{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T05:12:37Z","timestamp":1784265157464,"version":"3.55.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,7,31]],"date-time":"2023-07-31T00:00:00Z","timestamp":1690761600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To develop a clinical instrument to assess carpal tunnel syndrome (CTS) severity before electrodiagnostic testing.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Data from 1037 patients with CTS (39.1% male) were included. The mean (SD) age was 58.0 (10.8) years. The severity of CTS was based on electrodiagnostic findings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>We devised a composite index incorporating a pain numeric rating scale (NRS) rated from 0 (no pain at all) to 10 (the worst pain ever possible), thenar muscle weakness or atrophy (TW), cross-sectional area (CSA) of the median nerve (mm2), and nocturnal pain (NP). The index was calculated as [scale(NRS)+scale(CSA)+NP+TW]\/4, where NP and TW are binary features (0 or 1). The accuracy and area under the curve of the index were 0.85 and 0.71, respectively (Cohen\u2019s Kappa = 0.51, McNemar\u2019s test P = 0.249). The index increased pretest probabilities by 1.6, 1.8, and 3.3 times with positive likelihood ratios of 3.3, 2.5, and 13.5, and false-positive rates of 26.6, 17.6, and 4.8% for mild, moderate, and severe CTS, respectively. The index thresholds for mild, moderate, and severe CTS were &amp;lt;0.8, \u22650.8 to &amp;lt;1.1, and \u22651.1, respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Using a composite index, patients with CTS can be categorized for the severity of the syndrome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/road076","type":"journal-article","created":{"date-parts":[[2023,7,28]],"date-time":"2023-07-28T12:34:45Z","timestamp":1690547685000},"page":"851-857","source":"Crossref","is-referenced-by-count":7,"title":["Development and\u00a0validation of\u00a0a clinical model for\u00a0predicting the severity of\u00a0carpal tunnel syndrome"],"prefix":"10.1093","volume":"34","author":[{"given":"Behnaz","family":"Aalaie","sequence":"first","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Hamadan University of Medical Sciences and Health Services , Hamadan, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javad","family":"Sadeghi","sequence":"additional","affiliation":[{"name":"Pain Clinic Manager, Be\u2019sat Hospital, Faculty of Medicine, Aja University of Medical Sciences , Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"School of Mathematics, Statistics, and Computer Science, College of Science, University of Tehran , Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8177-0725","authenticated-orcid":false,"given":"Babak","family":"Mohammadi","sequence":"additional","affiliation":[{"name":"Independent Scholar , Tehran, Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,7,31]]},"reference":[{"key":"2024070612133248600_R1","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/S1474-4422(16)30231-9","article-title":"Carpal tunnel syndrome: clinical features, diagnosis, and\u00a0management","volume":"15","author":"Padua","year":"2016","journal-title":"Lancet Neurol"},{"key":"2024070612133248600_R2","doi-asserted-by":"crossref","DOI":"10.1001\/jama.2022.10522","article-title":"What is carpal tunnel syndrome?","volume":"328","author":"Walter","year":"2022","journal-title":"JAMA"},{"key":"2024070612133248600_R3","doi-asserted-by":"crossref","first-page":"1654","DOI":"10.1212\/WNL.53.8.1654","article-title":"Multiperspective assessment of\u00a0carpal tunnel syndrome: a multicenter study. 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