{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T13:08:48Z","timestamp":1779109728439,"version":"3.51.4"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,2,26]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The association of inflammation markers with hypertension (HTN) in primary Sj\u00f6gren\u2019s syndrome (pSS) remains controversial. We aimed to investigate whether inflammation markers are at increased risk of developing HTN in pSS patients.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective cohort study included pSS patients (n\u2009=\u2009380) between May 2011 and May 2020 from the Third People\u2019s Hospital of Chengdu. Multivariable Cox regression analyses were used to estimate hazard ratios (HRs) of the potential inflammation markers for pSS-HTN. Subsequently, the dose\u2013response relationships were also used.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Out of 380 pSS patients, 171 (45%) developed HTN, and the median follow-up period was 4.16\u2009years. Univariable Cox regression analysis showed that the erythrocyte sedimentation rate (ESR) and neutrophils were significantly associated with the incident HTN (P\u2009&amp;lt;\u20090.05). After adjustment for covariates, this association between ESR (adjusted HR 1.017, 95%CI: 1.005\u20131.027, P\u2009=\u2009.003), neutrophils (adjusted HR 1.356, 95%CI: 1.113\u20131.653, P\u2009=\u2009.003), and HTN remained significant. The dose\u2013effect relationship was also found between ESR, neutrophils, and HTN (P\u2009=\u2009.001).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Inflammation markers may play an important role in the incident HTN in pSS.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/road032","type":"journal-article","created":{"date-parts":[[2023,3,29]],"date-time":"2023-03-29T01:49:42Z","timestamp":1680054582000},"page":"369-375","source":"Crossref","is-referenced-by-count":5,"title":["Relationships between inflammation markers and the risk of hypertension in primary Sj\u00f6gren\u2019s syndrome: A retrospective cohort study"],"prefix":"10.1093","volume":"34","author":[{"given":"Yan","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Cardiology, Affiliated Hospital of Southwest Jiaotong University, The Third People\u2019s Hospital of Chengdu , Chengdu, Sichuan, China"},{"name":"Department of Geriatrics, North Sichuan Medical College , Nanchong, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Affiliated Hospital of Southwest Jiaotong University, The Third People\u2019s Hospital of Chengdu , Chengdu, Sichuan, China"},{"name":"The Center of Gastrointestinal and Minimally Invasive Surgery, Department of General Surgery, The Affiliated Hospital of Southwest Jiaotong University, The Third People's Hospital of Chengdu , Chengdu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Affiliated Hospital of Southwest Jiaotong University, The Third People\u2019s Hospital of Chengdu , Chengdu, Sichuan, China"},{"name":"Department of Geriatrics, North Sichuan Medical College , Nanchong, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1123-4086","authenticated-orcid":false,"given":"Han","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Affiliated Hospital of Southwest Jiaotong University, The Third People\u2019s Hospital of Chengdu , Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,3,28]]},"reference":[{"key":"2024022623082884200_R1","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0140-6736(05)66990-5","article-title":"Sj\u00f6gren\u2019s syndrome","volume":"366","author":"Fox","year":"2005","journal-title":"Lancet"},{"key":"2024022623082884200_R2","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1136\/annrheumdis-2014-205375","article-title":"Epidemiology of primary Sj\u00f6gren\u2019s syndrome: a systematic review and 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