{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:28:54Z","timestamp":1787009334534,"version":"build-2736575974"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T00:00:00Z","timestamp":1710374400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Specific human leukocyte antigen (HLA) haplotypes are associated with Beh\u00e7et\u2019s disease. Because the effects of HLA-A26 and its combination with HLA-B51 on organ involvement in Beh\u00e7et\u2019s disease have not been well demonstrated, we aimed to examine them.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This multicentre, cross-sectional, observational study enrolled patients with Beh\u00e7et\u2019s disease who visited Kyoto University Hospital between 2018 and 2021 or Kurashiki Central Hospital between 2006 and 2016 (n\u2009=\u2009200). Disease severity was evaluated using the Krause score.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Uveitis and gastrointestinal involvement were observed in 95\/196 and 57\/167 patients, respectively. The HLA alleles identified were HLA-B51 (n\u2009=\u200952\/106), HLA-A26 (n\u2009=\u200925\/88), and HLA-B51 and HLA-A26 (n\u2009=\u20096\/88). In patients harbouring HLA-B51, the presence of HLA-A26 was associated with higher frequencies of uveitis (P\u2009=\u2009.03) and coexistence of uveitis and gastrointestinal involvement (P\u2009=\u2009.002) and higher Krause scores (P\u2009=\u2009.02). Furthermore, the presence of HLA-A26 was associated with a higher frequency of uveitis in patients with gastrointestinal involvement (P\u2009=\u2009.001) and gastrointestinal involvement in patients with uveitis (P\u2009=\u2009.001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Since specific HLA haplotypes and their combinations are associated with organ involvement, both HLA-A and HLA-B haplotypes should be confirmed when screening for affected organs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/mr\/roae022","type":"journal-article","created":{"date-parts":[[2024,3,14]],"date-time":"2024-03-14T02:53:43Z","timestamp":1710384823000},"page":"1221-1225","source":"Crossref","is-referenced-by-count":10,"title":["Significant association of HLA-A26 with uveitis and gastrointestinal involvement in patients with Beh\u00e7et\u2019s disease in a multicentre study"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4211-034X","authenticated-orcid":false,"given":"Tomoya","family":"Nakajima","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University , Kyoto,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2521-246X","authenticated-orcid":false,"given":"Hideaki","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University , Kyoto,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryuta","family":"Inaba","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Rheumatology, Kurashiki Central Hospital , Kurashiki, Okayama,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rintaro","family":"Saito","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University , Kyoto,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keisuke","family":"Nishimura","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Rheumatology, Kurashiki Central Hospital , Kurashiki, Okayama,","place":["Japan"]},{"name":"Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine , Kobe,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Morinobu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology, Graduate School of Medicine, Kyoto University , 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