{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T01:13:23Z","timestamp":1790558003089,"version":"4.1.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,8,20]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>The present study aimed to investigate the effectiveness of treatment with romosozumab for 1\u2009year and association between bone turnover markers and changes in bone mineral density (BMD) in patients with postmenopausal osteoporosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Participants were 53 treatment-na\u00efve postmenopausal osteoporosis patients. Correlations of per cent changes (\u0394) in lumbar (L) and total hip (TH) BMD 12\u2009months after initiating romosozumab with baseline demographic factors and parameters of N-terminal propeptide of Type 1 collagen (P1NP) and tartrate-resistant acid phosphatase-5b at baseline and Months 1, 3, and 6 were assessed. Multiple regression analysis was performed on factors significantly correlated with \u0394L-BMD and \u0394TH-BMD at Month 12.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>\u0394L-BMD and \u0394TH-BMD at Month 12 were 17.5% and 8.1%, respectively. Multiple regression analysis revealed that a high P1NP value at Month 3 predicted large increases in L-BMD and TH-BMD at Month 12. High total amount of P1NP values from baseline to Month 6 was associated with large increases in L-BMD and TH-BMD at Month 12 and was most strongly correlated with the P1NP value at Month 3.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>A high P1NP value at Month 3 predicted large increases in both L-BMD and TH-BMD at Month 12 in postmenopausal osteoporosis patients treated with romosozumab.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roae008","type":"journal-article","created":{"date-parts":[[2024,1,26]],"date-time":"2024-01-26T20:33:15Z","timestamp":1706301195000},"page":"1047-1055","source":"Crossref","is-referenced-by-count":10,"title":["Association between P1NP value and increases in bone mineral density in patients with postmenopausal osteoporosis treated with romosozumab"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2465-1281","authenticated-orcid":false,"given":"Kyosuke","family":"Hattori","sequence":"first","affiliation":[{"name":"Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital , Toyota, Aichi,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhide","family":"Kanayama","sequence":"additional","affiliation":[{"name":"Orthopedic Surgery and Rheumatology, Toyota Kosei Hospital , Toyota, Aichi,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,2,1]]},"reference":[{"key":"2024101507122328800_R1","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1016\/S0140-6736(10)62349-5","article-title":"Osteoporosis: now and the future","volume":"9","author":"Rachner","year":"2011","journal-title":"Lancet"},{"key":"2024101507122328800_R2","article-title":"Postmenopausal osteoporosis","volume":"29","author":"Eastell","year":"2016","journal-title":"Nat Rev Dis Primers"},{"key":"2024101507122328800_R3","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1016\/j.ecl.2005.07.009","article-title":"Pathophysiology of age-related bone loss and osteoporosis","volume":"34","author":"Khosla","year":"2005","journal-title":"Endocrinol Metab Clin North Am"},{"key":"2024101507122328800_R4","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.berh.2006.04.004","article-title":"Osteoporotic fractures in older adults","volume":"20","author":"Colon-Emeric","year":"2006","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2024101507122328800_R5","doi-asserted-by":"crossref","first-page":"571","DOI":"10.2174\/1566524023362104","article-title":"Bisphosphonate mechanism of action","volume":"2","author":"Rodan","year":"2002","journal-title":"Curr Mol Med"},{"key":"2024101507122328800_R6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4158\/EP161435.GL","article-title":"American Association of Clinical Endocrinologists and American College of Endocrinology clinical practice guidelines for the diagnosis and treatment of postmenopausal osteoporosis 2016","volume":"22","author":"Camacho","year":"2016","journal-title":"Endocr Pract"},{"key":"2024101507122328800_R7","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/jbmr.1476","article-title":"Previous fractures at multiple sites increase the risk for subsequent fractures: the global longitudinal study of osteoporosis in women","volume":"27","author":"Gehlbach","year":"2012","journal-title":"J Bone Miner Res"},{"key":"2024101507122328800_R8","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1210\/jc.2013-3461","article-title":"The impact of nonhip nonvertebral fractures in elderly women and men","volume":"99","author":"Bliuc","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"2024101507122328800_R9","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1177\/230949901001800204","article-title":"Mortality after vertebral fractures in a Japanese population","volume":"18","author":"Ikeda","year":"2010","journal-title":"J Orthop Surg"},{"key":"2024101507122328800_R10","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/jbmr.3641","article-title":"Change in bone density and reduction in fracture risk: a meta-regression of published trials","volume":"34","author":"Bouxsein","year":"2019","journal-title":"J Bone Miner Res"},{"key":"2024101507122328800_R11","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1007\/s00198-020-05569-9","article-title":"Is a treat-to-target strategy in osteoporosis applicable in clinical practice? 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