{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T10:13:46Z","timestamp":1767867226742,"version":"3.49.0"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T00:00:00Z","timestamp":1670457600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["15ek0109121s0101 and 18ek0109360h0001"],"award-info":[{"award-number":["15ek0109121s0101 and 18ek0109360h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The aim of this article is to evaluate the effectiveness and safety of rituximab (RTX) for microscopic polyangiitis and granulomatosis with polyangiitis in Japan.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this prospective observational study, all patients with microscopic polyangiitis and granulomatosis with polyangiitis administered RTX were enrolled at each institution. During the observation period of 2 years, data up to 6 months were analysed. Cox proportional hazards analysis was used to assess the factors associated with an outcome.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 75 patients who received RTX for remission induction therapy, 53 achieved remission by the sixth month and 50 were in remission at the sixth month. During therapy, 39 serious adverse events were observed in 24 patients, 21 serious infections in 16 patients, and 9 patients died. No factors were associated with remission; however, there was a significant difference between patients with and without remission in serious adverse events (22.6% vs. 54.5%), serious infections (11.3% vs. 45.4%), and death (1.9% vs. 36.4%). The hazard ratio (95% confidence interval) for serious infection was 3.49 (1.29\u20139.74) for patients aged\u2009\u2265\u200975\u2009years and 3.53 (1.31\u20139.53) for pulmonary complications. Four patients maintained remission for 6\u2009months.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The effectiveness and safety of RTX for microscopic polyangiitis and granulomatosis with polyangiitis for up to 6\u2009months was demonstrated.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roac150","type":"journal-article","created":{"date-parts":[[2022,12,8]],"date-time":"2022-12-08T12:29:22Z","timestamp":1670502562000},"page":"1117-1124","source":"Crossref","is-referenced-by-count":7,"title":["Nation-wide cohort study of remission induction therapy using rituximab in Japanese patients with antineutrophil cytoplasmic antibody\u2013associated vasculitis: Effectiveness and safety in the first 6 months"],"prefix":"10.1093","volume":"33","author":[{"given":"Kenji","family":"Nagasaka","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Ome Municipal General Hospital , Ome,","place":["Japan"]},{"name":"Department of Rheumatology, Tokyo Medical and Dental University (TMDU) , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Saitama Medical Center, Saitama Medical University , Kawagoe,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Dobashi","sequence":"additional","affiliation":[{"name":"Division of Hematology, Rheumatology and Respiratory Medicine, Department of Internal Medicine, Faculty of Medicine, Kagawa University , Kagawa,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Nagafuchi","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, St. Marianna University School of Medicine , Kawasaki,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken-Ei","family":"Sada","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Rheumatology, Endocrinology and Metabolism, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences , Okayama,","place":["Japan"]},{"name":"Department of Clinical Epidemiology, Kochi Medical School, Kochi University , Nankoku,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Komagata","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Kyorin University School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Yamamura","sequence":"additional","affiliation":[{"name":"Center for Rheumatology, Department of Internal Medicine, Okayama Saiseikai General Hospital , Okayama,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaru","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Endocrinology and Nephrology, Graduate School of Medicine and Faculty of Medicine, Hokkaido University , Sapporo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomomi","family":"Endo","sequence":"additional","affiliation":[{"name":"Division of Nephrology and Dialysis, Kitano Hospital, The Tazuke Kofukai Medical Research Institute , Osaka,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Izaya","family":"Nakaya","sequence":"additional","affiliation":[{"name":"Department of Nephrology and Rheumatology, Iwate Prefectural Central Hospital , Morioka,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsutomu","family":"Takeuchi","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yohko","family":"Murakawa","sequence":"additional","affiliation":[{"name":"Internal Medicine III, Shimane University Faculty of Medicine , Izumo, Shimane,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiko","family":"Sugihara","sequence":"additional","affiliation":[{"name":"Department of Medicine and Rheumatology, Tokyo Metropolitan Geriatric Hospital , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masaya","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Hematology, Nephrology, and Rheumatology, Akita University Graduate School of Medicine , Akita,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taichi","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Faculty of Medicine, University of Tsukuba , Ibaraki,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shunsuke","family":"Furuta","sequence":"additional","affiliation":[{"name":"Department of Allergy and Clinical Immunology, Chiba University Hospital , Chiba,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoto","family":"Tamura","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Rheumatology, Juntendo University Faculty of Medicine , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Karasawa","sequence":"additional","affiliation":[{"name":"Department of Nephrology, School of Medicine, Tokyo Women\u2019s Medical University , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shogo","family":"Banno","sequence":"additional","affiliation":[{"name":"Department of 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