{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,9]],"date-time":"2026-08-09T02:17:46Z","timestamp":1786241866550,"version":"build-2736575974"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,6,2]],"date-time":"2023-06-02T00:00:00Z","timestamp":1685664000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,28]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>In our study, we investigated the presence of subclinical enthesitis by ultrasonography (US) in asymptomatic patients with enthesitis-related arthritis (ERA) and sacroiliitis associated with familial Mediterranean fever (FMF).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A total of 50 patients, including 35 patients with ERA and 15 with sacroiliitis associated with FMF, were included in the study. All patients were evaluated with US by a paediatric radiologist. Enthesis of seven tendons (common extensor and flexor tendons, quadriceps tendon, proximal and distal patellar tendon, Achilles tendon, and plantar fascia) was examined on both sides.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Subclinical enthesitis was detected in 10 ERA (28.5%) and three FMF (20%) patients. Enthesitis was radiologically diagnosed in 16 (2.3%) out of 700 evaluated entheseal sites. The most frequent sites of enthesitis were Achilles (37.5%) and quadriceps (31.3%) tendons. All patients were in clinical remission and had no active complaints, and acute phase reactants were within normal limits. Therefore, the patients were followed up without treatment change. However, disease flare-up was observed in three of these patients (23.1%) during the follow-up, and their treatments were intensified.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Our results showed that the US can be particularly helpful in detecting subclinical enthesitis and predicting disease flare-ups.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/road053","type":"journal-article","created":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T00:10:17Z","timestamp":1685751017000},"page":"607-613","source":"Crossref","is-referenced-by-count":6,"title":["Subclinical enthesitis in\u00a0enthesitis-related arthritis and\u00a0sacroiliitis associated with familial Mediterranean fever"],"prefix":"10.1093","volume":"34","author":[{"given":"Seher","family":"Sener","sequence":"first","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe Faculty of Medicine , Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdal","family":"Atalay","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics, Sanliurfa Training and Research Hospital , Sanliurfa, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adalet Elcin","family":"Yildiz","sequence":"additional","affiliation":[{"name":"Department of Radiology, Hacettepe University Faculty of Medicine , Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muserref","family":"Kasap Cuceoglu","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe Faculty of Medicine , Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ozge","family":"Basaran","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe Faculty of Medicine , Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ezgi Deniz","family":"Batu","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe Faculty of Medicine , Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yelda","family":"Bilginer","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe Faculty of Medicine , Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2883-7868","authenticated-orcid":false,"given":"Seza","family":"Ozen","sequence":"additional","affiliation":[{"name":"Division of Pediatric Rheumatology, Department of Pediatrics, Hacettepe Faculty of Medicine , Ankara, Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,6,2]]},"reference":[{"key":"2024032817141438600_R1","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/art.39458","article-title":"Review: enthesitis: new insights into pathogenesis, diagnostic modalities, and\u00a0treatment","volume":"68","author":"Kehl","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"2024032817141438600_R2","doi-asserted-by":"crossref","first-page":"221","DOI":"10.4078\/jrd.2018.25.4.221","article-title":"Enthesitis-related arthritis","volume":"25","author":"Hahn","year":"2018","journal-title":"J Rheum Dis"},{"key":"2024032817141438600_R3","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1007\/s10067-022-06080-8","article-title":"The performances of\u00a0the