{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,5]],"date-time":"2025-03-05T05:48:14Z","timestamp":1741153694433,"version":"3.38.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T00:00:00Z","timestamp":1722816000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,2,21]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We aimed to assess first-degree relatives (FDRs) of Beh\u00e7et\u2019s disease (BD) patients for the presence of clinical symptoms and signs of BD and evaluate common femoral vein (CFV) wall thickness measurement for the diagnosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Patients with BD (n\u2009=\u2009129) and FDRs (n\u2009=\u2009230) of these patients were included. FDRs were questioned in terms of BD symptoms by phone. Pathergy test and CFV wall thickness measurement were performed among 111 FDRs who accepted the clinical assessment. Clinical assessment groups were classified according to the criteria sets for BD. FDRs who did not meet the criteria sets and had at least one clinical finding in addition to oral aphthae (OA) were categorized as the \u2018suspected BD\u2019.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>: We observed increased frequency of isolated BD manifestations in FDRs. Ten FDRs were diagnosed with BD during clinical evaluation. A significantly increased CFV wall thickness was observed in FDRs of BD patients fulfilling diagnostic BD criteria (P\u2009&amp;lt;\u2009.001 for both sides) and also in those with suspected BD group (P\u2009&amp;lt;\u2009.05 for both sides). The presence of OA, genital ulcer, folliculitis, or erythema nodosum was associated with increased CFV wall thickness (P\u2009&amp;lt;\u2009.05).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our results suggest that the CFV wall thickness measurement can be used in the diagnosis of familial BD.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/mr\/roae061","type":"journal-article","created":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T13:35:41Z","timestamp":1722778541000},"page":"371-377","source":"Crossref","is-referenced-by-count":0,"title":["Screening for familial disease presence in first-degree relatives of Beh\u00e7et\u2019s disease patients: Is measurement of common femoral vein wall thickness valuable for the diagnosis?"],"prefix":"10.1093","volume":"35","author":[{"given":"Ay\u015fe Elif","family":"Boncukcuo\u011flu","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Marmara University School of Medicine , Istanbul,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erhan","family":"Topal","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Marmara University School of Medicine , Istanbul,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rabia","family":"Ergelen","sequence":"additional","affiliation":[{"name":"Department of Radiology, Marmara University School of Medicine , Istanbul,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilara","family":"Ka\u015f","sequence":"additional","affiliation":[{"name":"Marmara University School of Medicine , Istanbul,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elifnur","family":"Alkan","sequence":"additional","affiliation":[{"name":"Marmara University School of Medicine , Istanbul,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gamzenur","family":"Kaya","sequence":"additional","affiliation":[{"name":"Marmara University School of Medicine , Istanbul,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u015eevket","family":"Girgin","sequence":"additional","affiliation":[{"name":"Department of Public Health, Marmara University School of Medicine , Istanbul,","place":["Turkey"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T\u00fclin","family":"Ergun","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Marmara University School of Medicine , 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