{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T22:34:43Z","timestamp":1775687683459,"version":"3.50.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>Ageing and obesity are major risk factors for osteoarthritis (OA), a widespread disease currently lacking efficient treatments. Senescence-accelerated mouse prone 8 (SAMP8) display early onset ageing phenotypes, including OA. This study investigates the impacts of high-fat diet (HFD)-induced obesity on OA development in SAMP8.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>SAMP8 at 5\u2009weeks were fed either a normal chow diet or an HFD for 10\u2009weeks to induce obesity. Parameters related to obesity, liver function, and lipid and glucose metabolism were analysed. At 14\u2009weeks of age, knee joint pathology, bone mineral density, and muscle strength were assessed. Immunohistochemistry and TUNEL staining were performed to evaluate markers for cartilage degeneration and chondrocyte apoptosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>At 14\u2009weeks of age, HFD-induced obesity increased liver and adipose tissue inflammation in SAMP8 without further exacerbating diabetes. Histological scoring revealed aggravated cartilage, menisci deterioration, and synovitis, while no further loss of bone mineral density or muscle strength was observed. Increased chondrocyte apoptosis was detected in knee joints following HFD feeding.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Ten weeks of HFD feeding promotes spontaneous OA progression in 14-week-old SAMP8, potentially via liver damage that subsequently leads to chondrocyte apoptosis. This ageing-obese mouse model may prove valuable for further exploration of spontaneous OA pathophysiology.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/road069","type":"journal-article","created":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T12:31:07Z","timestamp":1690806667000},"page":"831-840","source":"Crossref","is-referenced-by-count":8,"title":["High-fat diet-induced obesity accelerates the progression of\u00a0spontaneous osteoarthritis in\u00a0senescence-accelerated mouse prone 8"],"prefix":"10.1093","volume":"34","author":[{"given":"Chenyang","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University , Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilimulati","family":"Yimiti","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, 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Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiminori","family":"Matsubara","sequence":"additional","affiliation":[{"name":"Department of Human Life Science Education, Graduate School of Education, Hiroshima University , Higashi-Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuo","family":"Adachi","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University , Hiroshima, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1602-5777","authenticated-orcid":false,"given":"Shigeru","family":"Miyaki","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University , Hiroshima, Japan"},{"name":"Medical Center for Translational and Clinical Research, Hiroshima University Hospital , Hiroshima, 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