ILAR, ASAS, and\u00a0PRINTO classification criteria in\u00a0ERA patients: a comparison study","volume":"41","author":"Kaya Akca","year":"2022","journal-title":"Clin Rheumatol"},{"key":"2024032817141438600_R4","doi-asserted-by":"crossref","first-page":"175","DOI":"10.24953\/turkjped.2020.02.002","article-title":"Sacroiliitis associated with familial Mediterranean fever in\u00a0childhood: a case series and\u00a0review of\u00a0literature","volume":"62","author":"Y\u0131ld\u0131r\u0131m","year":"2020","journal-title":"Turk J Pediatr"},{"key":"2024032817141438600_R5","first-page":"124","article-title":"Comparison of\u00a0patients with familial Mediterranean fever accompanied with sacroiliitis and\u00a0patients with juvenile spondyloarthropathy","volume":"35","author":"S\u00f6nmez","year":"2017","journal-title":"Clin Exp Rheumatol"},{"key":"2024032817141438600_R6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12969-021-00613-2","article-title":"Frequency of\u00a0juvenile idiopathic arthritis and\u00a0associated uveitis in\u00a0pediatric rheumatology clinics in\u00a0Turkey: a retrospective study, JUPITER","volume":"19","author":"Sahin","year":"2021","journal-title":"Pediatr Rheumatol Online J"},{"key":"2024032817141438600_R7","first-page":"2445","article-title":"Prevalence of\u00a0juvenile chronic arthritis and\u00a0familial Mediterranean fever in\u00a0Turkey: a field study","volume":"25","author":"Ozen","year":"1998","journal-title":"J Rheumatol"},{"key":"2024032817141438600_R8","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s10067-008-0980-3","article-title":"The frequency of\u00a0sacroiliitis in\u00a0familial Mediterranean fever and\u00a0the role of\u00a0HLA-B27 and\u00a0MEFV mutations in\u00a0the development of\u00a0sacroiliitis","volume":"28","author":"Ka\u015fifo\u011flu","year":"2009","journal-title":"Clin Rheumatol"},{"key":"2024032817141438600_R9","first-page":"1335","article-title":"Enthesalgia in\u00a0childhood: site-specific tenderness in\u00a0healthy subjects and\u00a0in patients with seronegative enthesopathic arthropathy","volume":"30","author":"Sherry","year":"2003","journal-title":"J Rheumatol"},{"key":"2024032817141438600_R10","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1136\/ard.62.2.127","article-title":"Assessment of\u00a0enthesitis in\u00a0ankylosing spondylitis","volume":"62","author":"Heuft-Dorenbosch","year":"2003","journal-title":"Ann Rheum Dis"},{"key":"2024032817141438600_R11","first-page":"347","article-title":"Clinical and\u00a0ultrasound assessment of\u00a0enthesis in\u00a0psoriatic arthritis in\u00a0a Romanian cohort","volume":"44","author":"Florescu","year":"2018","journal-title":"Curr Health Sci J"},{"key":"2024032817141438600_R12","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1002\/art.38197","article-title":"Detection of\u00a0enthesitis in\u00a0children with enthesitis-related arthritis: dolorimetry compared to ultrasonography","volume":"66","author":"Weiss","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"2024032817141438600_R13","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.molcel.2007.08.029","article-title":"Pyrin activates the ASC pyroptosome in\u00a0response to engagement by autoinflammatory PSTPIP1 mutants","volume":"28","author":"Yu","year":"2007","journal-title":"Mol Cell"},{"key":"2024032817141438600_R14","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/1529-0131(199804)41:4<694::AID-ART17>3.0.CO;2-#","article-title":"Characteristic magnetic resonance imaging entheseal changes of\u00a0knee synovitis in\u00a0spondylarthropathy","volume":"41","author":"McGonagle","year":"1998","journal-title":"Arthritis Rheum"},{"key":"2024032817141438600_R15","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1002\/art.10812","article-title":"Assessment of\u00a0peripheral enthesitis in\u00a0the spondylarthropathies by ultrasonography combined with power Doppler: a cross-sectional study","volume":"48","author":"D\u2019Agostino","year":"2003","journal-title":"Arthritis Rheum"},{"key":"2024032817141438600_R16","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.jbspin.2003.06.003","article-title":"Evaluation of\u00a0metacarpophalangeal joint synovitis in\u00a0rheumatoid arthritis by power Doppler technique: relationship between synovial vascularization and\u00a0periarticular bone mineral density","volume":"71","author":"Ozgocmen","year":"2004","journal-title":"Joint Bone Spine"},{"key":"2024032817141438600_R17","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1136\/ard.2007.084251","article-title":"Validity