{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T02:46:44Z","timestamp":1766544404777,"version":"3.37.3"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,26]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>The present study compared the clinical features of patients with primary Sj\u00f6gren\u2019s syndrome (pSS) with and without nephrolithiasis and\/or nephrocalcinosis to determine factors related to renal dysfunction.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The clinical features of 68 patients with anti-Sjogren's syndrome antigen A (SSA)\/Ro-antibody\u2013positive pSS with and without nephrolithiasis and\/or nephrocalcinosis who underwent abdominal computed tomography and\/or ultrasonography were retrospectively analysed.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of the 68 patients with anti-SSA-antibody\u2013positive pSS, 23 (33%) had renal nephrolithiasis and\/or nephrocalcinosis, whereas 45 (67%) did not. Fourteen (20%) patients had renal dysfunction at diagnostic imaging. Among five patients who underwent renal biopsy, four patients with renal nephrolithiasis and\/or nephrocalcinosis were diagnosed with tubulointerstitial nephritis, and one without nephrolithiasis and\/or nephrocalcinosis was diagnosed with minimal change nephrotic syndrome. Estimated glomerular filtration rate at diagnostic imaging was significantly lower in patients with than without nephrolithiasis and\/or nephrocalcinosis group (P\u2009=\u20090.010). In addition to nephrolithiasis and\/or nephrocalcinosis (odds ratio [OR], 3.467; P\u2009=\u20090.045), the gap between serum sodium and chloride concentrations (OR, 10.400; P\u2009=\u20090.012) and increased urinary \u03b22-microglobulin (OR, 5.444; P\u2009=\u20090.033) were associated with renal dysfunction at the time of diagnostic imaging.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Nephrolithiasis and\/or nephrocalcinosis, normal anion gap metabolic acidosis, and tubulointerstitial damage are associated with renal dysfunction in patients with pSS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/road023","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T02:40:20Z","timestamp":1677206420000},"page":"376-381","source":"Crossref","is-referenced-by-count":4,"title":["Nephrolithiasis and\/or nephrocalcinosis is significantly related to renal dysfunction in patients with primary Sj\u00f6gren\u2019s syndrome"],"prefix":"10.1093","volume":"34","author":[{"given":"Yuhei","family":"Fujisawa","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Kanazawa University Hospital , Kanazawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6231-0683","authenticated-orcid":false,"given":"Ichiro","family":"Mizushima","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Kanazawa University Hospital , Kanazawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunori","family":"Suzuki","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Kanazawa University Hospital , Kanazawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4613-2116","authenticated-orcid":false,"given":"Mitsuhiro","family":"Kawano","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Kanazawa University Hospital , Kanazawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,2,21]]},"reference":[{"key":"2024022623083323300_R1","first-page":"362","article-title":"A multicentre study of 95 biopsy-proven cases of renal disease in primary Sj\u00f6gren\u2019s syndrome","volume":"56","author":"Jasiek","year":"2017","journal-title":"Rheumatology (Oxford)"},{"key":"2024022623083323300_R2","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/1756-185X.13182","article-title":"Renal involvement in primary Sj\u00f6gren\u2019s syndrome: a retrospective study of 103 biopsy-proven cases from a single center in 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