{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:47:49Z","timestamp":1792640869017,"version":"4.5.0"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T00:00:00Z","timestamp":1716854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,25]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>To clarify the clinical features of anti-Ro52 antibody (Ab)-positive polymyositis (PM)\/dermatomyositis (DM).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We retrospectively examined the clinical features and status of anti-Ro52 Abs in patients with PM\/DM admitted to the University of Tsukuba Hospital between January 2019 and February 2023. We compared the anti-Ro52 Ab-positive and anti-Ro52 Ab-negative groups.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 40 patients were selected and analysed. Twenty-three cases were PM, and 17 cases were DM (including six clinically amyopathic DM). Twenty-two cases were positive for anti-Ro52 Ab, 14 for anti-ARS Ab, and 6 for anti-MDA5 Ab. Interstitial lung disease was detected in 29 cases, nine of which were rapidly progressive. Glucocorticoid-resistant cardiomyopathy was detected in six cases. Of the 22 anti-Ro52 Ab-positive cases, only 3 were single-positive and the remaining 19 cases simultaneously had other autoantibodies. Comparing the anti-Ro52 Ab-positive and anti-Ro52 Ab-negative groups, the frequencies of anti-ARS Ab positivity (63.6% vs. 0%), interstitial lung disease (95.5% vs. 44.4%), glucocorticoid-resistant cardiomyopathy (27.3% vs. 0%), concomitant use of immunosuppressants (95.5% vs. 55.6%), and levels of C-reactive protein were significantly higher in the anti-Ro52 Ab-positive group (P\u2009&amp;lt;\u2009.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Anti-Ro52 Abs were frequently positive in PM\/DM, and may be useful as a severity marker.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roae052","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T19:10:47Z","timestamp":1716923447000},"page":"118-125","source":"Crossref","is-referenced-by-count":7,"title":["Clinical importance of anti-Ro52 antibody in polymyositis and dermatomyositis"],"prefix":"10.1093","volume":"35","author":[{"given":"Toshiki","family":"Sugita","sequence":"first","affiliation":[{"name":"Department of Rheumatology, Institute of Medicine, University of Tsukuba , Ibaraki,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9067-0961","authenticated-orcid":false,"given":"Hiroto","family":"Tsuboi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Institute of Medicine, University of Tsukuba , Ibaraki,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Sugita","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Institute of Medicine, University of Tsukuba , Ibaraki,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rai","family":"Akiyoshi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Institute of Medicine, University of Tsukuba , Ibaraki,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Kuroda","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Institute of Medicine, University of Tsukuba , Ibaraki,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akira","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Institute of Medicine, University of Tsukuba , Ibaraki,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumina","family":"Kawashima","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Institute of Medicine, University of Tsukuba , Ibaraki,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daiki","family":"Tabuchi","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Institute of Medicine, University of Tsukuba , Ibaraki,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumika","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Institute of Medicine, University of Tsukuba , Ibaraki,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Ohyama","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Institute of Medicine, University of Tsukuba , Ibaraki,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saori","family":"Abe","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Institute of Medicine, University of Tsukuba , Ibaraki,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayako","family":"Kitada","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Institute of Medicine, University of Tsukuba , Ibaraki,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromitsu","family":"Asashima","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Institute of Medicine, University of Tsukuba , Ibaraki,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruka","family":"Miki","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Institute of Medicine, University of Tsukuba , Ibaraki,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinya","family":"Hagiwara","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Institute of Medicine, University of Tsukuba , Ibaraki,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Institute of Medicine, University of Tsukuba , Ibaraki,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Matsumoto","sequence":"additional","affiliation":[{"name":"Department of Rheumatology, Institute of Medicine, University of Tsukuba , Ibaraki,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,5,28]]},"reference":[{"key":"2025020515415710900_R1","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1056\/NEJM197502132920706","article-title":"Polymyositis and dermatomyositis (first of two parts)","volume":"292","author":"Bohan","year":"1975","journal-title":"N Engl J Med"},{"key":"2025020515415710900_R2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1038\/nrrheum.2018.41","article-title":"Classification of myositis","volume":"14","author":"Lundberg","year":"2018","journal-title":"Nat Rev 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antibodies impact in connective tissue diseases clinical management","volume":"21","author":"Decker","year":"2022","journal-title":"Autoimmun Rev"},{"key":"2025020515415710900_R12","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1136\/annrheumdis-2019-215488","article-title":"First external validation of sensitivity and specificity of European League Against Rheumatism (EULAR)\/ American College of Rheumatology (ACR) classification criteria for idiopathic inflammatory myopathies with a Japanese cohort","volume":"79","author":"Jinnin","year":"2020","journal-title":"Ann Rheum Dis"},{"key":"2025020515415710900_R13","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.jaad.2005.10.041","article-title":"A systemic review of adult-onset clinically amyopathic dermatomyositis (dermatomyositis sin\u00e9 myositis): a missing link within the spectrum of the idiopathic inflammatory myopathies","volume":"54","author":"Gerami","year":"2006","journal-title":"J Am Acad 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Arthritis Rheum"},{"key":"2025020515415710900_R23","doi-asserted-by":"crossref","first-page":"3343","DOI":"10.1093\/rheumatology\/keaa786","article-title":"Prognostic values of anti-Ro52 antibodies in anti-MDA5-positive clinically amyopathic dermatomyositis associated with interstitial lung disease","volume":"60","author":"Xu","year":"2021","journal-title":"Rheumatology (Oxford)"},{"key":"2025020515415710900_R24","doi-asserted-by":"crossref","first-page":"4570","DOI":"10.1093\/rheumatology\/keac090","article-title":"Anti-Ro52 antibodies are associated with the prognosis of adult idiopathic inflammatory myopathy-associated interstitial lung disease","volume":"61","author":"Gui","year":"2022","journal-title":"Rheumatology"},{"key":"2025020515415710900_R25","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s12016-020-08822-5","article-title":"Interstitial lung disease in anti-MDA5 positive dermatomyositis","volume":"60","author":"Wu","year":"2021","journal-title":"Clin Rev 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