{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,9]],"date-time":"2026-02-09T20:17:59Z","timestamp":1770668279247,"version":"3.49.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:00:00Z","timestamp":1697760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,7,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This study was conducted to investigate the mechanisms of anaphylaxis in patients with osteoarthritis of the knee and hip after diclofenac etalhyaluronate [product name: JOYCLU\u00ae (JCL)] intra-articular injection and to determine the utility of tests to investigate the mechanism involved.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this observational study in Japan, patients aged \u226520\u2009years with knee or hip osteoarthritis who received JCL intra-articular injection experienced anaphylactic symptoms considered related to JCL (\u2018experienced patients\u2019) or did not experience allergic symptoms considered related to JCL (\u2018non-experienced patients\u2019). Basophil activation tests (BATs), specific immunoglobulin E (IgE) antibody testing by enzyme-linked immunosorbent assays (ELISAs) or immunochromatographic kit, and genome-wide association studies (GWASs) were conducted using patient blood and saliva.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Thirteen experienced patients and 14 non-experienced patients were tested. Seven experienced patients tested positive by BAT using diclofenac etalhyaluronate-containing test substances. Diclofenac-specific IgE antibodies were detected in four of seven BAT-positive patients but not in the non-experienced patients. Specific IgE antibody testing by immunochromatographic kit and genome-wide association study showed no clear results.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>These findings suggest that anaphylaxis occurs after JCL administration via an IgE-mediated mechanism and that diclofenac etalhyaluronate may be involved in this mechanism. BAT and diclofenac -specific IgE enzyme-linked immunosorbent assay may be useful tests for investigating the mechanisms of anaphylactic reactions after JCL administration.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/road100","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T19:08:37Z","timestamp":1697828917000},"page":"820-830","source":"Crossref","is-referenced-by-count":8,"title":["Clinical investigation for\u00a0the mechanisms of\u00a0anaphylactic symptoms in\u00a0osteoarthritis patients after diclofenac etalhyaluronate administration"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7511-6388","authenticated-orcid":false,"given":"Yoshihiro","family":"Nishida","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine, Rare Cancer Center, Nagoya University Hospital , Nagoya, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akiko","family":"Yagami","sequence":"additional","affiliation":[{"name":"Department of Allergology, Fujita Health University Bantane Hospital , Nagoya, Aichi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Takada","sequence":"additional","affiliation":[{"name":"Research and Development Division, Seikagaku Corporation , Higashiyamato, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dai","family":"Muramatsu","sequence":"additional","affiliation":[{"name":"Research and Development Division, Seikagaku Corporation , Higashiyamato, Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Nobuoka","sequence":"additional","affiliation":[{"name":"Research and Development Division, Seikagaku Corporation , Tokyo, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimichi","family":"Okayama","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Allergology, Misato Kenwa Hospital , Misato, Saitama, Japan"},{"name":"Department of Medicine, Division of Respiratory Medicine and Allergology, Showa University , Tokyo, Japan"},{"name":"Department of Internal Medicine, Division of Respiratory Medicine, Nihon University School of Medicine , Tokyo, Japan"},{"name":"Advanced Medical Science Research Center, Gunma Paz University Graduate School of Health Sciences , Takasaki, Gunma, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,10,20]]},"reference":[{"key":"2024070612130262700_R1","doi-asserted-by":"crossref","DOI":"10.1186\/s12891-019-2586-0","article-title":"Effect of\u00a0diclofenac etalhyaluronate (SI-613) on\u00a0the production of\u00a0high molecular weight sodium 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