{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:13:23Z","timestamp":1791688403171,"version":"4.3.4"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T00:00:00Z","timestamp":1686009600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,28]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Determining which sites were important to differentiate polymyalgia rheumatica (PMR) from rheumatoid arthritis (RA) using 18F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET-CT) is challenging.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients with PMR or RA who were undergoing PET-CT were recruited at two mutual-aid hospitals in Japan between 2009 and 2018. Classification and regression tree (CART) analyses were performed to identify FDG uptake patterns that differentiated PMR from RA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We enrolled 35 patients with PMR and 46 patients with RA. Univariate CART analysis showed that FDG uptake in the shoulder joints, spinous processes of the lumbar vertebrae, pubic symphysis, sternoclavicular joints, ischial tuberosities, greater trochanters, and hip joints differentiated PMR from RA. Multivariate CART analysis revealed that FDG uptake by at least one of the ischial tuberosities had the highest diagnostic value for distinguishing PMR from RA (sensitivity, 77.1%; specificity, 82.6%). We performed the same CART analysis to patients who had not undergone treatment (PMR, n\u2009=\u200928; RA, n\u2009=\u20099). Similar results were obtained, and sensitivity and specificity were increased (sensitivity, 89.3%; specificity, 88.8%).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>In PET-CT, FDG uptake by at least one of the ischial tuberosities best discriminates between PMR and RA.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/road051","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T13:52:02Z","timestamp":1686318722000},"page":"474-478","source":"Crossref","is-referenced-by-count":5,"title":["Diagnostic value of\u00a018F-fluorodeoxyglucose positron emission tomography and\u00a0computed tomography for\u00a0differentiating polymyalgia rheumatica and\u00a0rheumatoid arthritis: Using classification and\u00a0regression tree analysis"],"prefix":"10.1093","volume":"34","author":[{"given":"Daisuke","family":"Ikuma","sequence":"first","affiliation":[{"name":"Nephrology Center, Toranomon Hospital Branch , Kawasaki, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Sawa","sequence":"additional","affiliation":[{"name":"Nephrology Center, Toranomon Hospital Branch , Kawasaki, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Yamanouchi","sequence":"additional","affiliation":[{"name":"Nephrology Center, Toranomon Hospital Branch , Kawasaki, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1494-3291","authenticated-orcid":false,"given":"Yuki","family":"Oba","sequence":"additional","affiliation":[{"name":"Nephrology Center, Toranomon Hospital Branch , Kawasaki, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Mizuno","sequence":"additional","affiliation":[{"name":"Nephrology Center, Toranomon Hospital Branch , Kawasaki, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatsuya","family":"Suwabe","sequence":"additional","affiliation":[{"name":"Nephrology Center, Toranomon Hospital Branch , Kawasaki, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Hoshino","sequence":"additional","affiliation":[{"name":"Nephrology Center, Toranomon Hospital Branch , Kawasaki, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshifumi","family":"Ubara","sequence":"additional","affiliation":[{"name":"Nephrology Center, Toranomon Hospital Branch , Kawasaki, Kanagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,6]]},"reference":[{"key":"2024032817141282400_R1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1056\/NEJMra011913","article-title":"Polymyalgia rheumatica and\u00a0giant-cell arteritis","volume":"347","author":"Salvarani","year":"2002","journal-title":"N Engl J Med"},{"key":"2024032817141282400_R2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1136\/ard.49.3.155","article-title":"Rarity of\u00a0synovitis in\u00a0polymyalgia rheumatica","volume":"49","author":"Kyle","year":"1990","journal-title":"Ann Rheum Dis"},{"key":"2024032817141282400_R3","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0140-6736(01)06075-5","article-title":"Rheumatoid arthritis","volume":"358","author":"Lee","year":"2001","journal-title":"Lancet"},{"key":"2024032817141282400_R4","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1093\/rheumatology\/38.3.228","article-title":"Does the age of\u00a0onset of\u00a0rheumatoid arthritis influence phenotype? 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