{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T01:04:10Z","timestamp":1778202250695,"version":"3.51.4"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T00:00:00Z","timestamp":1674259200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,22]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To develop a novel scoring system to predict colchicine resistance in Familial Mediterranean fever (FMF) based on the initial features of the patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The medical records of patients were analyzed prior to the initiation of colchicine. After generating a predictive score in the initial cohort, it was applied to an independent cohort for external validation of effectiveness and reliability.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 1418 patients with FMF, 56 (3.9%) were colchicine resistant (cr) and 1312 (96.1%) were colchicine responsive. Recurrent arthritis (4 points), protracted febrile myalgia (8 points), erysipelas-like erythema (2 points), exertional leg pain (2 points), and carrying M694V homozygous mutation (4 points) were determined as the parameters for predicting cr-FMF in the logistic regression model. The cut-off value of 9 was 87% sensitive and 82% specific to foresee the risk of cr-FMF in the receiver operating characteristic. Validation of the scoring system with an independent group (cr-FMF = 107, colchicine responsive = 1935) revealed that the cut-off value was 82% sensitive and 79% specific to identify the risk of cr-FMF.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>By constructing this reliable and predictor tool, we enunciate that predicting cr-FMF at the initiation of the disease and interfering timely before the emergence of complications will be possible.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/road008","type":"journal-article","created":{"date-parts":[[2023,1,21]],"date-time":"2023-01-21T08:20:06Z","timestamp":1674289206000},"page":"220-225","source":"Crossref","is-referenced-by-count":6,"title":["PREDICT-crFMF score: A novel model for predicting colchicine resistance in children with familial Mediterranean fever"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3594-7387","authenticated-orcid":false,"given":"Nuray","family":"Aktay Ayaz","sequence":"first","affiliation":[{"name":"Department of Pediatric Rheumatology, Istanbul Faculty of Medicine, Istanbul University , Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatma G\u00fcl","family":"Demirkan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Istanbul Faculty of Medicine, Istanbul University , Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taner","family":"Co\u015fkuner","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, University of Health Sciences, Umraniye Research and Training Hospital , Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ferhat","family":"Demir","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Ac\u0131badem Healthcare Group , Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ay\u015fe","family":"Tanatar","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Istanbul Faculty of Medicine, Istanbul University , Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mustafa","family":"\u00c7akan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, University of Health Sciences, Umraniye Research and Training Hospital , Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eerife G\u00fcl","family":"Karada\u011f","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Istanbul Faculty of Medicine, Istanbul University , Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcl\u00e7in Otar","family":"Yener","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Sanliurfa Training and Research Hospital , Sanliurfa, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K\u00fcbra","family":"\u00d6zt\u00fcrk","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Istanbul Medeniyet University, School of Medicine, Goztepe Research and Training Hospital , Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra","family":"Ba\u011flan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, University of Health Sciences, Dr. Sami Ulus Obstetrics and Gynecology, Pediatric Health and Disease Training and Research Hospital , Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Figen","family":"\u00c7akmak","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Istanbul Faculty of Medicine, Istanbul University , Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eeng\u00fcl","family":"\u00c7a\u011flayan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, University of Health Sciences, Umraniye Research and Training Hospital , Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Semanur","family":"\u00d6zdel","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, University of Health Sciences, Dr. Sami Ulus Obstetrics and Gynecology, Pediatric Health and Disease Training and Research Hospital , Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kadir","family":"Ulu","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, University of Health Sciences, Umraniye Research and Training Hospital , Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bet\u00fcl","family":"S\u00f6zeri","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, University of Health Sciences, Umraniye Research and Training Hospital , Istanbul, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hafize Emine","family":"S\u00f6nmez","sequence":"additional","affiliation":[{"name":"Department of Pediatric Rheumatology, Kocaeli University, Kocaeli School of Medicine , Kocaeli, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,1,21]]},"reference":[{"key":"2023122314262004600_R1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2019.102305","article-title":"Autoinflammation: lessons from the study of familial Mediterranean fever","volume":"104","author":"Skendros","year":"2019","journal-title":"J 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