CRP of 1\u201314, 15\u201328, and \u226529\u2009days were 1.00 (reference), 2.42 (95% CI: 0.92\u20136.39), and 3.48 (95% CI: 1.56\u20137.76), respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>A significant association between the time to normalisation of CRP and the relapse incidence in Japanese patients with microscopic polyangiitis was observed.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roac146","type":"journal-article","created":{"date-parts":[[2022,12,10]],"date-time":"2022-12-10T12:23:42Z","timestamp":1670675022000},"page":"151-156","source":"Crossref","is-referenced-by-count":1,"title":["Time to normalisation of C-reactive protein and incidence of relapse in microscopic polyangiitis: A medical records review study in Japan"],"prefix":"10.1093","volume":"34","author":[{"given":"Makoto","family":"Yamaguchi","sequence":"first","affiliation":[{"name":"Department of Nephrology and Rheumatology, Aichi Medical University , Nagakute, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayumi","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Aichi Medical University , Nagakute, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Sugiyama","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Aichi Medical University , Nagakute, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiho","family":"Iwagaitsu","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Aichi Medical University , Nagakute, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hironobu","family":"Nobata","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Aichi Medical University , Nagakute, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroshi","family":"Kinashi","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Aichi Medical University , Nagakute, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Katsuno","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Aichi Medical University , Nagakute, Aichi, Japan"},{"name":"Department of Nephrology and Rheumatology, Aichi Medical University Medical Center , Okazaki, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiko","family":"Ando","sequence":"additional","affiliation":[{"name":"Department of Advanced Medicine, Data Coordinating Center, Nagoya University Hospital , Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Kubo","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine, Nagoya University Graduate School of Medicine , Nagoya, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shogo","family":"Banno","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Aichi Medical University , Nagakute, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiko","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Aichi Medical University , Nagakute, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9861-5331","authenticated-orcid":false,"given":"Takuji","family":"Ishimoto","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Aichi Medical University , Nagakute, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,12,10]]},"reference":[{"key":"2023122314261029500_R1","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1002\/art.40313","article-title":"The epidemiology of antineutrophil cytoplasmic autoantibody associated vasculitis in Olmsted County, Minnesota: a twenty-year US population-based study","volume":"69","author":"Berti","year":"2017","journal-title":"Arthritis Rheumatol"},{"key":"2023122314261029500_R2","doi-asserted-by":"crossref","first-page":"i14","DOI":"10.1093\/ndt\/gfv022","article-title":"Classification, epidemiology and clinical subgrouping of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis","volume":"30","author":"Watts","year":"2015","journal-title":"Nephrol Dial Transplant"},{"key":"2023122314261029500_R3","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1093\/rheumatology\/kew232","article-title":"Incidence of ANCA-associated vasculitis in a UK mixed ethnicity population","volume":"55","author":"Pearce","year":"2016","journal-title":"Rheumatology (Oxford)"},{"key":"2023122314261029500_R4","doi-asserted-by":"crossref","first-page":"iii42","DOI":"10.1093\/rheumatology\/keaa089","article-title":"An update on the epidemiology of ANCA-associated vasculitis","volume":"59","author":"Mohammad","year":"2020","journal-title":"Rheumatology (Oxford)"},{"key":"2023122314261029500_R5","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1002\/art.10459","article-title":"High rate of renal relapse in 71 patients with Wegener\u2019s granulomatosis under maintenance of remission with low-dose methotrexate","volume":"47","author":"Reinhold-Keller","year":"2002","journal-title":"Arthritis 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