{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:42:16Z","timestamp":1740109336648,"version":"3.37.3"},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2024,8,21]],"date-time":"2024-08-21T00:00:00Z","timestamp":1724198400000},"content-version":"vor","delay-in-days":15,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,25]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This systematic scoping review assess the effect of cyclophosphamide (CY) administration during childhood on ovarian function in patients with juvenile-onset connective tissue diseases.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A MEDLINE database search was conducted using terms related to CY, juvenile-onset connective tissue diseases, and ovarian function. Studies were included if they met specific criteria.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>The search, conducted on 28 November 2023, yielded 3328 references. After a two-stage screening process, six observational studies on systemic lupus erythematosus patients were included. All studies had a high risk of confounding bias, as none adjusted for confounding variables. Two studies assessing clinical ovarian dysfunction found no clear difference between CY and non-CY groups. However, statistical differences were observed in hormonal profiles. Decreased ovarian reserve was more frequent in CY-exposed patients. Two studies showed significantly higher follicle-stimulating hormone (FSH) levels in the CY group, while one showed a trend towards higher FSH levels without statistical significance.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This review suggested that CY use in childhood may not conclusively have clinically significant effects on ovarian function. Further investigation needed on CY\u2019s effect on hormonal levels, fertility, and pregnancy outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roae060","type":"journal-article","created":{"date-parts":[[2024,8,22]],"date-time":"2024-08-22T02:11:44Z","timestamp":1724292704000},"page":"88-93","source":"Crossref","is-referenced-by-count":0,"title":["Effects of cyclophosphamide administration on ovarian dysfunction in pediatric patients with connective tissue diseases: A systematic scoping review"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1020-0818","authenticated-orcid":false,"given":"Ken-ei","family":"Sada","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology, Kochi Medical School , Nankoku,","place":["Japan"]},{"name":"Subcommittee on reproductive issues in rheumatology, Japan College of Rheumatology , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takako","family":"Miyamae","sequence":"additional","affiliation":[{"name":"Subcommittee on reproductive issues in rheumatology, Japan College of Rheumatology , Tokyo,","place":["Japan"]},{"name":"Department of Pediatric Rheumatology, Institute of Rheumatology, Tokyo Women\u2019s Medical University , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3411-5896","authenticated-orcid":false,"given":"Kayoko","family":"Kaneko","sequence":"additional","affiliation":[{"name":"Subcommittee on reproductive issues in rheumatology, Japan College of Rheumatology , Tokyo,","place":["Japan"]},{"name":"Division of Maternal Medicine, Center of Maternal-Fetal, Neonatal and Reproductive Medicine, National Center for Child Health and Development , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sakiko","family":"Isojima","sequence":"additional","affiliation":[{"name":"Subcommittee on reproductive issues in rheumatology, Japan College of Rheumatology , Tokyo,","place":["Japan"]},{"name":"Division of Rheumatology, Department of Medicine, Showa University School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kunihiro","family":"Ichinose","sequence":"additional","affiliation":[{"name":"Subcommittee on reproductive issues in rheumatology, Japan College of Rheumatology , Tokyo,","place":["Japan"]},{"name":"Department of Rheumatology, Shimane University Faculty of Medicine , Izumo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masakazu","family":"Matsushita","sequence":"additional","affiliation":[{"name":"Subcommittee on reproductive issues in rheumatology, Japan College of Rheumatology , Tokyo,","place":["Japan"]},{"name":"Department of Internal Medicine and Rheumatology, Juntendo University School of Medicine , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Oku","sequence":"additional","affiliation":[{"name":"Subcommittee on reproductive issues in rheumatology, Japan College of Rheumatology , Tokyo,","place":["Japan"]},{"name":"Department of Rheumatology and Infectious Diseases, Kitasato University School of Medicine , Sagamihara,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasunori","family":"Iwata","sequence":"additional","affiliation":[{"name":"Subcommittee on reproductive issues in rheumatology, Japan College of Rheumatology , Tokyo,","place":["Japan"]},{"name":"Department of Nephrology and Rheumatology, Kanazawa University , Kanazawa,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keishi","family":"Fujio","sequence":"additional","affiliation":[{"name":"Subcommittee on reproductive issues in rheumatology, Japan College of Rheumatology , Tokyo,","place":["Japan"]},{"name":"Department of Allergy and Rheumatology, Graduate School of Medicine, The University of Tokyo , Tokyo,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuko","family":"Murashima","sequence":"additional","affiliation":[{"name":"Subcommittee on reproductive issues in rheumatology, Japan College of Rheumatology , Tokyo,","place":["Japan"]},{"name":"Japan Drug Information Institute in Pregnancy, National Center for Child Health and Development , 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