of\u00a0enthesis ultrasound assessment in\u00a0spondyloarthropathy","volume":"68","author":"de Miguel","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"2024032817141438600_R18","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1002\/acr.22191","article-title":"Defining enthesitis in spondyloarthritis by ultrasound: results of\u00a0a Delphi process and\u00a0of a reliability reading exercise","volume":"66","author":"Terslev","year":"2014","journal-title":"Arthritis Care Res"},{"key":"2024032817141438600_R19","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s10067-012-2111-4","article-title":"Power Doppler ultrasonography of\u00a0painful Achilles tendons and\u00a0entheses in\u00a0patients with and\u00a0without spondyloarthropathy: a comparison with clinical examination and\u00a0contrast-enhanced MRI","volume":"32","author":"Wiell","year":"2013","journal-title":"Clin Rheumatol"},{"key":"2024032817141438600_R20","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1007\/s00247-015-3313-0","article-title":"Ultrasound of\u00a0the joints and\u00a0entheses in\u00a0healthy children","volume":"45","author":"Chauvin","year":"2015","journal-title":"Pediatr Radiol"},{"key":"2024032817141438600_R21","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s00247-019-04464-8","article-title":"Differential pattern of\u00a0Doppler signals at lower-extremity entheses of\u00a0healthy children","volume":"49","author":"Roth","year":"2019","journal-title":"Pediatr Radiol"},{"key":"2024032817141438600_R22","doi-asserted-by":"crossref","first-page":"190","DOI":"10.3899\/jrheum.180168","article-title":"Toward new classification criteria for\u00a0juvenile idiopathic arthritis: first steps, pediatric rheumatology international trials organization international consensus","volume":"46","author":"Martini","year":"2019","journal-title":"J Rheumatol"},{"key":"2024032817141438600_R23","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1136\/annrheumdis-2019-215048","article-title":"Classification criteria for\u00a0autoinflammatory recurrent fevers","volume":"78","author":"Gattorno","year":"2019","journal-title":"Ann Rheum Dis"},{"key":"2024032817141438600_R24","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.3899\/jrheum.181095","article-title":"OMERACT Definitions for\u00a0Ultrasonographic Pathologies and\u00a0Elementary Lesions of\u00a0Rheumatic Disorders 15 Years On","volume":"46","author":"Bruyn","year":"2019","journal-title":"J Rheumatol"},{"key":"2024032817141438600_R25","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1093\/mrcr\/rxac031","article-title":"Down-regulated Th17 cells in\u00a0a patient with familial Mediterranean fever associated with amyloid A amyloidosis in\u00a0the treatment of\u00a0canakinumab","volume":"7","author":"Goto","year":"2023","journal-title":"Mod Rheumatol Case Rep"},{"key":"2024032817141438600_R26","first-page":"1","article-title":"The role of\u00a0interleukin-17 in\u00a0juvenile idiopathic arthritis: from pathogenesis to treatment","volume":"58","author":"Paroli","year":"2022","journal-title":"Medicina (Kaunas)"},{"key":"2024032817141438600_R27","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pgen.1008038","article-title":"Genome-wide association study in\u00a0Turkish and\u00a0Iranian populations identify rare familial Mediterranean fever gene (MEFV) polymorphisms associated with ankylosing spondylitis","volume":"15","author":"Li","year":"2019","journal-title":"PLoS Genet"},{"key":"2024032817141438600_R28","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1111\/j.1365-2567.2009.03240.x","article-title":"Interleukin-17 and\u00a0its target genes: mechanisms of\u00a0interleukin-17 function in\u00a0disease","volume":"129","author":"Onishi","year":"2010","journal-title":"Immunology"},{"key":"2024032817141438600_R29","first-page":"515","article-title":"Interleukin 17 levels are increased in\u00a0juvenile idiopathic arthritis synovial fluid and\u00a0induce synovial fibroblasts to produce proinflammatory cytokines and\u00a0matrix metalloproteinases","volume":"35","author":"Agarwal","year":"2008","journal-title":"J Rheumatol"},{"key":"2024032817141438600_R30","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.3899\/jrheum.081179","article-title":"Th1 and\u00a0Th17 predominance in\u00a0the enthesitis-related arthritis form of\u00a0juvenile idiopathic arthritis","volume":"36","author":"Mahendra","year":"2009","journal-title":"J