{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:42:19Z","timestamp":1740109339354,"version":"3.37.3"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T00:00:00Z","timestamp":1694649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We previously reported that heating of the neck or elbows alleviated Raynaud\u2019s phenomenon in patients with systemic sclerosis and upregulated capillary extension factor angiopoietin-1 (Angpt-1) in the fingertips. In this study, we investigated which cases responded better to the effect of heating of the neck or elbows.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The pre- to postheating change in the visual analogue scale (\u0394VAS) for Raynaud\u2019s phenomenon was examined for correlation with age, disease duration, autoantibodies, disease types, corticosteroid dose, capillaroscopic nailfold capillary damage, fingertip Angpt-1 concentrations at baseline, and increased rate of Angpt-1 concentration.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The \u0394VAS for elbow heating correlated positively with the baseline Angpt-1 concentration, whereas opposite correlation was observed for neck heating. The other items did not significantly correlate with the \u0394VAS; however, the \u0394VAS for elbow heating tended to be larger in patients with advanced capillary damage, whereas an opposite trend was observed for neck heating.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Elbow and neck heating alleviated Raynaud\u2019s phenomenon to a similar extent, but their mechanism was different. Heating of the elbows had a greater effect on patients with advanced capillary damage and lower fingertip Angpt-1 concentrations.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/road091","type":"journal-article","created":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T16:12:11Z","timestamp":1694707931000},"page":"750-755","source":"Crossref","is-referenced-by-count":1,"title":["Heating of\u00a0the neck or elbows alleviates Raynaud\u2019s phenomenon but has different effects on\u00a0different types of\u00a0patients with systemic sclerosis"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2523-2938","authenticated-orcid":false,"given":"Yoshihito","family":"Shima","sequence":"first","affiliation":[{"name":"Laboratory of Thermo-therapeutics for Vascular Dysfunction, Osaka University Graduate School of Medicine , Suita, Japan"},{"name":"Department of Respiratory Medicine and Clinical Immunology, Osaka University Graduate School of 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