Rheumatol"},{"key":"2024032817141438600_R31","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1136\/ard-2022-222849","article-title":"Secukinumab in\u00a0enthesitis-related arthritis and\u00a0juvenile psoriatic arthritis: a randomised, double-blind, placebo-controlled, treatment withdrawal, phase 3 trial","volume":"82","author":"Brunner","year":"2023","journal-title":"Ann Rheum Dis"},{"key":"2024032817141438600_R32","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1002\/art.33507","article-title":"Enrichment of\u00a0circulating interleukin-17-secreting interleukin-23 receptor-positive \u03b3\/\u03b4 T cells in\u00a0patients with active ankylosing spondylitis","volume":"64","author":"Kenna","year":"2012","journal-title":"Arthritis Rheum"},{"key":"2024032817141438600_R33","first-page":"S77","article-title":"Serum interleukin 17 and\u00a0interleukin 18 levels in\u00a0familial Mediterranean fever","volume":"23","author":"Haznedaroglu","year":"2005","journal-title":"Clin Exp Rheumatol"},{"key":"2024032817141438600_R34","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1002\/acr.20444","article-title":"Ultrasonography for\u00a0detecting enthesitis in\u00a0juvenile idiopathic arthritis","volume":"63","author":"Jousse-Joulin","year":"2011","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"2024032817141438600_R35","first-page":"143","article-title":"Sonologic enthesitis in\u00a0children with enthesitis-related arthritis","volume":"34","author":"Shenoy","year":"2016","journal-title":"Clin Exp Rheumatol"},{"key":"2024032817141438600_R36","first-page":"67","article-title":"Diagnosis and\u00a0treatment of\u00a0enthesitis-related arthritis","volume":"2012","author":"Weiss","year":"2012","journal-title":"Adolesc Health Med Ther"},{"key":"2024032817141438600_R37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2020.00971","article-title":"The use of\u00a0interleukine-1 inhibitors in\u00a0familial Mediterranean fever patients: a narrative review","volume":"11","author":"Hentgen","year":"2020","journal-title":"Front Immunol"},{"key":"2024032817141438600_R38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s42358-020-0117-1","article-title":"Assessment of\u00a0effectiveness of\u00a0anakinra and\u00a0canakinumab in\u00a0patients with colchicine-resistant\/unresponsive familial Mediterranean fever","volume":"60","author":"\u015eahin","year":"2020","journal-title":"Adv Rheumatol"},{"key":"2024032817141438600_R39","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1136\/annrheumdis-2015-208690","article-title":"EULAR recommendations for\u00a0the management of\u00a0familial Mediterranean fever","volume":"75","author":"Ozen","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"2024032817141438600_R40","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/rheumatology\/kep410","article-title":"Monitoring Achilles enthesitis in\u00a0ankylosing spondylitis during TNF-alpha antagonist therapy: an ultrasound study","volume":"49","author":"Aydin","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"2024032817141438600_R41","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/art.40778","article-title":"Regression of\u00a0peripheral subclinical enthesopathy in\u00a0therapy-naive patients treated with ustekinumab for\u00a0moderate-to-severe chronic plaque psoriasis: a fifty-two-week, prospective, open-label feasibility study","volume":"71","author":"Savage","year":"2019","journal-title":"Arthritis Rheumatol"}],"container-title":["Modern Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/mr\/advance-article-pdf\/doi\/10.1093\/mr\/road053\/53136351\/road053.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mr\/article-pdf\/34\/3\/607\/57109279\/road053.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/mr\/article-pdf\/34\/3\/607\/57109279\/road053.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T17:55:36Z","timestamp":1711648536000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/mr\/article\/34\/3\/607\/7189758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,2]]},"references-count":41,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,6,2]]},"published-print":{"date-parts":[[2024,3,28]]}},"URL":"https:\/\/doi.org\/10.1093\/mr\/road053","relation":{},"ISSN":["1439-7595","1439-7609"],"issn-type":[{"value":"1439-7595","type":"print"},{"value":"1439-7609","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,5,1]]},"published":{"date-parts":[[2023,6,2]]}}}